4.6 Article

Urease inhibitory activity on 1,2,3-triazoles-linked indomethacin derivatives; in vitro and in silico studies

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Dihydroquinazolin-4(1H)-one derivatives as novel and potential leads for diabetic management

Oluwatoyin Babatunde et al.

Summary: A series of dihydroquinazolin-4(1H)-one derivatives were synthesized in this study and evaluated for their inhibitory activities against alpha-amylase and alpha-glucosidase enzymes. The compounds showed significant to moderate inhibition potential, with different substituents affecting their inhibitory potency. Kinetic studies revealed competitive inhibition for alpha-amylase and non-competitive inhibition for alpha-glucosidase, while in silico analysis identified important binding interactions with the active sites of the enzymes.

MOLECULAR DIVERSITY (2022)

Article Biochemistry & Molecular Biology

Evaluation of synthetic 2-aryl quinoxaline derivatives as α-amylase, α-glucosidase, acetylcholinesterase, and butyrylcholinesterase inhibitors

Shehryar Hameed et al.

Summary: A variety of 2-aryl quinoxaline derivatives were successfully synthesized in good yields by reacting 1,2-phenylenediamine with different substituted phenacyl bromides in the presence of pyridine catalyst. These synthetic derivatives showed enhanced inhibitory potential against alpha-amylase, alpha-glucosidase, acetylcholinesterase, and butyrylcholinesterase at nanomolar concentrations, with compound 14 demonstrating superior activity compared to standard inhibitors. Selected potent compounds were further analyzed through molecular docking studies to understand their binding energies and interactions with the target enzymes.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

Article Biochemistry & Molecular Biology

4-Oxycoumarinyl linked acetohydrazide Schiff bases as potent urease inhibitors

Fouzia Naz et al.

BIOORGANIC CHEMISTRY (2020)

Review Chemistry, Inorganic & Nuclear

Role of Nickel in Microbial Pathogenesis

Robert J. Maier et al.

INORGANICS (2019)

Article Biochemistry & Molecular Biology

New carbazole linked 1,2,3-triazoles as highly potent non-sugar α-glucosidase inhibitors

Shazia Iqbal et al.

BIOORGANIC CHEMISTRY (2017)

Article Gastroenterology & Hepatology

Pathobiology of Helicobacter pylori-Induced Gastric Cancer

Manuel Amieva et al.

GASTROENTEROLOGY (2016)

Article Clinical Neurology

The Pharmacology of Indomethacin

Sylvia Lucas

HEADACHE (2016)

Article Chemistry, Medicinal

Synthesis and In vitro Evaluation of Dibenzoazepine Triazole Derivatives: A Novel Class of Antileishmanial Agents

Maria Aqeel Khan et al.

Letters in Drug Design & Discovery (2015)

Review Medicine, General & Internal

Role of Indomethacin in Acute Pain and Inflammation Management:A Review of the Literature

Srinivas Nalamachu et al.

POSTGRADUATE MEDICINE (2014)

Article Microbiology

The Emerging Role of Urease as a General Microbial Virulence Factor

Julian C. Rutherford

PLOS PATHOGENS (2014)

Review Biochemistry & Molecular Biology

Bacterial Urease and its Role in Long-Lasting Human Diseases

Iwona Konieczna et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2012)

Review Biochemistry & Molecular Biology

Ureases I. Functional, catalytic and kinetic properties: A review

Barbara Krajewska

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC (2009)

Review Microbiology

Pathogenesis of Helicobacter pylori infection

Johannes G. Kusters et al.

CLINICAL MICROBIOLOGY REVIEWS (2006)