4.6 Article

C-Reactive Protein: The Most Familiar Stranger

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

Monomeric C-reactive protein level is associated with osteoarthritis

Yulin Liang et al.

Summary: This study confirmed the association between plasma mCRP levels and osteoarthritis, suggesting that it can serve as an indicator to assess disease severity and monitor the effectiveness of osteoarthritis therapy.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Editorial Material Gastroenterology & Hepatology

C-Reactive Protein, a Promising Approach for Acetaminophen Hepatotoxicity

Carmen Garcia-Ruiz et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Review Immunology

Monomeric C-Reactive Protein: Current Perspectives for Utilization and Inclusion as a Prognostic Indicator and Therapeutic Target

Mark Slevin et al.

Summary: Monomeric C-reactive protein (mCRP) plays a critical role in the development of diseases caused by inflammation. Its tissue and cellular distribution are associated with inflammation and the progression of neurological and cardiovascular complications. Current research has also identified the diagnostic and prognostic potential of mCRP, making it a potential target for future therapeutic interventions.

FRONTIERS IN IMMUNOLOGY (2022)

Article Gastroenterology & Hepatology

C-Reactive Protein Protects Against Acetaminophen-Induced Liver Injury by Preventing Complement Overactivation

Hai-Yun Li et al.

Summary: This study identifies CRP as a crucial factor in acetaminophen-induced liver injury, limiting the destructive activation of complement and suppressing inflammation. CRP treatment shows a longer therapeutic time window and effectively alleviates liver injury compared to traditional treatment methods.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Biology

Secretory quality control constrains functional selection-associated protein structure innovation

Bin Cheng et al.

Summary: Biophysical models suggest that structural constraints play a dominant role in protein evolution. These constraints are closely linked to protein expression levels and together with structure-associated activities determine the in vivo functions of proteins. It has been found that despite significant differences in the levels of C-reactive protein (CRP) in different species, the in vivo functions of CRP remain conserved.

COMMUNICATIONS BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein

Ming-Yu Wang et al.

Summary: In this study, a constitutively active enhancer E1 located 37.7 kb upstream of the promoter of human CRP in hepatocytes was identified. E1 was found to be enriched in binding sites for transcription factors STAT3 and C/EBP-ss and essential for the full induction of human CRP during the acute phase. Furthermore, E1 was shown to orchestrate with the promoter of CRP to determine its varied expression across tissues and species through surveying activities of E1-promoter hybrids and the associated epigenetic modifications.

JOURNAL OF BIOLOGICAL CHEMISTRY (2022)

Review Pharmacology & Pharmacy

Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases

J. Zeller et al.

Summary: C-reactive protein (CRP) is not only a marker of inflammation and predictor of cardiovascular risk, but also a direct pathogenic pro-inflammatory mediator in atherosclerosis and cardiovascular diseases. The different conformations of the CRP system can aggravate tissue injury in pathological conditions, and studying the structural changes of CRP could be a novel therapeutic target for cardiovascular diseases and excessive inflammation.

PHARMACOLOGY & THERAPEUTICS (2022)

Article Immunology

mCRP as a Biomarker of Adult-Onset Still's Disease: Quantification of mCRP by ELISA

Chitose Fujita et al.

Summary: Plasma levels of mCRP are elevated in some autoimmune diseases, particularly AOSD. mCRP may serve as a potentially useful biomarker for AOSD, as it is significantly higher in AOSD patients compared to RA, PMR patients, and control subjects.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cardiac & Cardiovascular Systems

The monomeric C-reactive protein level is associated with the increase in carotid plaque number in patients with subclinical carotid atherosclerosis

Ivan Melnikov et al.

Summary: This study developed an assay to measure the level of mCRP in blood plasma and investigated its association with carotid atherosclerosis progression. The results revealed that higher mCRP levels were associated with an increased risk of carotid atherosclerotic plaque formation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

Article Immunology

Deficiency of C-reactive protein or human C-reactive protein transgenic treatment aggravates influenza A infection in mice

Zhuohan Zhang et al.

Summary: This study aimed to investigate the role of C-reactive protein (CRP) in influenza infection. The results showed that deficiency of CRP or human CRP transgenic treatment aggravated influenza virus infection in mice. Additionally, IL-17 and immune checkpoint may be involved in this process.

