期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 66, 期 13, 页码 8580-8599出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.3c00255
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The study focused on the anticancer properties of dipicolinate-basedvanadium(IV) complexes with different diimines. These complexes showed high cytotoxic effect against HCT116-DoxR cells and induced cell death through apoptosis and autophagy pathways. They also interacted with BSA protein and did not promote tumor cell migration or angiogenesis.
The work is focused on anticancer properties of dipicolinate(dipic)-basedvanadium(IV) complexes [VO(dipic)((NN)-N-boolean AND)] bearingdifferent diimines (2-(1H-imidazol-2-yl)pyridine,2-(2-pyridyl)benzimidazole, 1,10-phenanthroline-5,6-dione, 1,10-phenanthroline,and 2,2 '-bipyridine), as well as differently 4,7-substituted1,10-phenanthrolines. The antiproliferative effect of V(IV) systemswas analyzed in different tumors (A2780, HCT116, and HCT116-DoxR)and normal (primary human dermal fibroblasts) cell lines, revealinga high cytotoxic effect of [VO(dipic)((NN)-N-boolean AND)] with4,7-dimethoxy-phen (5), 4,7-diphenyl-phen (6), and 1,10-phenanthroline (8) against HCT116-DoxR cells.The cytotoxicity differences between these complexes can be correlatedwith their different internalization by HCT116-DoxR cells. Worthyof note, these three complexes were found to (i) induce cell deaththrough apoptosis and autophagy pathways, namely, through ROS production;(ii) not to be cytostatic; (iii) to interact with the BSA protein;(iv) do not promote tumor cell migration or a pro-angiogenic capability;(v) show a slight in vivo anti-angiogenic capability,and (vi) do not show in vivo toxicity in a chickenembryo.
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