4.7 Article

Potential Anti-Mpox Virus Activity of Atovaquone, Mefloquine, and Molnupiravir, and Their Potential Use as Treatments

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Infectious Diseases

Clinical features and management of human monkeypox: a retrospective observational study in the UK

Hugh Adler et al.

Summary: This study retrospectively observed the clinical course of monkeypox in seven patients in the UK from 2018 to 2021. The study found that prolonged PCR positivity led to isolation of five patients for more than 3 weeks. Three patients treated with brincidofovir developed elevated liver enzymes, leading to termination of the therapy. One patient treated with tecovirimat experienced no adverse effects and had a shorter duration of viral shedding and illness compared to the other six patients.

LANCET INFECTIOUS DISEASES (2022)

News Item Multidisciplinary Sciences

MONKEYPOX GOES GLOBAL: WHY SCIENTISTS ARE ON ALERT

Max Kozlov

NATURE (2022)

Review Virology

A Broad Antiviral Strategy: Inhibitors of Human DHODH Pave the Way for Host-Targeting Antivirals against Emerging and Re-Emerging Viruses

Yucheng Zheng et al.

Summary: Rapid development of broad-spectrum antiviral therapies is urgently needed for emerging and re-emerging viruses. Host-targeting antivirals that target universal host factors necessary for viral replication, such as dihydroorotate dehydrogenase (DHODH), show promise in inhibiting viral infection. DHODH inhibitors have demonstrated potential in inhibiting viral replication and suppressing cytokine storms.

VIRUSES-BASEL (2022)

Article Medicine, General & Internal

Monkeypox Virus Infection in Humans across 16 Countries - April-June 2022

John P. Thornhill et al.

Summary: This report describes 528 cases of monkeypox in 16 countries. Common clinical findings include rash, mucosal lesions, fever, lethargy, and lymphadenopathy. Few patients required hospitalization.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Review Microbiology

Animal Models Used in Monkeypox Research

Marianna Doman et al.

Summary: Monkeypox is an emerging zoonotic disease that poses a significant threat to public health. Despite limited knowledge about its natural reservoirs and disease management, experimental investigations have provided valuable information on pathogenesis, virulence factors, and transmission of the virus, aiding in the development of prevention measures and effective vaccines.

MICROORGANISMS (2022)

Article Pharmacology & Pharmacy

Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2

Hirofumi Ohashi et al.

Summary: The study quantified the intrinsic sensitivity of SARS-CoV-2 Omicron subvariants BA.2 and BA.1 to neutralizing antibodies and antiviral drugs compared with other variants. Results showed diverse sensitivities of these variants to antibodies and differences in drug responses.

ANTIVIRAL RESEARCH (2022)

Article Biochemistry & Molecular Biology

The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2?

David A. Jans et al.

Summary: Ivermectin, originally approved for parasitic indications, has gained attention in recent years as a potential antiviral agent. Studies have shown its ability to inhibit a range of viruses, including HIV-1, dengue, Zika, and SARS-CoV-2. Numerous clinical trials are currently underway, with preliminary results indicating clinical benefits.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

Article Microbiology

Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2

Wendy P. Painter et al.

Summary: Molnupiravir showed rapid appearance and dose-proportional increase in plasma, with good tolerability in healthy volunteers. The study evaluated single and multiple doses of molnupiravir and the impact of food on pharmacokinetics in subjects, showing no accumulation following multiple doses and a decrease in absorption rate when administered with food, but no decrease in overall exposure.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Article Biochemistry & Molecular Biology

A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS-CoV-2

Kwang Su Kim et al.

Summary: The study compared the viral dynamics of SARS-CoV-2 with MERS-CoV and SARS-CoV, finding that SARS-CoV-2 had a higher within-host reproduction number and a shorter time to viral load peak. Therapies targeting de novo infection or virus production were found to be effective if initiated before the viral load peak, while therapies promoting cytotoxicity of infected cells were less sensitive to treatment timing. Combining both types of therapies showed synergistic effects in reducing viral load.