FRONTIERS IN IMMUNOLOGY (2022)

Review Immunology

C-reactive protein, immunothrombosis and venous thromboembolism

Caroline Dix et al.

Summary: C-reactive protein (CRP) is not only a marker of inflammation, but also possesses pro-inflammatory and pro-thrombotic properties. Recent studies have shown that CRP can influence the pathogenesis of atherothrombosis and venous thromboembolism (VTE), particularly in diseases and conditions associated with inflammation. Although the clinical data regarding the utility of CRP in predicting VTE are limited and conflicting, it shows clinical value in predicting recurrence, cancer-associated thrombosis, and COVID-19 in certain subsets. Further research is needed to uncover the direct role of CRP in the pathogenesis of VTE and its potential value in targeting thromboinflammation for prevention and treatment.

FRONTIERS IN IMMUNOLOGY (2022)

Article Rheumatology

Associations of C-reactive protein isoforms with systemic lupus erythematosus phenotypes and disease activity

Jesper Karlsson et al.

Summary: This study aimed to investigate the potential relationship between pentameric CRP (pCRP) and monomeric CRP (mCRP) with disease activity and clinical features of systemic lupus erythematosus (SLE). The study found that levels of pCRP and mCRP were significantly lower in SLE than antineutrophil cytoplasmic antibody-associated vasculitis (AAV) and the mCRP/pCRP ratio was higher in SLE compared to AAV. The mCRP/pCRP ratio could separate between active/quiescent disease in paired samples from SLE patients and correlated with SLICC/ACR damage index and malar rash.

ARTHRITIS RESEARCH & THERAPY (2022)

Article Immunology

Structurally Altered, Not Wild-Type, Pentameric C-Reactive Protein Inhibits Formation of Amyloid-beta Fibrils

Donald N. Ngwa et al.

Summary: In this study, it was found that immobilized proteins express an A beta epitope and A beta is a ligand for structurally altered pentameric CRP. The interaction between CRP mutants and A beta prevents the formation of A beta fibrils. This suggests that CRP is a dual pattern recognition molecule and an antiamyloidogenic protein.

JOURNAL OF IMMUNOLOGY (2022)

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

Article Cell Biology

Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?

Zhengrong Zhang et al.

Summary: The ApoE4-mCRP-CD31 pathway was shown to facilitate communication between peripheral inflammation and cerebral vasculature, increasing the risk of AD. The interaction of endothelial CD31 with mCRP and ApoE led to shortened neurovasculature and cognitive impairment. Through studies in ApoE knock-in mice, it was found that mCRP could cause cerebrovascular damage by binding to CD31 on the endothelial surface.

AGING CELL (2021)

Article Medicine, Research & Experimental

Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes

Clara Ruiz-Fernandez et al.

Summary: This study demonstrates that monomeric C reactive protein (mCRP) exerts strong pro-inflammatory properties in chondrocytes, increasing the expression of various inflammatory mediators and proteolytic enzymes, thereby promoting breakdown of the extracellular matrix in cartilage.

LABORATORY INVESTIGATION (2021)

Article Immunology

Monomeric C-Reactive Protein Localized in the Cerebral Tissue of Damaged Vascular Brain Regions Is Associated With Neuro-Inflammation and Neurodegeneration-An Immunohistochemical Study

Raid S. Al-Baradie et al.

Summary: mCRP accumulation in brain tissues is closely associated with neurodegenerative processes related to injury and inflammation, likely playing a direct role in promoting tissue damage and supporting the progression of AD after injury.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Anti-Monomeric C-Reactive Protein Antibody Ameliorates Arthritis and Nephritis in Mice

Chitose Fujita et al.

Summary: Screening of over 1800 anti-mCRP mAb clones identified 3C as a clone recognizing the monomeric form of CRP, which showed therapeutic potential against rheumatoid arthritis and lupus nephritis in mouse models.

JOURNAL OF IMMUNOLOGY (2021)

Article Biochemistry & Molecular Biology

Monomeric C-reactive protein promotes platelets to release mitochondrial DNA in anti-neutrophil cytoplasmic antibody-associated vasculitis

Tong Chen et al.

