☆ 4.7 Review

Function-oriented design: A novel strategy for advanced biomedical materials

JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY (2023)

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News Item Multidisciplinary Sciences

FIRST PIG-TO-HUMAN HEART TRANSPLANT: WHAT CAN SCIENTISTS LEARN?

Sara Reardon

NATURE (2022)

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Article Cell Biology

Exercise-induced piezoelectric stimulation for cartilage regeneration in rabbits

Yang Liu et al.

Summary: A biodegradable piezoelectric poly(l-lactic acid) (PLLA) nanofiber scaffold can act as a battery-less electrical stimulator to promote chondrogenesis and cartilage regeneration. With the use of this scaffold and exercise treatment, hyaline-cartilage regeneration and complete healing can be achieved after 1 to 2 months.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Review Engineering, Biomedical

The horizon of bone organoid: A perspective on construction and application

Shuangshuang Chen et al.

Summary: The repair and regeneration of bone defects caused by various factors have always been a key issue in clinical practice. Bone tissue engineering technology has greatly accelerated the speed and quality of bone regeneration by providing functional scaffold materials and seed cells. However, the complicated bone metabolism mechanism poses challenges to research in bone regeneration. Organoids, as a new concept, show promising application prospects in organ development, drug screening, and mechanism study.

BIOACTIVE MATERIALS (2022)

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Review Genetics & Heredity

Single-cell atlases: shared and tissue-specific cell types across human organs

Rasa Elmentaite et al.

Summary: The development of single-cell and spatial transcriptomics methods has enabled the conception of the Human Cell Atlas initiative, aiming to generate an integrated map of all cells in the human body. By studying human tissues using single-cell gene expression data, we are gaining insights into the commonalities and tissue-specific features of major and supportive cell types within human organs.

NATURE REVIEWS GENETICS (2022)

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Article Orthopedics

Injectable hydrogel with nucleus pulposus-matched viscoelastic property prevents intervertebral disc degeneration

Haoruo Jia et al.

Summary: The study aims to develop a novel hydrogel with high injectability, biocompatibility and mechanical adaptability to the intervertebral disc environment, using a simple chemistry and method. The results show that the hydrogel has therapeutic effects on intervertebral disc degeneration and disc defect repair, demonstrating great translational potential for minimally invasive clinical treatment.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2022)

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Review Cell & Tissue Engineering

Skeletal muscle differentiation of human iPSCs meets bioengineering strategies: perspectives and challenges

Federica Iberite et al.

Summary: This article highlights the potential of combining induced pluripotent stem cells (iPSCs) with bioengineering strategies in skeletal muscle tissue engineering. The main topics discussed include the myogenic process, induction methods for iPSCs, and technologies to provide cells with biophysical stimuli and biofabrication strategies.

NPJ REGENERATIVE MEDICINE (2022)

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Article Orthopedics

Regulation of differentiation of annulus fibrosus-derived stem cells using heterogeneous electrospun fibrous scaffolds

Pinghui Zhou et al.

Summary: This study demonstrates that fibrous scaffolds with different fiber sizes promote the differentiation of AFSCs into specific cell types similar to those in different regions of the annulus fibrosus. By regulating cell differentiation and utilizing the physical cues of scaffolds, it is possible to create engineered tissues with complex hierarchical structures.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2021)

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Article Materials Science, Biomaterials

Substrate Topography Regulates Differentiation of Annulus Fibrosus-Derived Stem Cells via CAV1-YAP-Mediated

Genglei Chu et al.

Summary: In this study, fibrous poly(ether carbonate urethane)urea (PECUU) scaffolds with various fiber sizes were fabricated to mimic the microstructural feature of native annulus fibrosus (AF) and control the differentiation of AF-derived stem cells (AFSCs) by regulating topographical cues. The research demonstrated that the topography-dependent gene expression in AFSCs approximated the biochemical profile of AF tissue in different zones, indicating that tuning the fiber size of scaffolds can effectively induce changes in cell shape, adhesions, and extracellular matrix expression. The study may offer new insights for designing novel materials for AF tissue regeneration based on the activation of the CAV1-YAP mechanotransduction axis.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Cell Biology

Take My Bone Away? Hypoxia and bone: A narrative review

Scott S. Hannah et al.

