相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structural modification aimed for improving solubility of lead compounds in early phase drug discovery
Bhanuranjan Das et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2022)
Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry
Hitoshi Sakurai et al.
PHARMACOPSYCHIATRY (2022)
Novel Glutamatergic Modulators for the Treatment of Mood Disorders: Current Status
Ioline D. Henter et al.
CNS DRUGS (2021)
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders
Christa C. Chrovian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2020)
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators
Christa C. Chrovian et al.
ACS MEDICINAL CHEMISTRY LETTERS (2019)
Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
Travis T. Wager et al.
ACS CHEMICAL NEUROSCIENCE (2016)
CNS Drug Design: Balancing Physicochemical Properties for Optimal Brain Exposure
Zoran Rankovic
JOURNAL OF MEDICINAL CHEMISTRY (2015)
NMDA Receptor Function During Senescence: Implication on Cognitive Performance
Ashok Kumar
FRONTIERS IN NEUROSCIENCE (2015)
Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System
Raj Badhan et al.
Pharmaceutics (2014)
Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry
Minoru Ishikawa et al.
JOURNAL OF MEDICINAL CHEMISTRY (2011)
Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes
Travis T. Wager et al.
ACS CHEMICAL NEUROSCIENCE (2010)
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis et al.
PHARMACOLOGICAL REVIEWS (2010)
Glutamatergic Modulators: The Future of Treating Mood Disorders?
Carlos Zarate et al.
HARVARD REVIEW OF PSYCHIATRY (2010)
Generation of a set of simple, interpretable ADMET rules of thumb
M. Paul Gleeson
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Novel drugs and therapeutic targets for severe mood disorders
Sanjay J. Mathew et al.
NEUROPSYCHOPHARMACOLOGY (2008)
NMDA receptor subunits: function and pharmacology
Pierre Paoletti et al.
CURRENT OPINION IN PHARMACOLOGY (2007)
Ionotropic and metabotropic glutamate receptor structure and pharmacology
JNC Kew et al.
PSYCHOPHARMACOLOGY (2005)
Automated assignment of high-resolution collisionally activated dissociation mass spectra using a systematic bond disconnection approach
AW Hill et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2005)