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Article
Infectious Diseases
Lamprini Veneti et al.
Summary: A study found that the Omicron variant of COVID-19 has a 73% reduced risk of hospitalization compared to the Delta variant. Omicron cases who had received two doses of the vaccine 7-179 days before diagnosis had a lower risk compared to Delta (66% vs 93%), while those who received three doses had a similar risk reduction (86% vs 88%).
Article
Infectious Diseases
Lamprini Veneti et al.
Summary: There was no difference in the risk of hospitalization between Delta variant cases and Alpha variant cases in Norway. Partially vaccinated and fully vaccinated cases had a lower risk of hospitalization compared to unvaccinated cases.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Nicole Wolter et al.
Summary: According to data analysis from South Africa, individuals infected with the omicron variant have a lower likelihood of hospitalization compared to those infected with non-omicron variants. Furthermore, individuals infected with the omicron variant have a lower odds of severe disease compared to individuals infected with the earlier delta variant.
Article
Medicine, General & Internal
Luke B. Snell et al.
Summary: This study investigates the association between the Alpha variant of SARS-CoV-2 and disease severity, finding that the Alpha variant is associated with increased severity. The number of nosocomial cases remained similar in both waves, despite the implementation of infection control interventions before the second wave.
Article
Immunology
Daniel J. Grint et al.
Summary: The study found that the SARS-CoV-2 alpha variant is more transmissible and associated with increased rates of hospitalization and mortality compared to the wild-type virus in England between November 16, 2020 and January 11, 2021.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Sean Wei Xiang Ong et al.
Summary: The study revealed an association between infection with the B.1.617.2 variant and increased disease severity, higher viral loads, and prolonged duration of viral shedding. Vaccination remained protective against severe outcomes.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Katherine A. Twohig et al.
Summary: A study in England found that patients with COVID-19 infected with the delta variant were more likely to be admitted to hospital or attend emergency care compared to those infected with the alpha variant. This suggests that outbreaks of the delta variant in unvaccinated populations may pose a greater burden on healthcare services.
LANCET INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Tommy Nyberg et al.
Summary: The Omicron variant shows lower severity compared to Delta, especially in terms of hospital admission and death, with significant variations by age. Unvaccinated cases experience a larger reduction in intrinsic severity, while vaccinated cases experience reduced vaccine effectiveness. Booster vaccination with mRNA vaccines provides over 70% protection against hospitalization and death in breakthrough Omicron infections.
Article
Infectious Diseases
Peter Bager et al.
Summary: This study aimed to estimate the risk of hospitalization after infection with the SARS-CoV-2 omicron variant compared with the delta variant in Denmark. The results showed that vaccination was associated with a lower risk of hospitalization, and Omicron infection was associated with a lower risk of hospitalization compared to Delta infection.
LANCET INFECTIOUS DISEASES
(2022)
Article
Virology
Celia Sentis et al.
Summary: This study found that the RT-PCR Ct values of Omicron cases were significantly higher than Delta cases when sampled within 5 days of symptom onset, indicating that the spread of the Omicron variant is indeed related to higher viral loads.
Article
Multidisciplinary Sciences
John T. McCrone et al.
Summary: The globally spread SARS-CoV-2 Delta variant of concern has caused resurgences of COVID-19 worldwide. In England, the Delta variant was introduced through travel and social restrictions relaxation and spread through increased human activity. Hotel quarantine for travelers helped reduce importation transmission, but the Delta transmission chains were already established before travel restrictions were implemented. Increased inter-regional travel and local population mixing were key factors in the nationwide dissemination of Delta.
Article
Biochemistry & Molecular Biology
Joseph A. Lewnard et al.
Summary: Comparison of outcomes of SARS-CoV-2 Delta and Omicron infections reveals reduced severity of Omicron infections, especially in unvaccinated individuals. There is no differential risk of severe outcomes between subvariants BA.1 and BA.2. Continual assessment of clinical outcomes associated with SARS-CoV-2 variants is crucial for medical interventions and healthcare resource management.
Article
Health Care Sciences & Services
Shaun R. Seaman et al.
Summary: When comparing the risk of a post-infection binary outcome between two variants of an infectious pathogen, it is crucial to adjust for the calendar time of infection. This study demonstrates that if the time from infection to positive test is correlated with the outcome, the risk ratio adjusted for positive test time can vary significantly from the risk ratio adjusted for infection time.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2022)
Article
Microbiology
Brian J. Willett et al.
