4.1 Article

Improved use of faecal immunochemical tests for haemoglobin in the Scottish bowel screening programme

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Faecal occult blood loss accurately predicts future detection of colorectal cancer. A prognostic model

Reinier G. S. Meester et al.

Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Article Oncology

Factors associated with interval colorectal cancer after negative FIT: Results of two screening rounds in the Dutch FIT-based CRC screening program

Emilie C. H. Breekveldt et al.

Summary: The interval colorectal cancer (CRC) rate after negative fecal immunochemical testing (FIT) is an important quality indicator of CRC screening programs. Our study analyzed the outcomes of a FIT-based CRC screening program in the Netherlands, showing low incidence of interval CRC and high FIT-sensitivity. Risk-stratified CRC screening based on prior fecal hemoglobin concentration (f-Hb) may further optimize the screening program.

INTERNATIONAL JOURNAL OF CANCER (2023)

Article Oncology

Risk-stratified selection to colonoscopy in FIT colorectal cancer screening: development and temporal validation of a prediction model

Mette Kielsholm Thomsen et al.

Summary: This study used registry data from the Danish CRC screening programme to develop a risk-based selection of participants for diagnostic colonoscopy. The results showed that risk-stratified FIT screening using a risk cut-off instead of a FIT cut-off can slightly improve the selection of individuals at highest risk of CRC and AN.

BRITISH JOURNAL OF CANCER (2022)

Article Oncology

Optimizing the colorectal cancer screening programme using faecal immunochemical test (FIT) in Flanders, Belgium from the interval cancer perspective

Thuy Ngan Tran et al.

Summary: Interval cancer after faecal immunochemical test (FIT) screening is a critical issue in colorectal cancer (CRC) screening. This study identified factors associated with FIT-ICs and explored the impact of lowering FIT cut-off or shortening screening interval. The results showed that FIT-ICs were more common in women, older age, right-sided location, advanced stage, and high grade. Lowering the FIT cut-off or shortening the screening interval would have minimal impact on FIT-ICs.

BRITISH JOURNAL OF CANCER (2022)

Article Public, Environmental & Occupational Health

Faecal haemoglobin concentrations in women and men diagnosed with colorectal cancer in a national screening programme

Gavin R. C. Clark et al.

Summary: There is evidence that colorectal cancer screening using faecal haemoglobin is less effective in women than men, with women having lower faecal haemoglobin concentrations compared to men. This gender difference in faecal haemoglobin concentrations persists across different stages and sites of colorectal cancer. To address gender inequalities, screening programs may need to consider using different faecal haemoglobin concentration thresholds for women and men.

JOURNAL OF MEDICAL SCREENING (2022)

Article Public, Environmental & Occupational Health

Optimizing screening with faecal immunochemical test for both sexes Cost-effectiveness analysis from Finland

Sirpa Heinavaara et al.

Summary: This study modeled the cost-effectiveness of sex-specific FIT screening strategies in Finland and evaluated the optimal strategies. The results showed that annual FIT screening with a cut-off of 25μg/g for men aged 50-79 and with a cut-off of 10μg/g for women aged 55-69 was optimal. This strategy significantly reduced the incidence and mortality of colorectal cancer.

PREVENTIVE MEDICINE (2022)

Article Medical Laboratory Technology

A comparison of the faecal haemoglobin concentrations and diagnostic accuracy in patients suspected with colorectal cancer and serious bowel disease as reported on four different faecal immunochemical test systems

Sally C. Benton et al.

Summary: This study assessed the comparability of faecal haemoglobin concentrations obtained with four quantitative FIT systems at different thresholds. The results showed differences between systems at lower thresholds, highlighting the need for further understanding of their clinical impact and efforts to minimize these differences.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Article Gastroenterology & Hepatology

Varying fecal immunochemical test screening cutoffs by age and gender: a way to increase detection rates and reduce the number of colonoscopies

Sisse Helle Njor et al.

