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Article
Biochemistry & Molecular Biology
Qian Wang et al.
Summary: The BQ and XBB subvariants of SARS-CoV-2 Omicron, with additional spike mutations, are rapidly expanding and have altered antibody evasion properties. Neutralization of BQ.1, BQ.1.1, XBB, and XBB.1 by vaccinated individuals and infected persons' sera was significantly impaired, including those boosted with a WA1/BA.5 bivalent mRNA vaccine. The titers against BQ and XBB subvariants were much lower than observed before, indicating that these subvariants pose a serious threat to current COVID-19 vaccines and render all authorized antibodies inactive.
Article
Cell Biology
Kathryn Westendorf et al.
Summary: A monoclonal antibody named LY-CoV1404 has been successfully isolated, which demonstrates highly potent neutralization against multiple variants of the SARS-CoV-2 virus. The binding site of LY-CoV1404 remains relatively conserved, allowing it to maintain its activity. This finding suggests that LY-CoV1404 has the potential to be an effective therapeutic agent against all known variants.
Article
Cell Biology
Yunlong Cao et al.
Summary: This study presents a rational approach for identifying broad-spectrum neutralizing antibody (NAbs) cocktails against fast-evolving SARS-CoV-2. By targeting non-immunodominant receptor-binding domain (RBD) epitopes and conserved sites associated with critical viral functions, the researchers identified a promising antibody cocktail with the potential to neutralize various sarbecoviruses, including the Omicron variant.
Article
Microbiology
Tyler N. Starr et al.
Summary: SARS-CoV-2 virus continues to undergo mutations in the spike receptor-binding domain, affecting biochemical properties related to ACE2 receptor binding, folding stability, and antibody recognition. This study investigates the effects of these mutations in the Omicron BA.1 and BA.2 variants, showing potential changes in function compared to the ancestral strain. The research highlights the importance of ongoing surveillance and understanding the mutational landscape for effective monitoring and control of the virus.
Letter
Infectious Diseases
Maxime Hentzien et al.
LANCET INFECTIOUS DISEASES
(2022)
Article
Microbiology
Craig Fenwick et al.
Summary: A monoclonal antibody named P2G3 isolated from a previously infected vaccinated donor shows strong neutralizing activity against the SARS-CoV-2 Omicron variant and provides complete prophylactic or therapeutic protection when used alone or in combination with another antibody. The unique epitope of P2G3 may have important implications for combating the Omicron variant.
NATURE MICROBIOLOGY
(2022)
Article
Microbiology
Akatsuki Saito et al.
Summary: The SARS-CoV-2 Omicron BA.2.75 variant, emerged in May 2022, demonstrates distinct virological properties compared to its ancestors BA.2 and BA.5. It exhibits higher effective reproduction number and sensitivity to antibodies, as well as greater affinity for the human receptor ACE2 and pathogenicity in hamsters.
CELL HOST & MICROBE
(2022)
Letter
Infectious Diseases
Fanchong Jian et al.
LANCET INFECTIOUS DISEASES
(2022)
Article
Microbiology
Devon A. Gregory et al.
Summary: Wastewater-based epidemiology is an effective method for tracking the appearance and spread of SARS-COV-2 lineages in communities. In 2021, novel SARS-COV-2 RBD lineages were consistently detected in wastewater samples from 9 sewersheds in the US, containing multiple amino acid substitutions and sharing similarities with the Omicron variant. These lineages, potentially originating from long-term patient infections or animal reservoirs, demonstrate greater genetic diversity than commonly observed.
Letter
Infectious Diseases
Maxime Hentzien et al.
LANCET INFECTIOUS DISEASES
(2022)
Article
Virology
Yang Yang et al.
Summary: The study found that neferine effectively inhibits infection by various coronaviruses by blocking host calcium channels, thus showing potential as a promising lead for pan-coronaviruses therapeutic drug development.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemical Research Methods
Peng Yang et al.
Summary: The study focused on constructing a SARS-CoV-2 pseudovirus particle system in a BSL-2 laboratory for infection studies, revealing key conditions for improving pseudovirus titer and the system's efficacy in evaluating infection inhibitors. Different cell lines showed varying susceptibility to SARS-CoV-2 pseudovirus particles, indicating potential for future research on entry mechanisms and inhibitors.
JOURNAL OF VIROLOGICAL METHODS
(2021)
