Derivation and Use of Cell Lines from Mouse Models of Melanoma

The establishment of consistent genetically modified mouse melanoma models and cell lines is of paramount importance for prevention and treatment. In this study, we review the different mouse melanoma cell lines that have been established. After careful molecular characterization of the established mouse melanoma cell lines, modification of the genome, microenvironment, or even the environment using appropriate in cellulo and in vivo assays may reveal novel genetic and nongenetic changes. These murine melanoma cell lines with defined genetic mutations allow the testing of innovative therapies based on chemistry, physics, and biology using alternative methods. In addition to the fundamental aspects, these results are important for humans because of the relevance of these murine melanoma cell lines to human disease.

Automated summary

The establishment of consistent genetically modified mouse melanoma models and cell lines is crucial for prevention and treatment. This study reviews different mouse melanoma cell lines and explores the changes they undergo through molecular characterization and modification of the genome and microenvironment. These cell lines with defined genetic mutations enable the testing of innovative therapies and have relevance to human disease.