PLOS BIOLOGY (2021)

Article Microbiology

Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro

Kaho Shionoya et al.

Summary: Mefloquine, an anti-malarial drug, demonstrated higher anti-SARS-CoV-2 activity than Hydroxychloroquine, inhibiting viral entry to target cells and showing synergistic antiviral activity when combined with other drugs. Mathematical modeling predicted that standard dosage of Mefloquine could reduce viral load and shorten the time until virus elimination in patients.

FRONTIERS IN MICROBIOLOGY (2021)

Article Multidisciplinary Sciences

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment

Hirofumi Ohashi et al.

Summary: The study identified cepharanthine and nelfinavir as potential antiviral agents against SARS-CoV-2, with different modes of action. A synergistic effect was observed when these two drugs were used in combination, shortening the time until viral clearance. Further evaluation of the anti-SARS-CoV-2 activity of cepharanthine and nelfinavir is warranted.

ISCIENCE (2021)

Article Biochemistry & Molecular Biology

Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis

Florian Kabinger et al.

Summary: Molnupiravir is an oral antiviral drug candidate that increases viral RNA mutations frequency and inhibits replication of SARS-CoV-2 by altering the substrate preference of RdRp. This two-step mutagenesis mechanism can explain the broad-spectrum antiviral activity of molnupiravir, making it a promising COVID-19 treatment option.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2021)

Article Medicine, General & Internal

Detection of significant antiviral drug effects on COVID-19 with reasonable sample sizes in randomized controlled trials: A modeling study

Shoya Iwanami et al.

Summary: The study highlighted the importance of designing clinical trials for antiviral drugs for COVID-19, emphasizing the need for early recruitment of patients to reduce sample sizes and observe statistically significant results. It also pointed out the potential bias in observational studies due to heterogeneity in viral dynamics, and the importance of more precise models for reliable sample size estimates.

PLOS MEDICINE (2021)

Review Microbiology

Drug Development against Smallpox: Present and Future

Deborah Delaune et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2020)

Article Medicine, General & Internal

Oral Tecovirimat for the Treatment of Smallpox

Douglas W. Grosenbach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Multidisciplinary Sciences

Enigmatic origin of the poxvirus membrane from the endoplasmic reticulum shown by 3D imaging of vaccinia virus assembly mutants

Andrea S. Weisberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection

Yoshiki Koizumi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Pharmacology & Pharmacy

Synergistic drug combination effectively blocks Ebola virus infection

Wei Sun et al.

ANTIVIRAL RESEARCH (2017)

Article Microbiology

Characterization of β-D-N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus

Maryam Ehteshami et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2017)

Article Multidisciplinary Sciences

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren et al.

NATURE (2016)

Article Infectious Diseases

ST-246 is a key antiviral to inhibit the viral F13L phospholipase, one of the essential proteins for orthopoxvirus wrapping

Sophie Duraffour et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2015)

Review Mathematical & Computational Biology

Mathematical modeling of multi-drugs therapy: a challenge for determining the optimal combinations of antiviral drugs

Yoshiki Koizumi et al.

THEORETICAL BIOLOGY AND MEDICAL MODELLING (2014)

Article Infectious Diseases

Antiviral activity of nucleoside analogues against norovirus

Veronica P. Costantini et al.

ANTIVIRAL THERAPY (2012)

Article Infectious Diseases

Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture

Laila Castro Schnellrath et al.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2011)

Article Biotechnology & Applied Microbiology

Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates

Masayuki Saijo et al.

JOURNAL OF GENERAL VIROLOGY (2009)

Review Medicine, General & Internal

Drugs for preventing malaria in travellers

Frederique A. Jacquerioz et al.

COCHRANE DATABASE OF SYSTEMATIC REVIEWS (2009)

Article Biochemistry & Molecular Biology

Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs

Lin Shen et al.

NATURE MEDICINE (2008)

Review Cell Biology

Cytoplasmic organization of POXvirus DNA replication

B Schramm et al.

TRAFFIC (2005)

Article Microbiology

Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture

LJ Stuyver et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2003)