Summary: Hypoxia can have significant impacts on bone health, with bone cells exhibiting unique responses to hypoxic stimuli. Changes in bone metabolism induced by hypoxia may be mediated through multiple mechanisms.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

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Article Hematology

Cardiac and lung endothelial cells in response to fluid shear stress on physiological matrix stiffness and composition

Cydnee Bacci et al.

Summary: This study demonstrates the importance of substrate stiffness in regulating tissue-specific endothelial cell response to shear stress, potentially due to differences in their native microenvironments. Furthermore, cardiac and lung endothelial cell response to shear stress was significantly influenced by the type of coating used.

MICROCIRCULATION (2021)

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Article Biochemistry & Molecular Biology

Building inner ears: recent advances and future challenges for in vitro organoid systems

Wouter H. van der Valk et al.

Summary: While inner ear disorders are common, our ability to intervene and recover their sensory function is limited. Developing in vitro models such as inner ear organoids could aid in identifying new regenerative drugs and gene therapies. To enhance the applicability of in vitro inner ear models, a more holistic view focusing on the broader diversity of neuroglial and mesenchymal cell types is needed.

CELL DEATH AND DIFFERENTIATION (2021)

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Article Cell Biology

Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration

Molong Qu et al.

Summary: This study established a novel culture system for intestinal organoids, identified regenerative stem cell populations, and found VPA and EPZ6438 were crucial for epigenome reprogramming and regeneration.

CELL RESEARCH (2021)

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Review Biotechnology & Applied Microbiology

Engineering precision nanoparticles for drug delivery

Michael J. Mitchell et al.

Summary: The development of nanoparticles has shown promising clinical applications, overcoming the limitations of therapeutic interventions and biological barriers. Precision therapies have enhanced treatment efficacy through personalized interventions. Advancements in nanoparticle design aim to optimize drug delivery, improving efficacy in general applications and enabling tailored designs for precision applications.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Oncology

A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation

Yuan-Hung Lo et al.

Summary: Mutations in ARID1A are common in human cancer, but the oncogenic consequences of these mutations remain unclear. Using CRISPR/Cas9, researchers induced dysplasia, tumorigenicity, and mucinous differentiation in human gastric organoids, providing insights into the pathways affected by ARID1A mutation. Further analysis showed vulnerability of ARID1A-deficient organoids to inhibition of BIRC5/survivin, highlighting this pathway as crucial for early-stage gastric tumorigenesis.

CANCER DISCOVERY (2021)

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Article Multidisciplinary Sciences

Computational fluid dynamics for enhanced tracheal bioreactor design and long-segment graft recellularization

Hankyu Lee et al.

Summary: This study utilized computational fluid dynamics to redesign the fluid delivery system of a trachea bioreactor and improve the perfusion cell seeding protocol to promote uniform cell deposition. The research demonstrated that low rates of rotation provide more uniform cell deposition patterns and enhance re-epithelialization of long segment tracheal grafts. Lessons learned from this study can be applied to culturing of any tissue engineered tubular scaffold.

SCIENTIFIC REPORTS (2021)

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Article Engineering, Biomedical

A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction

Binbin Sun et al.

Summary: An anatomically correct IVD scaffold was fabricated using 3D bioprinting technology, which successfully regenerated the structure and function of the nucleus pulposus and annular fibrosus in vivo. The scaffold exhibited good biomechanical function and demonstrated the clinical application potential of dual growth factors-releasing IVD scaffold. Evaluation in large mammal animal models is necessary for further study.

BIOACTIVE MATERIALS (2021)

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Article Multidisciplinary Sciences

A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis

Bo Shen et al.

