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Statins in hospitalized COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials

JOURNAL OF MEDICAL VIROLOGY (2023)

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Article Medicine, General & Internal

Colchicine and high-intensity rosuvastatin in the treatment of non-critically ill patients hospitalised with COVID-19: a randomised clinical trial

Tayyab Shah et al.

Summary: This study aimed to evaluate the effect of colchicine and high-intensity rosuvastatin in addition to standard of care on the progression of COVID-19 disease in hospitalized patients. The study found no significant difference in the progression of the disease and thromboembolic events within 30 days.

BMJ OPEN (2023)

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Article Virology

Survival of the hospitalized patients with COVID-19 receiving atorvastatin: A randomized clinical trial

Majid Ghafoori et al.

Summary: According to this study, adding atorvastatin to standard therapy increased the duration of hospitalization and had negative effects on symptom improvement in hospitalized patients with COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2022)

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Review Hematology

Role of therapeutic plasma exchange in the management of COVID-19-induced cytokine storm syndrome

Mickael Beraud et al.

Summary: Therapeutic plasma exchange (TPE) appears to be a safe intervention with immunomodulatory effects and potential clinical benefits for patients with cytokine storm syndrome (CSS) induced by COVID-19. However, more high-quality randomized controlled clinical trials are needed to confirm its clinical benefits, and clear criteria should be established to identify CSS patients who may benefit from TPE.

TRANSFUSION AND APHERESIS SCIENCE (2022)

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Article Infectious Diseases

Statin and aspirin as adjuvant therapy in hospitalised patients with SARS-CoV-2 infection: a randomised clinical trial (RESIST trial)

Nirmal Ghati et al.

Summary: This study demonstrates that additional treatment with aspirin, atorvastatin, or a combination of the two does not prevent clinical deterioration in patients with mild to moderate COVID-19 infection, and there were no other significant benefits observed.

BMC INFECTIOUS DISEASES (2022)

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Article Medicine, Research & Experimental

Managing endothelial dysfunction in COVID-19 with statins, beta blockers, nicorandil, and oral supplements: A pilot, double-blind, placebo-controlled, randomized clinical trial

Kamal Matli et al.

Summary: This study investigated whether specific drug treatment for endothelial dysfunction in COVID-19 patients could improve clinical outcomes. The results showed that this treatment did not decrease the recovery time of patients, whether in terms of the need for mechanical ventilation or ICU admission, all-cause mortality, or occurrence of side effects.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2022)

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Letter Medicine, General & Internal

Effects of statins on clinical outcomes in hospitalized patients with COVID-19

Paulo Ricardo Martins-Filho et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2022)

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Article Peripheral Vascular Disease

Benefits of continuous positive airway pressure on blood pressure in patients with hypertension and obstructive sleep apnea: a meta-analysis

Wenli Shang et al.

Summary: This meta-analysis examined the effects of CPAP on blood pressure in patients with hypertension and OSA. The results showed that CPAP treatment significantly reduced blood pressure levels in these patients, including 24-hour systolic and diastolic blood pressure, daytime and nighttime blood pressure, and office blood pressure.

HYPERTENSION RESEARCH (2022)

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Review Nutrition & Dietetics

Biological Actions, Implications, and Cautions of Statins Therapy in COVID-19

Chengyu Liu et al.

Summary: Individuals with obesity have shown worse prognosis and higher mortality in the COVID-19 pandemic. Dyslipidemia, a common condition in obese individuals, plays a major role in the severity of COVID-19. The use of statins, lipid-regulating drugs, has been associated with a reduced risk of progressing to severe illness and in-hospital death in COVID-19 patients. However, caution should be taken due to potential side effects and concerns about interference with COVID-19 vaccines. Further clinical trials are needed to fully understand the benefits, harms, and mechanisms of statin use in the context of COVID-19.

FRONTIERS IN NUTRITION (2022)

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Review Infectious Diseases

Benefits of plasma exchange on mortality in patients with COVID-19 a systematic review and meta-analysis

Jinlv Qin et al.

Summary: This study conducted a systematic review and meta-analysis and found that therapeutic plasma exchange (TPE) has a significant effect on reducing mortality in patients with COVID-19. It is recommended to consider plasma exchange therapy for hospitalized patients with COVID-19.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

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Review Medicine, General & Internal

Systematic Review and Meta-Analysis of Statin Use and Mortality, Intensive Care Unit Admission and Requirement for Mechanical Ventilation in COVID-19 Patients

Ut-Sam Lao et al.

