4.3 Article

Alemtuzumab treatment exemplifies discordant immune effects of blood and cerebrospinal fluid in multiple sclerosis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Clinical Neurology

Autoimmunity and long-term safety and efficacy of alemtuzumab for multiple sclerosis: Benefit/risk following review of trial and post-marketing data

Alasdair J. Coles et al.

Summary: In individuals with relapsing-remitting multiple sclerosis (MS) after alemtuzumab, preexisting or treatment-emergent autoimmunity does not increase the risk of subsequent autoimmune disease. Additionally, thyroid autoimmunity after alemtuzumab treatment does not lead to an increased risk of non-thyroid autoimmune adverse events. Post-marketing safety data contribute to a comprehensive understanding of the benefits and risks of alemtuzumab in the field of MS.

MULTIPLE SCLEROSIS JOURNAL (2022)

Article Cell Biology

A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis

Patrick Ostkamp et al.

Summary: This study reveals the presence of CNS-infiltrating lymphocytes in peripheral central nervous system (CNS) cells as a hallmark of relapsing-remitting multiple sclerosis. Through a comprehensive analysis of human cerebrospinal fluid (CSF) and CNS parenchyma single-cell RNA sequencing samples, the researchers identified tissue-resident memory T cells (T-RM) and CNS-resident myeloid cells in CSF. These findings have important implications for the detection and treatment of multiple sclerosis.

SCIENCE TRANSLATIONAL MEDICINE (2022)

Article Clinical Neurology

Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity

Tobias Ruck et al.

Summary: Ruck et al. investigate the immunological basis of secondary autoimmunity after alemtuzumab and find that the dynamics of clonal T- and B-cell expansions are associated with the development of autoimmunity. They suggest that T-cell receptor repertoire analyses at baseline may help predict secondary autoimmunity and guide clinical decision-making.
Article Biotechnology & Applied Microbiology

Cell type prioritization in single-cell data

Michael A. Skinnider et al.

Summary: The Augur method can effectively identify the cell types most responsive to biological perturbations in single-cell data, helping to explore the relationship between gene expression changes and biological functions.

NATURE BIOTECHNOLOGY (2021)

Review Clinical Neurology

Contributions of T cells in multiple sclerosis: what do we currently know?

Borros Arneth

Summary: Multiple sclerosis (MS) is a complex autoimmune disorder characterized by neurologic dysfunction that worsens as the disease progresses. This study aimed to examine the role of T cells in MS pathogenesis, revealing significant link between MS and T cell activity. Targeting T cells is a potential strategy for the development of new therapies to manage MS, indicating the influence of effector T cells and regulatory T cells on MS development and progression.

JOURNAL OF NEUROLOGY (2021)

Article Immunology

Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid

Michael Heming et al.

Summary: Patients with COVID-19 can develop neurological sequelae referred to as Neuro-COVID, characterized by symptoms like headache and neuroinflammation. Research on the immune cell profiles in the cerebrospinal fluid of Neuro-COVID patients suggests compromised antiviral responses and different immune cell populations in these individuals.

IMMUNITY (2021)

Article Pharmacology & Pharmacy

Targeting CD52 does not affect murine neuron and microglia function

Erik Ellwardt et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

David Schafflick et al.

NATURE COMMUNICATIONS (2020)

Review Immunology

Meningeal Immunity and Its Function in Maintenance of the Central Nervous System in Health and Disease

Kalil Alves de Lima et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 38 (2020)

Review Immunology

B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers

Jamie van Langelaar et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

Marta Joana Costa Jordao et al.

SCIENCE (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Biochemical Research Methods

Fast, sensitive and accurate integration of single-cell data with Harmony

Ilya Korsunsky et al.

NATURE METHODS (2019)

Review Medicine, General & Internal

Multiple sclerosis

Alan J. Thompson et al.

LANCET (2018)

Article Biochemistry & Molecular Biology

Memory B Cells Activate Brain-Homing, Autoreactive CD4+ T Cells in Multiple Sclerosis

Ivan Jelcic et al.

Review Biochemistry & Molecular Biology

Alemtuzumab in Multiple Sclerosis: Mechanism of Action and Beyond

Tobias Ruck et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)

Article Clinical Neurology

Alemtuzumab treatment of multiple sclerosis: long-term safety and efficacy

Orla Tuohy et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2015)

Review Immunology

The anatomical and cellular basis of immune surveillance in the central nervous system

Richard M. Ransohoff et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Clinical Neurology

Expression of CCR7 in multiple sclerosis:: Implications for CNS immunity

P Kivisäkk et al.

ANNALS OF NEUROLOGY (2004)