Summary: Stromal cells in adult bone marrow expressing leptin receptor are a critical source of growth factors for haematopoietic stem cells. Among these cells, those expressing osteogenic growth factor osteolectin are poised for osteogenesis, while those near sinusoids are primed for adipogenesis. Mechanical stimulation is crucial for the maintenance of the peri-arteriolar niche for osteogenesis and lymphopoiesis.

NATURE (2021)

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Review Nanoscience & Nanotechnology

Engineering organoids

Moritz Hofer et al.

Summary: This review discusses the application of engineering approaches to enhance the reproducibility and physiological relevance of organoids, including cellular engineering, designer matrices, and microfluidics.

NATURE REVIEWS MATERIALS (2021)

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Article Engineering, Biomedical

Monitoring mechanical stimulation for optimal tendon tissue engineering: A mechanical and biological multiscale study

Alejandro Garcia Garcia et al.

Summary: Mechanical stimulation can promote cell and matrix orientation, leading to tendon-like differentiation. Dynamic stimulation enhances storage modulus, showing a dominant elastic response in the cell-constructs.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Article Engineering, Biomedical

Boosting in vitro cartilage tissue engineering through the fabrication of polycaprolactone-gelatin 3D scaffolds with specific depth-dependent fiber alignments and mechanical stimulation

Angela Semitela et al.

Summary: This study utilized different depth-dependent alignments of polycaprolactone-gelatin electrospun fibers to assemble three-dimensional scaffold architectures for evaluating chondrocyte responses under various culture conditions. The results showed that the depth-dependent fiber alignments in the 3D scaffolds enhanced chondrocyte proliferation and migration towards the fibrous systems, while mechanical stimulation protocols significantly increased cell metabolic activity and extracellular matrix deposition.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2021)

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Article Engineering, Biomedical

Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration

Penghui Zhang et al.

Summary: The study demonstrated that mechanical loading can influence the inflammatory responses and osteogenic differentiation of MSCs. Biofabrication of scaffolds with mechanical loading led to downregulation of inflammatory mediators and upregulation of ALP and COL1A1. The ECM-based scaffolds biofabricated with mechanical loading before freeze-drying facilitated M2 polarization of macrophages and bone regeneration, showing promise as a strategy for bone biomaterials.

BIOACTIVE MATERIALS (2021)

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Review Engineering, Biomedical

Synthetic tissue engineering with smart, cytomimetic protocells

David William Green et al.

Summary: Synthetic protocells are engineered versions of natural cells, with potential applications in synthetic biology and tissue engineering. They have the ability to enhance biomaterials and increase cell productivity.Furthermore, synthetic proto-tissues generated by collective symbiosis show autonomous characteristics and can be used for a variety of applications such as drug delivery and renewable fuel production.

BIOMATERIALS (2021)

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Article Cell Biology

Mechanosensitive Piezo1 in endothelial cells promotes angiogenesis to support bone fracture repair

Peng Chen et al.

Summary: Piezo1, a calcium-permeable non-selective cationic channel, plays a crucial role in sensing mechanical stimulation in multicellular organisms, mediating angiogenesis and bone fracture repair processes. Deletion of endothelial Piezo1 may impair bone fracture repair, affecting various biological processes and signaling pathways.

CELL CALCIUM (2021)

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Review Chemistry, Multidisciplinary

Engineering Bioactive Scaffolds for Skin Regeneration

Motaharesadat Hosseini et al.

Summary: Large skin wounds present challenges in clinical settings, with a wide variety of skin grafts and scaffolds being used to overcome issues related to tissue repair. Progress in biomaterial science and manufacturing technologies has made the idea of biomaterial-based skin grafts with scarless wound healing and full skin organ reconstruction more achievable than ever.

SMALL (2021)

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Article Multidisciplinary Sciences

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Job O. de Jong et al.