Summary: There is mounting evidence that the use of statins is associated with reduced mortality, ICU admission, and mechanical ventilation in COVID-19 patients. However, current studies mainly focus on the use of statins before or after hospital admission, and more research is needed on the use of statins after developing COVID-19 infection.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Medicine, General & Internal

Effectiveness of rosuvastatin plus colchicine, emtricitabine/tenofovir and combinations thereof in hospitalized patients with COVID-19: a pragmatic, open-label randomized trial

H. G. Gaitan-Duarte et al.

Summary: This study aimed to evaluate the effectiveness and safety of rosuvastatin plus colchicine, emtricitabine/tenofovir, and their combined use in hospitalized patients with COVID-19. The findings suggest that the combined use of FTC/TDF+COLCH+ROSU reduces the risk of 28-day mortality in these patients compared to standard care. More randomized controlled trials are needed to further assess the potential advantages of this treatment combination.

ECLINICALMEDICINE (2022)

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Article Infectious Diseases

Plasma exchange in the treatment of complex COVID-19-related critical illness: controversies and perspectives

Ziad A. Memish et al.

Summary: Since the outbreak at the end of 2019, COVID-19 has caused millions of cases and hundreds of thousands of deaths worldwide. Therapeutic plasma exchange (TPE) shows promise in managing life-threatening COVID-19, but its immunosuppressive effects and safety need further validation.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

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Article Multidisciplinary Sciences

Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19

Aakriti Gupta et al.

Summary: The use of statins in patients hospitalized with COVID-19 is associated with a lower risk of inpatient mortality, potentially due to their anti-inflammatory and antithrombotic properties.

NATURE COMMUNICATIONS (2021)

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Article Critical Care Medicine

Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial

Jozefien Declercq et al.

Summary: In this trial evaluating IL-1 and IL-6 blockade treatment in COVID-19 patients, it did not shorten the time to clinical improvement, and there were no significant differences in mortality rate and incidence of serious adverse events between the groups.

LANCET RESPIRATORY MEDICINE (2021)

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Review Cardiac & Cardiovascular Systems

Statin use and mortality in COVID-19 patients: Updated systematic review and meta-analysis

Anastasios Kollias et al.

Summary: A systematic review was conducted to analyze the relationship between statin therapy and mortality in COVID-19 patients, showing that statin therapy was associated with about a 35% decrease in the adjusted risk of mortality.

ATHEROSCLEROSIS (2021)

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Article Cardiac & Cardiovascular Systems

Atorvastatin therapy in COVID-19 adult inpatients: A double-blind, randomized controlled trial

Lotfollah Davoodi et al.

Summary: This study suggests that atorvastatin + lopinavir/ritonavir may be more effective in treating COVID-19 adult hospitalized patients compared to lopinavir/ritonavir alone. There were significant reductions in C-reactive protein levels and duration of hospitalization in the atorvastatin + lopinavir/ritonavir group.

IJC HEART & VASCULATURE (2021)

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Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

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Review Immunology

COVID-19 pathophysiology: A review

Koichi Yuki et al.

CLINICAL IMMUNOLOGY (2020)

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Article Cell Biology

In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19

Xiao-Jin Zhang et al.

CELL METABOLISM (2020)

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Review Infectious Diseases

The pathogenesis and treatment of the 'Cytokine Storm' in COVID-19

Qing Ye et al.

JOURNAL OF INFECTION (2020)

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Review Public, Environmental & Occupational Health

Nasal disinfection for the prevention and control of COVID-19: A scoping review on potential chemo-preventive agents

L. Cegolon et al.

INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH (2020)

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Review Critical Care Medicine

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

Daniel E. Leisman et al.

LANCET RESPIRATORY MEDICINE (2020)

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Review Immunology

Statins: a viable candidate for host-directed therapy against infectious diseases

Suraj P. Parihar et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Medicine, General & Internal

The Cochrane Collaboration's tool for assessing risk of bias in randomised trials

Julian P. T. Higgins et al.

BMJ-BRITISH MEDICAL JOURNAL (2011)

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Article Medicine, General & Internal

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Alessandro Liberati et al.

ANNALS OF INTERNAL MEDICINE (2009)

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Article Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

ANNALS OF INTERNAL MEDICINE (2009)

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Review Cardiac & Cardiovascular Systems

The pleiotropic effects of statins on endothelial function, vascular inflammation, immunomodulation and thrombogenesis

A. Blum et al.

ATHEROSCLEROSIS (2009)

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