Summary: Vaccines based on the spike protein of SARS-CoV-2 are vital in combating COVID-19, but the emergence of the Omicron variant poses a threat to this strategy. Studies have shown that the Omicron variant evades neutralization by sera from individuals vaccinated with different vaccines and reduces real-world vaccine effectiveness, although booster vaccination can partially restore its effectiveness. Additionally, the Omicron variant exhibits distinct cell entry pathways and phenotypes, which may contribute to its rapid global spread and altered pathogenicity.
NATURE MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Michel Tassetto et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2022)
Article
Respiratory System
Oliver Stirrup et al.
Summary: The study found that the B.1.1.7 lineage did not show a significant increase in overall mortality or ITU admission compared to other lineages. However, females infected with this variant may be at an increased risk of admission to intensive care and at a modestly increased risk of mortality.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Article
Medicine, General & Internal
David N. Fisman et al.
Summary: Research in Ontario, Canada, showed that new variants of concern (VOCs) of SARS-CoV-2 have higher risks of hospitalization, ICU admission, and death compared to non-VOC strains, with the Delta variant showing the most pronounced increase in risk.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2021)
Article
Medicine, General & Internal
D. M. Weinreich et al.
Summary: Recent data indicate that complications and death from Covid-19 may be related to high viral loads. In this trial involving nonhospitalized patients, a cocktail of two neutralizing monoclonal antibodies (REGN-COV2) reduced viral load, with a greater effect in patients with no immune response or high viral load at baseline. Safety outcomes were similar between REGN-COV2 dose groups and the placebo group.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Infectious Diseases
Elizabeth Bast et al.
LANCET INFECTIOUS DISEASES
(2021)
Letter
Infectious Diseases
Peter Bager et al.
LANCET INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Lamprini Veneti et al.
Summary: This study in Norway found that the B.1.1.7 and B.1.351 variants of concern were associated with an increased risk of hospitalisation and admission to ICU compared to non-VOC. The findings underscore the importance of prevention, vaccination, and hospital surge capacity planning in combating the spread of these variants.
Article
Medicine, General & Internal
Robert Challen et al.
Summary: The study found that the mortality hazard ratio associated with infection with VOC-202012/1 compared with previously circulating variants was 1.64, indicating an increase in deaths from 2.5 to 4.1 per 1000 detected cases in comparatively low risk group of covid-19 patients in the community. This suggests that infection with VOC-202012/1 may lead to substantial additional mortality compared with previously circulating variants, impacting healthcare capacity planning and control policies.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Michelle Sholzberg et al.
Summary: This study aimed to evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. The results of the study may help guide the treatment options for similar patients in the future.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Infectious Diseases
Daniel J. Grint et al.
Summary: The SARS-CoV-2 B.1.1.7 VOC is spreading across Europe and poses a higher risk of death compared to non-VOC cases, with increased mortality in older individuals and those with comorbidities. This variant has the potential to spread faster and cause higher mortality than previous strains.
Article
Infectious Diseases
Dan Frampton et al.
Summary: This study describes the emergence of the B.1.1.7 variant of concern, its virological characteristics, and clinical severity in patients. Increased viral load was found in B.1.1.7 infection, but no association with severe disease was identified in the hospitalized cohort.
LANCET INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Nicholas G. Davies et al.
Summary: Studies have shown that the SARS-CoV-2 B.1.1.7 lineage is more transmissible and may cause more severe illness compared to pre-existing variants.
Letter
Medicine, General & Internal
Aziz Sheikh et al.
Review
Biology
Elisa Visher et al.
Summary: The review synthesizes evolutionary theory on infectious diseases, discussing the selection on transmission rates and virulence of zoonotic pathogens. The authors propose a three T framework of trade-offs, transmission, and time scales to understand selection during the emergence of zoonotic diseases. Virulence and transmission rate may trade-off, with selection favoring transmission rate early in the epidemic, and the optimal virulence and transmission rates can shift with the time scale of the epidemic.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Tommy Nyberg et al.
Summary: The study evaluated the relationship between Covid-19 diagnosis and the B.1.1.7 variant of concern, finding a higher risk of hospital admission for individuals infected with the B.1.1.7 variant compared to wild-type SARS-CoV-2. This increased risk of severity may be specific to adults older than 30 years.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Psychology
Paul-Christian Buerkner et al.
ADVANCES IN METHODS AND PRACTICES IN PSYCHOLOGICAL SCIENCE
(2019)
Article
Computer Science, Interdisciplinary Applications
Paul-Christian Buerkner
JOURNAL OF STATISTICAL SOFTWARE
(2017)