Summary: Mutations in CNTNAP2 have been linked to a specific form of Autism Spectrum Disorder. Using forebrain organoids derived from induced pluripotent stem cells of patients with this mutation, the study found that the increased volume and cell number were driven by abnormal cellular proliferation and neurogenesis, offering insights into potential therapeutic strategies for ASD.

NATURE COMMUNICATIONS (2021)

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Review Medicine, Research & Experimental

Thoughts on cartilage tissue engineering: A 21st century perspective

Theofanis Stampoultzis et al.

Summary: Hyaline cartilage in mature individuals has poor repair capacity, leading to potential degeneration even with minor defects, impacting quality of life. Challenges remain in translating in vitro cartilage engineering strategies from lab to clinic, with a focus on biomaterial scaffolds, tissue biofabrication, and mechanobiology.

CURRENT RESEARCH IN TRANSLATIONAL MEDICINE (2021)

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Review Cell & Tissue Engineering

Cellular human tissue-engineered skin substitutes investigated for deep and difficult to heal injuries

Alvaro Sierra-Sanchez et al.

Summary: TESSs, including autologous and allogeneic substitutes, hold promise for treating significant skin injuries and dermatological pathologies. Future directions in the field involve improving animal models, incorporating diverse cell types, and developing 3D bioprinting techniques.

NPJ REGENERATIVE MEDICINE (2021)

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Review Cell & Tissue Engineering

Roles of mechanosensitive channel Piezo1/2 proteins in skeleton and other tissues

Lei Qin et al.

Summary: Mechanotransduction is a fundamental ability in living organisms that allows them to receive and respond to physical signals. Piezo proteins act as mechanically activated ion channels and play essential roles in mechanosensation and transduction in various organs and tissues. The Piezo family, especially Piezo1 and Piezo2, has been found to have predominant contributions in skeletal development and mechano-stimulated bone homeostasis.

BONE RESEARCH (2021)

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Article Materials Science, Biomaterials

The role of micro-vibration parameters in inflammatory responses of macrophages cultured on biphasic calcium phosphate ceramics and the resultant influence on osteogenic differentiation of mesenchymal stem cells

Jinjie Wu et al.

Summary: This study investigated the effects of mechanical stimulation on macrophage inflammatory response and osteogenesis in the presence of osteoinductive BCP ceramics. The findings suggest that frequency plays a dominant role in regulating macrophage inflammatory responses, with the optimal combination of MVs parameters inducing a healing-associated M2 phenotype and promoting osteogenic differentiation of BMMSCs. These insights can help optimize bone substitute materials for improved clinical performance.

JOURNAL OF MATERIALS CHEMISTRY B (2021)

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Article Medicine, Research & Experimental

Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium

Kun Lu et al.

Summary: Bio-engineered myocardium has the potential for myocardial physiology studies, but current protocols fall short of simulating postnatal myocardial growth conditions. A new approach using progressive stretch has been developed to improve the maturation of engineered heart tissue.

THERANOSTICS (2021)

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Article Cell & Tissue Engineering

Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells

Pinghui Zhou et al.

Summary: This study investigated the influence of scaffold fiber diameter and cyclic tensile strain (CTS) on rabbit AF-derived stem cells (AFSCs) differentiation. Small-diameter scaffolds led to round cell morphologies with upregulated collagen-I expression, while large-diameter scaffolds induced spindle-like cells and increased collagen-II and aggrecan expression. CTS further enhanced these effects, suggesting potential applications for engineered AF tissue regeneration.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Review Medicine, Research & Experimental

Small molecule-based treatment approaches for intervertebral disc degeneration: Current options and future directions

Amir Kamali et al.

Summary: Low back pain is a major cause of disability, with symptomatic intervertebral disc degeneration contributing to a significant portion of cases. Current treatments often fail to address the root problem, leading to a need for novel therapies. Small molecule-based therapy shows potential in treating intervertebral disc degeneration, but is still in its early stages of development.

THERANOSTICS (2021)

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Article Physiology

The Osteocyte: New Insights

Alexander G. Robling et al.

