Starvation-induced sleep suppression requires the Drosophila brain nutrient sensor

Article Multidisciplinary Sciences

A neural circuit linking learning and sleep in Drosophila long-term memory

Zhengchang Lei et al.

Summary: Learning enhances sleep, and a neural circuit in Drosophila mediates the learning-induced sleep, ensuring that only long or intense learning experiences are consolidated into long-term memory.

NATURE COMMUNICATIONS (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain

Annika F. Barber et al.

Summary: Regulation of circadian behavior and physiology by the Drosophila brain clock requires communication from central clock neurons to downstream output regions. Morning and evening clock neurons have time-of-day-dependent connectivity to the pars intercerebralis, which is regulated by specific peptides and fast neurotransmitters. This study provides insights into mechanisms by which clock neurons signal to nonclock cells to drive rhythms of behavior.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling

Xi Jin et al.

Summary: The study found that prolonged increasing of ambient temperature induces reversible sleep reduction and impaired sleep consolidation in fruit flies by activating the internal thermosensory anterior cells. The AC-DN1p-PI neural circuit is responsible for integrating thermosensory inputs into the sleep neural circuit.

CURRENT BIOLOGY (2021)

添加到收藏夹

Article Neurosciences

Periphery signals generated by Piezo-mediated stomach stretch and Neuromedin-mediated glucose load regulate the Drosophila brain nutrient sensor

Yangkyun Oh et al.

Summary: Two satiety signals inhibiting DH44 nutrient sensor activity have been identified: Piezo-mediated stomach/crop stretch and Neuromedin/Hugin neurosecretory neurons activated by an increase in internal glucose levels. These signals work together to regulate DH44 sensor activity in fed flies.

NEURON (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Chronic social isolation signals starvation and reduces sleep in Drosophila

Wanhe Li et al.

Summary: Social isolation can lead to chronic sleep loss and increased food consumption in Drosophila, mimicking the hyperphagia seen in lonely humans. Chronic social isolation alters the expression of metabolic genes and induces a brain state that signals starvation, promoting sleep loss and overconsumption of food. Neural activities in specific neurons play a crucial role in the link between chronic social isolation, metabolism, and sleep.

NATURE (2021)

添加到收藏夹

Article Biology

Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

Sebastian Hueckesfeld et al.

Summary: In this study, using electron microscopy reconstruction, researchers revealed the sensory pathways and synaptic inputs provided by interneurons to neurosecretory cells in the central nervous system of Drosophila larvae. The findings identified a novel carbon dioxide-responsive network targeting specific neurosecretory cells expressing neuropeptides such as Crz and Dh44. The analysis uncovered a neuronal network architecture for combinatorial action based on sensory and interneuronal pathways converging onto distinct combinations of neuroendocrine outputs.

ELIFE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology