Anti-Aphid Polyketides from Streptomyces sp. SA61

Myzus persicae (Sulzer) is a crop pest causing serious economic losses around the world. For many decades, the management of M. persicae has relied heavily on chemical pesticides, resulting in the development of resistance, and new compounds with activity against M. persicae are needed. Five novel polyketides, strekingmycins A-E (1-5), were isolated from Streptomyces sp. SA61. Their structures were determined based on MS, NMR, and X-ray diffraction data. Strekingmycins were active against M. persicae between 4.4 and 9.4 mu g/mL.

Automated summary

Myzus persicae (Sulzer) is a crop pest causing economic losses globally. Chemical pesticides have been heavily relied upon to manage this pest, resulting in resistance. New compounds effective against M. persicae are needed. Five novel polyketides, strekingmycins A-E (1-5), were isolated from Streptomyces sp. SA61. Their structures were determined using MS, NMR, and X-ray diffraction. Strekingmycins showed activity against M. persicae at concentrations between 4.4 and 9.4 μg/mL.