Annual Review of Physiology (2020)

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Article Medicine, Research & Experimental

Salidroside enhances proliferation and maintains phenotype of articular chondrocytes for autologous chondrocyte implantation (ACI) via TGF-β/Smad3 Signal

Miao Sun et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemical Research Methods

Tumor organoid-T-cell coculture systems

Chiara M. Cattaneo et al.

NATURE PROTOCOLS (2020)

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Article Genetics & Heredity

Extracellular Vesicles Derived from Human Gingival Mesenchymal Stem Cells: A Transcriptomic Analysis

Serena Silvestro et al.

GENES (2020)

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Article Biology

Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-satenin

Taifeng Zhou et al.

ELIFE (2020)

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Review Nanoscience & Nanotechnology

Materials design for bone-tissue engineering

Gerry L. Koons et al.

NATURE REVIEWS MATERIALS (2020)

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Article Multidisciplinary Sciences

Enhanced Chondrogenic Capacity of Mesenchymal Stem Cells After TNFα Pre-treatment

Chantal Voskamp et al.

Frontiers in Bioengineering and Biotechnology (2020)

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Article Cell Biology

Mechanical force modulates periodontal ligament stem cell characteristics during bone remodelling via TRPV4

Shan-Shan Jin et al.

CELL PROLIFERATION (2020)

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Review Cell Biology

Human organoids: model systems for human biology and medicine

Jihoon Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

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Article Biophysics

Role of biomechanics in vascularization of tissue-engineered bones

Fatemeh Mokhtari-Jafari et al.

JOURNAL OF BIOMECHANICS (2020)

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Article Multidisciplinary Sciences

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Mikhail Nikolaev et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Phenotypic landscape of intestinal organoid regeneration

Ilya Lukonin et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Network-based machine learning in colorectal and bladder organoid models predicts anti-cancer drug efficacy in patients

JungHo Kong et al.

NATURE COMMUNICATIONS (2020)

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Article Engineering, Biomedical

Shear stress induced by fluid flow produces improvements in tissue-engineered cartilage

E. Y. Salinas et al.

BIOFABRICATION (2020)

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Editorial Material Cell & Tissue Engineering

Chasing the Paradigm: Clinical Translation of 25 Years of Tissue Engineering

Tyler Hoffman et al.

TISSUE ENGINEERING PART A (2019)

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Article Genetics & Heredity

Development of an efficient perfusion-based protocol for whole-organ decellularization of the ovine uterus as a human-sized model and in vivo application of the bioscaffolds

Seyedeh Sima Daryabari et al.

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS (2019)

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Article Biochemistry & Molecular Biology

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Oded Kopper et al.

NATURE MEDICINE (2019)

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Article Materials Science, Biomaterials

Mechanical and Biochemical Stimulation of 3D Multilayered Scaffolds for Tendon Tissue Engineering

Chiara Rinoldi et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Engineering, Biomedical

A viscoelastic adhesive epicardial patch for treating myocardial infarction

Xiao Lin et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Editorial Material Engineering, Biomedical

An optimal gel patch for the injured heart

Dawn Bannerman et al.

NATURE BIOMEDICAL ENGINEERING (2019)

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Article Cell Biology

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration

Luigi Aloia et al.

NATURE CELL BIOLOGY (2019)

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Review Cell Biology

How is mechanobiology involved in mesenchymal stem cell differentiation toward the osteoblastic or adipogenic fate?

Dafna Benayahu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Cell & Tissue Engineering

Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets

Shinpei Tsuruyama et al.

REGENERATIVE THERAPY (2019)

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Review Engineering, Biomedical

Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair

Biranche Tandon et al.

ACTA BIOMATERIALIA (2018)

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Article Biotechnology & Applied Microbiology

Segmental bone replacement via patient-specific, three-dimensional printed bioresorbable graft substitutes and their use as templates for the culture of mesenchymal stem cells under mechanical stimulation at various frequencies

Rebecca Chung et al.

BIOTECHNOLOGY AND BIOENGINEERING (2018)

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Article Multidisciplinary Sciences

Electrical Stimulation with a Conductive Polymer Promotes Neurite Outgrowth and Synaptogenesis in Primary Cortical Neurons in 3D

Qingsheng Zhang et al.

SCIENTIFIC REPORTS (2018)

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Review Biochemistry & Molecular Biology

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

Ekaterina V. Medvedeva et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Genetics & Heredity

Progress and potential in organoid research

Giuliana Rossi et al.

NATURE REVIEWS GENETICS (2018)

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Article Multidisciplinary Sciences

Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids

Kwang Bo Jung et al.

NATURE COMMUNICATIONS (2018)

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Review Chemistry, Physical

Biomaterials and engineered microenvironments to control YAP/TAZ-dependent cell behaviour

Giovanna Brusatin et al.

NATURE MATERIALS (2018)

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Review Cell & Tissue Engineering

Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts

Yujiao Han et al.

BONE RESEARCH (2018)

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Review Cell & Tissue Engineering

Biomimetic delivery of signals for bone tissue engineering

Ming Dang et al.

BONE RESEARCH (2018)

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Article Engineering, Biomedical

Preconditioning of mesenchymal stromal cells toward nucleus pulposus-like cells by microcryogels-based 3D cell culture and syringe-based pressure loading system

Yang Zeng et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2017)

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Article Reproductive Biology

De- and recellularization of the pig uterus: a bioengineering pilot study

Hannes Campo et al.

BIOLOGY OF REPRODUCTION (2017)

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Article Neurosciences

mTOR regulates peripheral nerve response to tensile strain

James M. Love et al.

JOURNAL OF NEUROPHYSIOLOGY (2017)

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Article Engineering, Biomedical

Short bursts of cyclic mechanical compression modulate tissue formation in a 3D hybrid scaffold

M. Brunelli et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2017)

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Review Hematology

Microfluidic traction force microscopy to study mechanotransduction in angiogenesis

Luke Boldock et al.

MICROCIRCULATION (2017)

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Article Biotechnology & Applied Microbiology

Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells

Karl R. Koehler et al.

NATURE BIOTECHNOLOGY (2017)

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Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

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Article Multidisciplinary Sciences

In vivo engineering of bone tissues with hematopoietic functions and mixed chimerism

Yu-Ru Shih et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Functional compressive mechanics and tissue biocompatibility of an injectable SF/PU hydrogel for nucleus pulposus replacement

Jingen Hu et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Injectable and thermosensitive TGF-β1-loaded PCEC hydrogel system for in vivo cartilage repair

Tengfei Zhou et al.

SCIENTIFIC REPORTS (2017)

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Review Biotechnology & Applied Microbiology

It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration

Andrea Grosso et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2017)

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Article Engineering, Biomedical

Living nanofiber yarn-based woven biotextiles for tendon tissue engineering using cell tri-culture and mechanical stimulation

Shaohua Wu et al.

ACTA BIOMATERIALIA (2017)

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Article Medicine, Research & Experimental

TRPV4 functions in flow shear stress induced early osteogenic differentiation of human bone marrow mesenchymal stem cells

Kongzu Hu et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Review Engineering, Biomedical

Biomaterials-based in situ tissue engineering

Mark H. Murdock et al.

CURRENT OPINION IN BIOMEDICAL ENGINEERING (2017)

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Article Orthopedics

Impact of cyclic mechanical stimulation on the expression of extracellular matrix proteins in human primary rotator cuff fibroblasts

Birgit Lohberger et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2016)

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Article Engineering, Biomedical

Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering

T. N. Vo et al.

BIOMATERIALS (2016)

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Article Engineering, Biomedical

Bio-inspired in situ crosslinking and mineralization of electrospun collagen scaffolds for bone tissue engineering

Chetna Dhand et al.

BIOMATERIALS (2016)

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Article Medicine, General & Internal

Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in Ex vivo Organ Culture

Li-Guo Zhu et al.