Summary: mCRP can bind to platelets through lipid raft interaction, inducing mtDNA release and enhancing the pathogenicity of ANCA. The released mtDNA from activated platelets can also promote activation of the coagulation system in AAV.

MOLECULAR IMMUNOLOGY (2021)

Article Immunology

CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner

Johannes Zeller et al.

Summary: Research has shown that the activation of monomeric CRP can activate immune cells through the classical complement pathway, inducing the generation of ROS. This process is conformation-specific and complement-dependent, with classical monocytes being the primary source of ROS among human monocyte subsets.

FRONTIERS IN IMMUNOLOGY (2021)

Letter Immunology

Monomeric CRP is Elevated in Patients with COPD Compared to Non-COPD Control Persons

Revathy Munuswamy et al.

Summary: Chronic low-grade systemic inflammation is often seen in COPD patients, with mCRP being significantly elevated in COPD patients compared to non-COPD individuals, suggesting that mCRP could serve as a new sensitive biomarker for chronic low-grade systemic inflammation.

JOURNAL OF INFLAMMATION RESEARCH (2021)

Review Immunology

C-Reactive Protein and Cancer-Diagnostic and Therapeutic Insights

Peter C. Hart et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Matrix sieving-enforced retrograde transcytosis regulates tissue accumulation of C-reactive protein

Hai-Yun Li et al.

CARDIOVASCULAR RESEARCH (2019)

Article Biochemistry & Molecular Biology

An interaction between MKL1, BRG1, and C/EBPβ mediates palmitate induced CRP transcription in hepatocytes

Zhiwen Fan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2019)

Review Immunology

Evolution of C-Reactive Protein

Asmita Pathak et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

Functionality of C-Reactive Protein for Atheroprotection

Sanjay K. Singh et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Oxidation of C-reactive protein by hypochlorous acid leads to the formation of potent platelet activator

Magdalena Boncler et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

Article Multidisciplinary Sciences

Conformational folding and disulfide bonding drive distinct stages of protein structure formation

Jian-Min Lv et al.

SCIENTIFIC REPORTS (2018)

Article Immunology

An ELISA Assay for Quantifying Monomeric C-Reactive Protein in Plasma

Lin Zhang et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Immunology

C-Reactive Protein in Atherothrombosis and Angiogenesis

Lina Badimon et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Acidic pH promotes oxidation-induced dissociation of C-reactive protein

Shuo-Lei Li et al.

MOLECULAR IMMUNOLOGY (2018)

Article Biochemistry & Molecular Biology

Functional Transformation of C-reactive Protein by Hydrogen Peroxide

Sanjay K. Singh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Urology & Nephrology

Autoantibodies against C-Reactive Protein Influence Complement Activation and Clinical Course in Lupus Nephritis

Qiu-yu Li et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2017)

Review Multidisciplinary Sciences

Organotypic vasculature: From descriptive heterogeneity to functional pathophysiology

Hellmut G. Augustin et al.

SCIENCE (2017)

Article Multidisciplinary Sciences

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

David Braig et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein

Hai-Yun Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Cardiac & Cardiovascular Systems

Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein are Increased in Peripheral Artery Disease

Jeffrey R. Crawford et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2016)

Article Physiology

C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?

Melissa A. Pegues et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Article Physiology

Monomeric C-reactive protein inhibits renal cell-directed complement activation mediated by properdin

Joseph O'Flynn et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Review Biochemistry & Molecular Biology

C-reactive protein and inflammation: conformational changes affect function

Yi Wu et al.

BIOLOGICAL CHEMISTRY (2015)

Article Gastroenterology & Hepatology

Liver Sinusoidal Endothelial Cells in Hepatic Fibrosis

Laurie D. DeLeve

HEPATOLOGY (2015)

Article Biochemistry & Molecular Biology

Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637

Yoonseo Kim et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Biochemistry & Molecular Biology

Myeloperoxidase influences the complement regulatory function of modified C-reactive protein

Peng-cheng Xu et al.

INNATE IMMUNITY (2014)

Article Biochemistry & Molecular Biology

Topological Localization of Monomeric C-reactive Protein Determines Proinflammatory Endothelial Cell Responses

Hai-Yun Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Cardiac & Cardiovascular Systems

Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction

Jonathon Habersberger et al.