Summary: This study aimed to improve population-based CRC screening by using different cutoff values for different age and gender groups. The results showed that adjusting the cutoff values could decrease the number of needed colonoscopies, increase overall sensitivity and specificity, and detect more cancers and adenomas. However, this approach also increased inequality in sensitivity and specificity, suggesting the need for alternative strategies.

GASTROINTESTINAL ENDOSCOPY (2022)

Review Medical Laboratory Technology

Strategies to minimise the current disadvantages experienced by women in faecal immunochemical test-based colorectal cancer screening

Gavin R. C. Clark et al.

Summary: Women are at a disadvantage in colorectal cancer screening due to lower faecal haemoglobin concentrations, leading to poorer outcomes. Risk scoring strategies that consider sex have not been extensively tested or introduced. Governments and agencies should prioritize allocating resources to implement simple strategies, such as using different haemoglobin thresholds, to achieve equal positivity in both sexes.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2022)

Article Medical Laboratory Technology

Do faecal test-based colorectal cancer screening pilots provide data that are reflected in subsequent programmes? Evidence from interval cancer proportions

Gavin R. C. Clark et al.

Summary: This study aims to compare the proportions of interval cancers in different colorectal cancer screening programs and evaluate whether the pilot provides data that is reflected in the subsequent program.

ANNALS OF CLINICAL BIOCHEMISTRY (2022)

Article Public, Environmental & Occupational Health

Individualized faecal immunochemical test cut-off based on age and sex in colorectal cancer screening

Tim L. Kortlever et al.

Summary: Calculating individualized FIT cut-offs based on age and sex can improve the accuracy of colorectal cancer screening by ensuring a comparable risk of advanced neoplasia prior to colonoscopy.

PREVENTIVE MEDICINE REPORTS (2021)

Article Medicine, General & Internal

Piloting gender-oriented colorectal cancer screening with a faecal immunochemical test: population-based registry study from Finland

Tytti Sarkeala et al.

Summary: The relaunched colorectal cancer screening programme with different cut-offs for men and women showed higher participation rates for women and different detection rates for CRC and advanced adenoma between genders. The results suggest that gender-specific protocols in organized CRC screening may lead to more effective outcomes.

BMJ OPEN (2021)

Article Public, Environmental & Occupational Health

Gender-specific cut-off levels in colorectal cancer screening with fecal immunochemical test: A population-based study of colonoscopy findings and costs

Hanna Ribbing Wilen et al.

Summary: The gender-specific cut-off levels of fecal hemoglobin in the population-based Swedish regional colorectal cancer screening program resulted in higher detection rates of CRC in women, despite a minor increase in screening costs.

JOURNAL OF MEDICAL SCREENING (2021)

Article Medical Laboratory Technology

Faecal haemoglobin distributions by sex, age, deprivation and geographical region: consequences for colorectal cancer screening strategies

Gavin R. C. Clark et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2020)

Article Gastroenterology & Hepatology

Scottish Bowel Screening Programme colonoscopy quality - scope for improvement?

A. J. Quyn et al.

COLORECTAL DISEASE (2018)

Review Gastroenterology & Hepatology

Clinical and Biological Features of Interval Colorectal Cancer

Yu Mi Lee et al.

CLINICAL ENDOSCOPY (2017)

Review Gastroenterology & Hepatology

Advances in Fecal Occult Blood Tests: The FIT Revolution

Graeme P. Young et al.

DIGESTIVE DISEASES AND SCIENCES (2015)

Article Public, Environmental & Occupational Health

Deprivation and faecal haemoglobin: implications for bowel cancer screening

Jayne Digby et al.

JOURNAL OF MEDICAL SCREENING (2014)

Article Gastroenterology & Hepatology

Clinical outcomes using a faecal immunochemical test for haemoglobin as a first-line test in a national programme constrained by colonoscopy capacity

Robert J. C. Steele et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2013)

Review Gastroenterology & Hepatology

Cochrane systematic review of colorectal cancer screening using the fecal occult blood test (Hemoccult): An update

Paul Hewitson et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2008)