CHINESE MEDICAL JOURNAL (2016)

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Article Cell Biology

Tenogenesis of bone marrow-, adipose-, and tendon-derived stem cells in a dynamic bioreactor

Daniel W. Youngstrom et al.

CONNECTIVE TISSUE RESEARCH (2016)

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Article Biotechnology & Applied Microbiology

Effect of Static Load on the Nucleus Pulposus of Rabbit Intervertebral Disc Motion Segment in an Organ Culture

Jia-Wen Zhan et al.

BIOMED RESEARCH INTERNATIONAL (2016)

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Article Neurosciences

Electrical Stimulation of the Retina to Produce Artificial Vision

James D. Weiland et al.

ANNUAL REVIEW OF VISION SCIENCE, VOL 2 (2016)

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Article Orthopedics

Mechanical stimulation enhances integration in an in vitro model of cartilage repair

John S. Theodoropoulos et al.

KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY (2016)

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Article Engineering, Biomedical

Injectable osteogenic and angiogenic nanocomposite hydrogels for irregular bone defects

M. Vishnu Priya et al.

BIOMEDICAL MATERIALS (2016)

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Article Cell & Tissue Engineering

HUMAN PERIODONTAL LIGAMENT STEM CELLS CULTURED ONTO CORTICO-CANCELLOUS SCAFFOLD DRIVE BONE REGENERATIVE PROCESS

F. Diomede et al.

EUROPEAN CELLS & MATERIALS (2016)

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Review Engineering, Biomedical

Piezoelectric materials for tissue regeneration: A review

Amir Hossein Rajabi et al.

ACTA BIOMATERIALIA (2015)

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Article Biophysics

Cooperative Effects of Matrix Stiffness and Fluid Shear Stress on Endothelial Cell Behavior

Julie C. Kohn et al.

BIOPHYSICAL JOURNAL (2015)

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Article Orthopedics

A Bioreactor System for In Vitro Tendon Differentiation and Tendon Tissue Engineering

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Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

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The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids

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Dynamic compression and co-culture with nucleus pulposus cells promotes proliferation and differentiation of adipose-derived mesenchymal stem cells

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Single luminal epithelial progenitors can generate prostate organoids in culture

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Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

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Generation of cerebral organoids from human pluripotent stem cells

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Fluid shear stress threshold regulates angiogenic sprouting

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Intervertebral disc and stem cells cocultured in biomimetic extracellular matrix stimulated by cyclic compression in perfusion bioreactor

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SPINE JOURNAL (2014)

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Programmable mechanical stimulation influences tendon homeostasis in a bioreactor system

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DRUG DISCOVERY TODAY (2013)

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Neural responses to electrical stimulation on patterned silk films

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Cerebral organoids model human brain development and microcephaly

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Uniaxial mechanical tension promoted osteogenic differentiation of rat tendon-derived stem cells (rTDSCs) via the Wnt5a-RhoA pathway

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Preferential cell response to anisotropic electro-spun fibrous scaffolds under tension-free conditions

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Electrical signaling in control of ocular cell behaviors

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PROGRESS IN RETINAL AND EYE RESEARCH (2012)

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Contribution of Proteoglycan Osmotic Swelling Pressure to the Compressive Properties of Articular Cartilage

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Slow Stretching That Mimics Embryonic Growth Rate Stimulates Structural and Mechanical Development of Tendon-Like Tissue In Vitro

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Review Engineering, Biomedical

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Mechanical Loading Increased BMP-2 Expression which Promoted Osteogenic Differentiation of Tendon-Derived Stem Cells

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Mechanical Influences on Morphogenesis of the Knee Joint Revealed through Morphological, Molecular and Computational Analysis of Immobilised Embryos

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Effects of Radial Compression on a Novel Simulated Intervertebral Disc-Like Assembly Using Bone Marrow-Derived Mesenchymal Stem Cell Cell-Sheets for Annulus Fibrosus Regeneration

