4.7 Article

The Cytotoxic Cardiac Glycoside (-)-Cryptanoside A from the Stems of Cryptolepis dubia and Its Molecular Targets

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

Na,K-ATPase: A murzyme facilitating thermodynamic equilibriums at the membrane-interface

Kelath Murali Manoj et al.

Summary: The redox metabolic paradigm emphasizes the importance of diffusible reactive species (DRS), particularly oxygen-centric radicals, in physiology. This article focuses on the membrane protein Na,K-ATPase (NKA) and its role in neuro-cardio-musculo electrophysiology. Through analyzing diffusion, NKA's structural features, ion transport mechanisms, and inhibitory effects of various substances, a minimalist murburn model is proposed to explain the physiological inhibitory effects of different substances on cells.

JOURNAL OF CELLULAR PHYSIOLOGY (2023)

Article Plant Sciences

Discovery of Anticancer Agents of Diverse Natural Origin

Leslie N. Aldrich et al.

Summary: Research progress in the discovery of potential anticancer agents from various organisms has been summarized. Lead compounds with structural diversity have been obtained, and potential antitumor activities have been demonstrated. Further investigations are warranted for promising lead compounds.

JOURNAL OF NATURAL PRODUCTS (2022)

Article Oncology

Specific targeting of glioblastoma with an oncolytic virus expressing a cetuximab-CCL5 fusion protein via innate and adaptive immunity

Lei Tian et al.

Summary: The study developed an oncolytic virus, OV-Cmab-CCL5, that targets EGFR(+) glioblastoma cells and releases CCL5 into the tumor microenvironment, promoting anti-tumor immune responses and prolonging survival in preclinical GBM models.

NATURE CANCER (2022)

Review Pharmacology & Pharmacy

Targeting Akt/PKB in pediatric tumors: A review from preclinical to clinical trials

Bruno Toson et al.

Summary: This article reviews the application of Akt inhibitors in pediatric cancers. The study demonstrates the impact of Akt inhibition on tumorigenesis and suggests targeting the PI3K/Akt/mTOR signaling pathway as an effective approach for treating pediatric tumors.

PHARMACOLOGICAL RESEARCH (2022)

Review Cell Biology

Akt: a key transducer in cancer

Pei-Jane Tsai et al.

Summary: Growth factor signaling is crucial in various biological processes, and its dysregulation is associated with various human diseases. Akt kinase acts as a central regulator, transmitting signals from the extracellular environment to different cellular compartments to execute these processes. Understanding the molecular mechanisms of Akt signaling networks provides insights for developing selective inhibitors targeting Akt activation in human diseases, including cancer.

JOURNAL OF BIOMEDICAL SCIENCE (2022)

Article Neurosciences

Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury

Heena Khan et al.

Summary: The PI3K signaling pathway plays a neuroprotective role in cerebral ischemic reperfusion injury by inhibiting the apoptotic pathway. Modulation of the phosphatidylinositol 3-kinase pathway with activators and inhibitors may provide promising results in treating cerebral ischemic injury.

BRAIN RESEARCH (2021)

Article Multidisciplinary Sciences

An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma

Bo Xu et al.

Summary: Oncolytic herpes simplex virus-1 can lyse tumor cells and activate the immune system; oncolytic viruses expressing anti-CD47 antibodies can improve the survival of glioblastoma patients.

NATURE COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Cardiac Glycosides as Immune System Modulators

Jan Skubnik et al.

Summary: Cardiac glycosides have shown potential not just in treating cardiac diseases, but also as anticancer agents. They induce multiple signaling pathways to inhibit tumor growth, interact with immune cell death mechanisms, and modulate immune response genes, suggesting a wide range of potential applications in treating autoimmune and inflammatory diseases.

BIOMOLECULES (2021)

Article Biochemistry & Molecular Biology

Interaction of (+)-Strebloside and Its Derivatives with Na+/K+-ATPase and Other Targets

Yulin Ren et al.

Summary: The study found that (+)-strebloside may be more promising than digoxin in developing potential anticancer agents, as it can target multiple molecular targets and mediate the antitumor activity of cardiac glycosides.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Structural Insights into the Interactions of Digoxin and Na+/K+-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation

Yulin Ren et al.

Summary: Digoxin, a cardiac glycoside, has been found to exhibit antitumor potential and its cytotoxicity is influenced by specific structural features and interactions with Na+/K+-ATPase. Docking studies also suggest that the docking scores of digoxin and its derivatives correlate with their cytotoxicity, indicating their potential use in predicting the cytotoxicity of other cardiac glycosides. Additionally, digoxin was found to directly target FIH-1, Na+/K+-ATPase, and NF-kappa B for its antitumor effects.

MOLECULES (2021)

Review Oncology

Clinical significance of P-class pumps in cancer

Sophia C. Themistocleous et al.

Summary: P-class pumps play crucial roles in cancer cells by affecting pump function, inhibiting cell proliferation, inducing apoptosis, modifying metabolic pathways, and increasing sensitivity to chemotherapy, highlighting their potential as anticancer therapeutic targets.

ONCOLOGY LETTERS (2021)

Article Biochemistry & Molecular Biology

Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper

Yulin Ren et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

Article Plant Sciences

Na+/K+-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives

Yulin Ren et al.

JOURNAL OF NATURAL PRODUCTS (2020)

Review Biochemistry & Molecular Biology

Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions

Dhanasekhar Reddy et al.

MOLECULES (2020)

Review Cell Biology

NFKB1 and Cancer: Friend or Foe?

Julia Concetti et al.

Review Immunology

NF-κB, inflammation, immunity and cancer: coming of age

Koji Taniguchi et al.

NATURE REVIEWS IMMUNOLOGY (2018)

Article Plant Sciences

Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity

Yulin Ren et al.

JOURNAL OF NATURAL PRODUCTS (2017)

Review Medicine, Research & Experimental

Plant-derived cardiac glycosides: Role in heart ailments and cancer management

Seema Patel

BIOMEDICINE & PHARMACOTHERAPY (2016)

Review Cell Biology

ROS and ROS-Mediated Cellular Signaling

Jixiang Zhang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

Article Biotechnology & Applied Microbiology

Analgesic, Anti-Inflammatory, and Chondroprotective Activities of Cryptolepis buchanani Extract: In Vitro and In Vivo Studies

Nutthiya Hanprasertpong et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Review Biochemistry & Molecular Biology

Emerging avenues linking inflammation and cancer

Joydeb Kumar Kundu et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Article Biochemistry & Molecular Biology

Ligand docking and binding site analysis with PyMOL and Autodock/Vina

Daniel Seeliger et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2010)

Article Biochemistry & Molecular Biology

Epik:: a software program for pK a prediction and protonation state generation for drug-like molecules

John C. Shelley et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)

Article Oncology

The transcription factor nuclear factor-kappa B and cancer

R. O. Escarcega et al.

CLINICAL ONCOLOGY (2007)

Article Chemistry, Medicinal

Immunopotentiating properties of Cryptolepis buchanani root extract

A Kaul et al.

PHYTOTHERAPY RESEARCH (2003)

Article Biochemistry & Molecular Biology

Improved protein-ligand docking using GOLD

ML Verdonk et al.

PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)

Article Biochemistry & Molecular Biology

Inhibition of Na,K-ATPase activates P13 kinase and inhibits apoptosis in LLC-PK1 cells

XM Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)