期刊
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
卷 36, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2023.2204392
关键词
Systemic lupus; pregnancy outcomes; Caribbean; auto-immune
This study analyzed pregnancy outcomes in a Afro-Caribbean cohort of women with systemic lupus erythematosus (SLE). The results showed a live birth rate of 87.5%, spontaneous miscarriage rate of 10.7%, and no neonatal deaths. Prednisone, a steroid medication, was the most commonly used drug and was associated with adverse fetal/neonatal outcomes.
Background Systemic Lupus Erythematosus (SLE) is a chronic autoimmune multi-system disorder frequently affecting black women of childbearing age. No published data exist on the obstetric outcomes in a Caribbean population. Objective We analyzed pregnancy outcomes in an Afro-Caribbean cohort of women with SLE at a tertiary university hospital. Methods A retrospective cohort study was performed of all pregnant women with SLE prior to pregnancy from January 1990 to December 2021 at the University Hospital of the West Indies (UHWI), Jamaica. Maternal rheumatologic, obstetric, fetal/neonatal data were analyzed. Descriptive statistical analyses were performed. To determine if outcomes were associated with various factors, Spearman's rho was followed by logistic regression analysis to estimate unadjusted odds ratios with statistical significance at p < 0.05. Results A total of 56 pregnancies in 47 women were identified with SLE. Live births were 87.5%, with 10.7% spontaneous miscarriages and no neonatal deaths. Prednisone was the most used drug in 67.9% of patients. 85% of women had an adverse outcome with an adverse fetal outcome occurring in 55% of cases. Prednisone was associated with an adverse fetal/neonatal outcome (Spearman's rho = 0.38; p = .004). Conclusion In this first Caribbean series on SLE in pregnancy, reasonably successful pregnancy outcomes are achievable in Afro-Caribbean women managed in multidisciplinary centers.
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