CARDIOVASCULAR RESEARCH (2012)

Article Biochemistry & Molecular Biology

Exposing a Hidden Functional Site of C-reactive Protein by Site-directed Mutagenesis

Sanjay K. Singh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

The Phosphocholine-binding Pocket on C-reactive Protein Is Necessary for Initial Protection of Mice against Pneumococcal Infection

Toh B. Gang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Rheumatology

Collagen-Induced Arthritis Is Exacerbated in C-Reactive Protein-Deficient Mice

Nicholas R. Jones et al.

ARTHRITIS AND RHEUMATISM (2011)

Article Biochemistry & Molecular Biology

A redox switch in C-reactive protein modulates activation of endothelial cells

Ming-Yu Wang et al.

FASEB JOURNAL (2011)

Article Biochemistry & Molecular Biology

Monomeric C-reactive protein modulates classic complement activation on necrotic cells

Michael Mihlan et al.

FASEB JOURNAL (2011)

Article Biochemistry & Molecular Biology

No Reduction of Atherosclerosis in C-reactive Protein (CRP)-deficient Mice

Daniel Teupser et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Review Immunology

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

Barbara Bottazzi et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 28 (2010)

Article Medical Laboratory Technology

C-Reactive Protein Uptake by Macrophage Cell Line via Class-A Scavenger Receptor

Yoshiko Fujita et al.

CLINICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Identification of Acidic pH-dependent Ligands of Pentameric C-reactive Protein

David J. Hammond et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Oncology

C-Reactive Protein and the Risk of Cancer: A Mendelian Randomization Study

Kristine H. Allin et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2010)

Article Biochemistry & Molecular Biology

Monomeric C-reactive protein activates endothelial cells via interaction with lipid raft microdomains

Shang-Rong Ji et al.

FASEB JOURNAL (2009)

Article Hematology

C-Reactive Protein Isoforms Differ in Their Effects on Thrombus Growth

Blanca Molins et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Complement Factor H Binds to Denatured Rather than to Native Pentameric C-reactive Protein

Svetlana Hakobyan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Medicine, General & Internal

Genetically elevated C-reactive protein and ischemic vascular disease

Jeppe Zacho et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Multidisciplinary Sciences

Human C-reactive protein slows atherosclerosis development in a mouse model with human-like hypercholesterolemia

Alexander Kovacs et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Immunology

C-reactive protein is expressed and secreted by peripheral blood mononuclear cells

D. G. Haider et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2006)

Letter Cardiac & Cardiovascular Systems

Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: Linking obesity to vascular inflammation

P Calabro et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2005)

Article Hematology

Role of C-reactive protein in atherogenesis - Can the apolipoprotein E knockout mouse provide the answer?

K Reifenberg et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)

Article Multidisciplinary Sciences

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice

GM Hirschfield et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Rheumatology

Reversal of ongoing proteinuria in autoimmune mice by treatment with C-reactive protein

W Rodriguez et al.

ARTHRITIS AND RHEUMATISM (2005)

Article Biochemistry & Molecular Biology

Native and modified C-reactive protein bind different receptors on human neutrophils

RM Heuertz et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2005)

Article Medicine, Research & Experimental

C-reactive protein: a critical update

MB Pepys et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Immunology

The kidney as a second site of human C-reactive protein formation in vivo

WJ Jabs et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

Article Transplantation

Tubular staining of modified C-reactive protein in diabetic chronic kidney disease

SB Schwedler et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2003)

Article Biochemistry & Molecular Biology

Loss of pentameric symmetry of C-reactive protein is associated with delayed apoptosis of human neutrophils

T Khreiss et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Secretory production of recombinant human C-reactive protein in Escherichia coli, capable of binding with phosphorylcholine, and its characterization

T Tanaka et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Biochemistry & Molecular Biology

Dissociation and subunit rearrangement of membrane-bound human C-reactive proteins

HW Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)

Review Biochemistry & Molecular Biology

Human C-reactive protein: expression, structure, and function

JE Volanakis

MOLECULAR IMMUNOLOGY (2001)

Article Pathology

Generation of C-reactive protein and complement components in atherosclerotic plaques

K Yasojima et al.

AMERICAN JOURNAL OF PATHOLOGY (2001)