相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。
Article
Genetics & Heredity
Hoyeon Lee et al.
Summary: This study demonstrates that circadian clocks regulate light-induced arousal in Drosophila sleep behavior. The arousal effects are mediated by glutamate transmission from octopaminergic neurons and are masked by light. Different groups of circadian pacemaker neurons are involved in light-induced arousal and free-running behavioral rhythms. These findings provide convincing evidence for circadian control of sleep.
JOURNAL OF NEUROGENETICS
(2023)
Review
Genetics & Heredity
Sunggyu Yoon et al.
Summary: The brain communicates with other organs to regulate physiological functions such as nutrient sensing, gastrointestinal activity, development, and immunity. Studying Drosophila can provide insights into homologous pathways in human development and disease models.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Mari Kim et al.
Summary: Exposure to dim light at night affects the circadian rhythm and metabolism in Drosophila, leading to decreased levels of branched-chain amino acids and increased expression of enzymes involved in their metabolism. Flies with mutations in the Bcat gene are less vulnerable to starvation stress, and reducing Bcat expression suppresses this vulnerability. Feeding BCAAs to wild-type flies exposed to dim light at night reverses the metabolic vulnerability.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Sun Joo Cha et al.
Summary: This study identifies GSTO as a critical modulator of the development of neurodegenerative diseases by regulating the localization and aggregation of Caz protein in the nervous system of Drosophila.
JOURNAL OF NEUROGENETICS
(2023)
Review
Genetics & Heredity
Greg S. B. Suh et al.
Summary: Neurogenetic research using the Drosophila model has significantly advanced in South Korea, leading to important discoveries and implications. The introduction of the Drosophila system in the 1990s elevated neural developmental studies, and the establishment of related resources supported pioneer research in modeling human diseases and understanding genes and neural circuits regulating animal behavior and physiology.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Shinrye Lee et al.
Summary: This study reveals that Tau overexpression leads to the accumulation of polyubiquitinated proteins, activates the autophagy-lysosome pathway, and causes cell toxicity. Inhibition of PTK2 can attenuate Tau-induced cell death and suppress Tau-induced phosphorylation of PTK2 and p62. Additionally, PTK2 inhibition mitigates motor defects and lifespan reduction in a Drosophila model of tauopathy.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Jineun Kim et al.
Summary: Animals can detect the nutritional content of sugar independently of taste. When given a choice, animals prefer nutritive sugar over nonnutritive sugar during food deprivation. Using a 3D pose estimation system called AVATAR, researchers found that mice exhibit different behavioral responses toward nutritive and nonnutritive sugar even before licking a sugar solution. This suggests that the nutritional value of sugar promotes its consumption and elicits distinct feeding behavior in deprived mice.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Geonil Kim et al.
Summary: In this study, the researchers observed the body kinematics of flying Drosophila using a magnetically tethered flight assay and characterized the kinematics of multiple body parts in flying animals using deep learning-based video analyses. They found that both spontaneous flight saccades and bar-fixating saccades involved movements of multiple body parts and had comparable dynamics. This study highlights the importance of sensitive behavioral assays and analysis tools for characterizing complex visual behaviors.
JOURNAL OF NEUROGENETICS
(2023)
Article
Genetics & Heredity
Seung Yeon Lim et al.
Summary: This study provides a valuable resource of GAL4 lines and split-GAL4 lines to target and manipulate different cell types and regions in the Drosophila gut, facilitating a more precise investigation of gut cells that regulate important biological processes.
JOURNAL OF NEUROGENETICS
(2021)
Article
Genetics & Heredity
Sooin Jang et al.
Summary: Research on Drosophila enteroendocrine cells revealed a diverse composition of regulatory peptides during metamorphosis, indicating possible differentiation into distinct subtypes that express different combinations of peptides. The differential regulation of peptide expression spatially and temporally by enteroendocrine cells in the midgut suggests functional variety depending on specific needs. Loss of Notch activity in different regions of the midgut results in distinct classes of enteroendocrine cells, further supporting the idea of dynamic differentiation and functional diversity among these cells.
JOURNAL OF NEUROGENETICS
(2021)
