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Letter
Infectious Diseases
Annalisa Mondi et al.
JOURNAL OF INFECTION
(2023)
Article
Infectious Diseases
Chiara Agrati et al.
Summary: This study investigated the immune response against monkeypox virus in patients with laboratory-confirmed monkeypox. The results showed a reduction in CD4+ T cells and an increase in CD8+ T cells during the early stage of the infection. The patients developed a poxvirus-specific immune response, and inflammatory cytokines remained elevated even after recovery.
LANCET INFECTIOUS DISEASES
(2023)
Article
Virology
Lulan Wang et al.
Summary: Monkeypox virus (MPXV) has been circulating in West and Central Africa. Recent outbreaks in nonendemic countries were analyzed, revealing that the MPXV-2022 strains belong to the same lineage as the 2018 strain with several new mutations. Some specific proteins were found to be more prone to mutation in the MPXV genome. This study provides insights into the ongoing MPXV outbreak and identifies novel mutations for further research.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Elnaz Khani et al.
Summary: This study reviewed the available evidence on virology and treatment approaches for monkeypox and provided guidance for patient care and future studies. Tecovirimat was found to be the most promising medication for monkeypox treatment, but the risk of resistance should be considered.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Isaac Nunez et al.
Article
Medicine, General & Internal
Oriol Mitja et al.
Summary: In the 2022 multicountry mpox outbreak, 38-50% of those affected were people living with HIV. Clinical outcomes and mortality were worse in people with more advanced HIV.
Article
Infectious Diseases
David Ulaeto et al.
LANCET INFECTIOUS DISEASES
(2023)
Letter
Immunology
Eric Dumonteil et al.
EMERGING INFECTIOUS DISEASES
(2023)
Letter
Immunology
Hanna Vauhkonen et al.
Summary: Monkeypox virus was introduced to Finland in late May-early June 2022. Analysis of viral genome in a patient's sample showed a major variant with 3 lineage B.1.3-specific mutations and a minor variant with ancestral B.1 nucleotides. The results suggest ongoing evolution mediated by APOBEC3 enzyme or co-infection.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Andrea Antinori et al.
Summary: Since May 2022, there has been an ongoing monkeypox outbreak in non-endemic countries. Four cases in young adult men in Italy, who engaged in condomless sexual intercourse, were reported. The patients are in good clinical condition and do not require specific antiviral drugs. Monkeypox viral DNA was detected in seminal fluid samples. The possibility of sexual transmission of monkeypox virus needs to be investigated.
Article
Infectious Diseases
Yael Hammerschlag et al.
Summary: A case of monkeypox was confirmed in an HIV-positive individual receiving antiretroviral therapy in Australia, with the patient developing systemic illness and disseminated rash necessitating hospitalization.
Article
Pharmacology & Pharmacy
John G. Rizk et al.
Summary: Human monkeypox is a zoonotic disease similar to smallpox. It can be transmitted through contact with infected animals, direct contact, respiratory droplets, and contaminated objects. Various medical countermeasures, including vaccines and antiviral drugs, are available for the treatment of monkeypox.
Article
Microbiology
Gaële Frenois-Veyrat et al.
Summary: The largest monkeypox virus outbreak ever recorded outside of Africa has been reported. Researchers have isolated and sequenced a virus from the first diagnosed MPXV case in France (May 2022). The study found that tecovirimat, an approved drug by the US Food and Drug Administration, is effective against this virus at nanomolar concentrations, while cidofovir only works at micromolar concentrations. These results support the use of tecovirimat in ongoing human clinical trials.
NATURE MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
John P. Thornhill et al.
Summary: This report describes 528 cases of monkeypox in 16 countries. Common clinical findings include rash, mucosal lesions, fever, lethargy, and lymphadenopathy. Few patients required hospitalization.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Editorial Material
Infectious Diseases
David O. Ulaeto et al.
Article
Infectious Diseases
Aisling M. Vaughan et al.
Summary: Since the first non-travel-associated cluster of monkeypox cases was reported by the United Kingdom in May 2022, 41 countries in the WHO European Region have reported 21,098 cases and two deaths by August 23, 2022. Nowcasting indicates a plateauing in case notifications. The majority of cases (97%) are among men who have sex with men (MSM), and the symptoms present as atypical rash illness. The main mode of transmission is through close contact during sexual activities. Few cases are reported among women and children. Targeted interventions for high-risk groups are necessary to halt further transmission.
Review
Virology
Daniele Focosi et al.
Summary: Monkeypox virus has caused human monkeypox in the tropical rainforests of Africa for decades, but recent sustained outbreaks have occurred across multiple continents, mostly in males having sex with males.
REVIEWS IN MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yong Huang et al.
Summary: Monkeypox is a zoonotic disease caused by monkeypox virus and has recently spread beyond endemic areas. It has been declared a public health emergency of international concern due to the increasing number of cases. This review provides an overview of monkeypox epidemiology, transmission patterns, viral infection mechanisms, clinical characteristics, diagnostic methods, and treatment measures. It also emphasizes the need for antiviral drugs and vaccines to control the disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Microbiology
Jakob Trimpert et al.
NATURE MICROBIOLOGY
(2019)
Article
Infectious Diseases
Sophie Duraffour et al.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2015)
Article
Immunology
Jeffrey R. Kugelman et al.
EMERGING INFECTIOUS DISEASES
(2014)
Article
Biochemical Research Methods
Heng Li et al.
Article
Biochemical Research Methods
Heng Li et al.