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Biomechanics in bone tissue engineering

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COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING (2010)

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Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-β pathway

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Effects of mechanical stimulation by a powered toothbrush on the healing of periodontal tissue in a rat model of periodontal disease

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Mechanical loading regimes affect the anabolic and catabolic activities by chondrocytes encapsulated in PEG hydrogels

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OSTEOARTHRITIS AND CARTILAGE (2010)

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Improving Chondrogenesis: Potential and Limitations of SOX9 Gene Transfer and Mechanical Stimulation for Cartilage Tissue Engineering

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TISSUE ENGINEERING PART A (2010)

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The differential effect of scaffold composition and architecture on chondrocyte response to mechanical stimulation

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BIOMATERIALS (2009)

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A scaffold-bioreactor system for a tissue-engineered trachea

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Neuroprotective effect of transcorneal electrical stimulation on light-induced photoreceptor degeneration

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Mechanical Stimulation Alters Tissue Differentiation and Molecular Expression during Bone Healing

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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NATURE (2009)

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Metal and postnatal bone development: reviewing the role of mechanical stimuli and nutrition

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Induction of fibroblast growth factor-2 by electrical stimulation in cultured retinal Mueller cells

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Dynamic compression effects on intervertebral disc mechanics and biology

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SPINE (2008)

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Intra-scaffold continuous medium flow combines chondrocyte seeding and culture systems for tissue engineered trachea construction

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Interactive Cardiovascular and Thoracic Surgery (2008)

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Hydrostatic pressure differentially regulates outer and inner annulus fibrosus cell matrix production in 3D scaffolds

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ANNALS OF BIOMEDICAL ENGINEERING (2008)

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Effects of electrical stimulation at different frequencies on regeneration of transected peripheral nerve

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NEUROREHABILITATION AND NEURAL REPAIR (2008)

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Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure

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Biologic response of the intervertebral disc to static and dynamic compression in vitro

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SPINE (2007)

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Mechanical stimulation increases collagen type I and collagen 1219 type III gene expression of stem cell-collagen sponge constructs for patellar tendon repair

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TISSUE ENGINEERING (2007)

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Article Biophysics

Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading

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BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2007)

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Clinical experience using cultured epithelial autografts leads to an alternative methodology for transferring skin cells from the laboratory to the patient

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REGENERATIVE MEDICINE (2006)

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Article Cell & Tissue Engineering

Effects of mechanical stimulation on the biomechanics and histology of stem cell-collagen sponge constructs for rabbit patellar tendon repair

Natalia Juncosa-Melvin et al.

TISSUE ENGINEERING (2006)

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Rat spinal motion segment in organ culture: A cell viability study

Tae-Hong Lim et al.

SPINE (2006)

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Design of a high-resolution optoelectronic retinal prosthesis

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Autologous chondrocyte implantation - Culture in a TGF-beta-containing medium enhances the reexpression of a chondrocytic phenotype in passaged human chondrocytes in pellet culture

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JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME (2005)

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Changes in nuclear composition following cyclic compression of the intervertebral disc in an in vivo rat-tail model

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MEDICAL ENGINEERING & PHYSICS (2004)

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Cyclic tensile stretch modulates proteoglycan production by intervertebral disc annulus fibrosus cells through production of nitrite oxide

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JOURNAL OF CELLULAR BIOCHEMISTRY (2003)

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Long-term intermittent shear deformation improves the quality of cartilaginous tissue formed in vitro

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JOURNAL OF ORTHOPAEDIC RESEARCH (2003)

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A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee

G Bentley et al.

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME (2003)

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Compressive properties and function-composition relationships of developing bovine articular cartilage

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Stem cells in tissue engineering

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NATURE (2001)

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The developing bone: Slave or master of its cells and molecules?

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PEDIATRIC RESEARCH (2001)

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Effect of compressive loading on chondrocyte differentiation in agarose cultures of chick limb-bud cells

SH Elder et al.

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