4.5 Article

Metabolic delineation of IDH1 wild-type glioblastoma surgical anatomy: how to plan the tumor extent of resection

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

IDH-wild-type glioblastoma cell density and infiltration distribution influence on supramarginal resection and its impact on overall survival: a mathematical model

Shashwat Tripathi et al.

Summary: This study aimed to investigate the impact of mathematical models based on cell distribution and infiltration profiles on overall survival (OS) of IDH-wild-type GBM patients. The results showed that resecting the tumor can improve OS in patients with moderately and highly diffuse IDH-wild-type GBMs.

JOURNAL OF NEUROSURGERY (2022)

Article Clinical Neurology

Influence of supramarginal resection on survival outcomes after gross-total resection of IDH-wild-type glioblastoma

Tito Vivas-Buitrago et al.

Summary: The study found that performing at least 20% SMR of the CE tumor is associated with improved OS, while over 60% SMR does not significantly influence OS.

JOURNAL OF NEUROSURGERY (2022)

Article Clinical Neurology

FLAIRectomy in Supramarginal Resection of Glioblastoma Correlates With Clinical Outcome and Survival Analysis: A Prospective, Single Institution, Case Series

Francesco Certo et al.

Summary: The study demonstrated that EOTR based on FLAIR and 5-ALA fluorescence is feasible and provides better survival predictions. FLAIR volumetric evaluation showed larger tumor volume and stronger correlation with survival outcomes compared to T1-weighted MR images.

OPERATIVE NEUROSURGERY (2021)

Article Clinical Neurology

Recurrent high-grade glioma surgery: a multimodal intraoperative protocol to safely increase extent of tumor resection and analysis of its impact on patient outcome

Giuseppe Maria Vincenzo Barbagallo et al.

Summary: This study presents the integration of multiple technologies including neuronavigation, 5-ALA fluorescence, iUS, iCT, C-11-MET-PET, and IOM during microsurgical resection of recurrent glioma. The authors believe that this multimodal protocol is useful in increasing safety, effectiveness, and extent of tumor resection in patients with recurrent HGG and brain alterations.

NEUROSURGICAL FOCUS (2021)

Article Oncology

High Grade Glioma Treatment in Elderly People: Is It Different Than in Younger Patients? Analysis of Surgical Management Guided by an Intraoperative Multimodal Approach and Its Impact on Clinical Outcome

Giuseppe Maria Vincenzo Barbagallo et al.

Summary: This study analyzed the differences in outcomes between elderly and younger patients undergoing HGG maximal safe resection guided by an intraoperative multimodal imaging protocol and neuromonitoring. The results showed no statistically significant differences in post-operative EOTR, KPS, OS, and PFS between the two age groups, indicating that age may not impact the benefits of aggressive treatment for HGG.

FRONTIERS IN ONCOLOGY (2021)

Review Neurosciences

Peritumoral Microenvironment in High-Grade Gliomas: From FLAIRectomy to Microglia-Glioma Cross-Talk

Roberto Altieri et al.

Summary: The composition and molecular signatures of the glioma core and infiltrative margins differ, with the tumor edge enriched in microglia. Microglia in HGGs play a dual role, with activation in M1 phenotype exhibiting a scavenger-tumoricidal role, while activation in M2 phenotype favoring tumor growth and infiltration. Modulation of microglia-glioma cross-talk may lead to more effective therapies.

BRAIN SCIENCES (2021)

Article Multidisciplinary Sciences

Oncological and functional outcomes of supratotal resection of IDH1 wild-type glioblastoma based on 11C-methionine PET: a retrospective, single-center study

Seiichiro Hirono et al.

Summary: In this study comparing SupTR and GTR in GBM patients, it was found that SupTR led to improved local control and survival without postoperative neurocognitive decline. The different patterns of disease progression and distant recurrences observed in the SupTR group highlight the benefits of aggressive resection of both CE tumors and areas with Met uptake, especially under awake craniotomy with functional mapping.

SCIENTIFIC REPORTS (2021)

Article Oncology

Radiological evaluation of ex novo high grade glioma: velocity of diametric expansion and acceleration time study

Roberto Altieri et al.

Summary: This study investigated the velocity of diametric expansion (VDE) and acceleration growth in patients with high grade gliomas (HGG) using MRI scans. Findings showed a strong aggressiveness of HGG, highlighting the importance of timely surgery following repeated MRI scans.

RADIOLOGY AND ONCOLOGY (2021)

Article Clinical Neurology

Natural history of de novo high grade glioma: first description of growth parabola

Roberto Altieri et al.

JOURNAL OF NEUROSURGICAL SCIENCES (2020)

Article Radiology, Nuclear Medicine & Medical Imaging

Performance of 18F-FDG, 11C-Methionine, and 18F-FET PET for Glioma Grading A Meta-analysis

Aristeidis H. Katsanos et al.

CLINICAL NUCLEAR MEDICINE (2019)

Article Clinical Neurology

Glioma surgery: From preservation of motor skills to conservation of cognitive functions

Roberto Altieri et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2019)

Article Clinical Neurology

Tumor location and patient age predict biological signatures of high-grade gliomas

Roberto Altieri et al.

NEUROSURGICAL REVIEW (2018)

Article Clinical Neurology

Extending the resection beyond the contrast-enhancement for glioblastoma: feasibility, efficacy, and outcomes

David Mampre et al.

BRITISH JOURNAL OF NEUROSURGERY (2018)

Review Clinical Neurology

Role of Surgical Resection in Low- and High-Grade Gliomas

Shawn L. Hervey-Jumper et al.

CURRENT TREATMENT OPTIONS IN NEUROLOGY (2014)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)