Green synthesized magnetic nanoparticles for selective inhibition of osteosarcoma cancer

Here, selective anti-cancer activity of poly-l-lysine-functionalized iron oxide nanoparticles (PLL@IONPs) has been shown against osteosarcoma cancer. The mentioned nanoparticles were synthesized from Spinacia oleracia (spinach) leaf extract. In-vitro, osteosarcoma cells incubated with the synthesized nanoparticles showed the selective cytotoxicity. Particles exposed to the normal fibroblast cells displayed significantly less cytotoxic effects. Interestingly, the reactive oxygen species (ROS) generation was inhibited by the synthesized material with their intrinsic free radical scavenging activity. In-vivo, PLL@IONPs significantly inhibited the site-specific angiogenesis in chick embryo. This could lead to the site-specific therapeutic efficiency. In addition, suspected carcinogenic dyes were degraded by the particles and provided a cancer-preventive aspect. The results suggest that PLL@IONPs could be significantly applied as a therapeutic against osteosarcoma cancer as well as carcinogen degradation measure.

Automated summary

This study demonstrates the selective anti-cancer activity of poly-l-lysine-functionalized iron oxide nanoparticles (PLL@IONPs) against osteosarcoma cancer. The nanoparticles were synthesized from spinach leaf extract. In vitro experiments showed selective cytotoxicity of the synthesized nanoparticles against osteosarcoma cells, while normal fibroblast cells were less affected. The nanoparticles also exhibited free radical scavenging activity and inhibited reactive oxygen species (ROS) generation. In vivo, PLL@IONPs inhibited site-specific angiogenesis and could potentially be used as a therapeutic for osteosarcoma cancer as well as a measure for carcinogen degradation.