4.7 Article

Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

An environmentally benign multi-component reaction: Highly regioselective synthesis of functionalized 2-(diarylphosphoryl)-1,2-dihydro-pyridine derivatives

Kun Li et al.

Summary: A novel protocol has been developed for the construction of highly functionalized compounds via a one-pot cascade reaction. This method offers advantages such as environmental friendliness, simplicity, high yields, and potential biological activity of the products.

GREEN SYNTHESIS AND CATALYSIS (2022)

Article Biochemistry & Molecular Biology

SCF FBXW17 E3 ubiquitin ligase regulates FBXL19 stability and cell migration

Su Dong et al.

Summary: This study identified a new ubiquitin E3 ligase, SCFFBXW17, which ubiquitinates and induces FBXL19 degradation. FBXL19 plays a role in cell migration, and its degradation is mediated by SCFFBXW17.

JOURNAL OF CELLULAR BIOCHEMISTRY (2021)

Article Multidisciplinary Sciences

Establishment of high-throughput screening HTRF assay for identification small molecule inhibitors of Skp2-Cks1

Kaizhao Hu et al.

Summary: This study established an improved high-throughput screening platform to screen Skp2 inhibitors targeting Skp2-Cks1 interaction, which may offer a new therapeutic approach for cancer treatment.

SCIENTIFIC REPORTS (2021)

Review Cell Biology

Emerging Roles of SKP2 in Cancer Drug Resistance

Ting Wu et al.

Summary: Chemotherapy resistance poses a significant challenge in cancer treatment, and Skp2, as an E3 ligase, is closely associated with drug resistance and poor prognosis. This review summarizes the mechanisms through which Skp2 confers drug resistance, including its involvement in cell cycle regulation, DNA damage repair, and other pathways. New molecules targeting Skp2 interactions may hold promise for improving outcomes in cancer patients.
Review Biochemistry & Molecular Biology

The SCF Complex Is Essential to Maintain Genome and Chromosome Stability

Laura L. Thompson et al.

Summary: The SCF complex is a group of E3 ubiquitin ligase complexes that play crucial roles in regulating cellular processes such as gene transcription and the cell cycle. Aberrant expression or function of SCF complex members is associated with various cancer types, highlighting the importance of further characterizing their functions for potential therapeutic development.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Multidisciplinary

Aminocatalytic stereoselective synthesis of (E)-α-naphthyl enals via cross-coupling-like reaction of 1-bromo-2-naphthols with enals

Xixi Song et al.

Summary: A stereoselective reaction catalyzed by diphenyl prolinol TMS ether has been developed for the synthesis of (E)-α-naphthyl enals, with good yields and excellent stereoselectivities favoring E-isomers. This method allows for a wide range of aromatic enals and 1-bromo-2-naphthols, significantly expanding the scope of organocatalytic cross-coupling-like reactions by enabling sterically demanding substrates.

GREEN SYNTHESIS AND CATALYSIS (2021)

Review Oncology

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors

Gabriel LaPlante et al.

Summary: The ubiquitin-proteasome system plays a critical role in regulating protein levels and activity within cells, and its dysregulation is associated with various human diseases, including cancer. Targeting this system for inhibition in cancer therapy has shown promise, with proteasome inhibitors already being successfully used in multiple myeloma treatment. Furthermore, recent advancements in the development of targeted protein degradation strategies utilizing the UPS machinery, such as PROTACs, offer new avenues for cancer therapeutics.

CANCERS (2021)

Article Oncology

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Sonia Rodriguez et al.

LEUKEMIA (2020)

Review Biochemistry & Molecular Biology

The FBXL family of F-box proteins: variations on a theme

Bethany Mason et al.

OPEN BIOLOGY (2020)

Review Chemistry, Medicinal

Ubiquitin-proteasome system (UPS) as a target for anticancer treatment

Jinyoung Park et al.

ARCHIVES OF PHARMACAL RESEARCH (2020)

Review Medicine, Research & Experimental

F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects

Dinesh Singh Tekcham et al.

THERANOSTICS (2020)

Review Pharmacology & Pharmacy

Emerging drug development technologies targeting ubiquitination for cancer therapeutics

Gianluca Veggiani et al.

PHARMACOLOGY & THERAPEUTICS (2019)

Review Endocrinology & Metabolism

The role of SCF ubiquitin-ligase complex at the beginning of life

Jiayan Xie et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2019)

Review Multidisciplinary Sciences

Cellular quality control by the ubiquitin-proteasome system and autophagy

Christian Pohl et al.

SCIENCE (2019)

Review Biotechnology & Applied Microbiology

Deubiquitylating enzymes and drug discovery: emerging opportunities

Jeanine A. Harrigan et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Kuan-Chuan Pao et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Structure and Function of the 26S Proteasome

Jared A. M. Bard et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Review Oncology

Ubiquitin ligases in oncogenic transformation and cancer therapy

Daniela Senft et al.

NATURE REVIEWS CANCER (2018)

Article Biochemistry & Molecular Biology

Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases

Justin M. Reitsma et al.

Article Chemistry, Medicinal

Developing structure-activity relationships from an HTS hit for inhibition of the Cks1-Skp2 protein-protein interaction

Rajinder Singh et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Review Pharmacology & Pharmacy

Deubiquitinase inhibition as a cancer therapeutic strategy

Padraig D'Arcy et al.

PHARMACOLOGY & THERAPEUTICS (2015)

Review Biotechnology & Applied Microbiology

SCF ubiquitin ligase-targeted therapies

Jeffrey R. Skaar et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Biochemical Research Methods

High-Throughput Screening AlphaScreen Assay for Identification of Small-Molecule Inhibitors of Ubiquitin E3 Ligase SCFSkp2-Cks1

Dana Ungermannova et al.

JOURNAL OF BIOMOLECULAR SCREENING (2013)

Article Cell Biology

p27Kip1 as a prognostic factor in breast cancer: a systematic review and meta-analysis

Xiaoxiang Guan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2010)

Article Biochemistry & Molecular Biology

Skp2 suppresses p53-dependent apoptosis by inhibiting p300

Mayumi Kitagawa et al.

MOLECULAR CELL (2008)

Article Biochemistry & Molecular Biology

Structure-activity studies on diphenylpyrazine derivatives: A novel class of prostacyclin receptor agonists

Tetsuo Asaki et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubipuitin ligase

B Hao et al.

MOLECULAR CELL (2005)

Article Multidisciplinary Sciences

Degradation of p57Kip2 mediated by SCFSkp2 -: dependent ubiquitylation

T Kamura et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

N Zheng et al.

NATURE (2002)

Review Biotechnology & Applied Microbiology

The F-box protein family

Edward T. Kipreos et al.

GENOME BIOLOGY (2000)