☆ 4.6 Review

Regulation and Immunotherapeutic Targeting of the Epigenome in Exhausted CD8 T Cell Responses

JOURNAL OF IMMUNOLOGY (2023)

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Active Maintenance of T Cell Memory in Acute and Chronic Viral Infection Depends on Continuous Expression of FOXO1

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Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation

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Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted

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Dynamic DNA methylation: In the right place at the right time

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Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody

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SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells

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Chromatin states define tumour-specific T cell dysfunction and reprogramming

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Type I Interferon in Chronic Virus Infection and Cancer

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TRENDS IN IMMUNOLOGY (2017)

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An efficient targeted nuclease strategy for high-resolution mapping of DNA binding sites

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BACH transcription factors in innate and adaptive immunity

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NATURE REVIEWS IMMUNOLOGY (2017)

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De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation

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Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation

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NATURE IMMUNOLOGY (2017)

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Epigenomics of human CD8 T cell differentiation and aging

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SCIENCE IMMUNOLOGY (2017)

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Deciphering CD137 (4-1BB) signaling in T-cell costimulation for translation into successful cancer immunotherapy

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Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

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IMMUNITY (2016)

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CD8+ T Cells Utilize Highly Dynamic Enhancer Repertoires and Regulatory Circuitry in Response to Infections

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IMMUNITY (2016)

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Dynamic Changes in Chromatin Accessibility Occur in CD8+ T Cells Responding to Viral Infection

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IMMUNITY (2016)

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Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion

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JOURNAL OF VIROLOGY (2016)

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A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes

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MOLECULAR CELL (2016)

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BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

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NATURE IMMUNOLOGY (2016)

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Tcf1 and Lef1 transcription factors establish CD8+ T cell identity through intrinsic HDAC activity

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NATURE IMMUNOLOGY (2016)

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HiChIP: efficient and sensitive analysis of protein-directed genome architecture

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NATURE METHODS (2016)

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The epigenetic landscape of T cell exhaustion

Debattama R. Sen et al.

SCIENCE (2016)

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Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

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SCIENCE (2016)

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The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness

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SCIENCE IMMUNOLOGY (2016)

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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

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CELL (2015)

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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8+ T Cells

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IMMUNITY (2015)

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Single-cell chromatin accessibility reveals principles of regulatory variation

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Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

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NATURE GENETICS (2015)

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Review Immunology

Molecular and cellular insights into T cell exhaustion

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NATURE REVIEWS IMMUNOLOGY (2015)

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Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection

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MOLECULAR THERAPY (2014)

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Article Immunology

The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

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NATURE IMMUNOLOGY (2014)

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The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells

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Review Immunology

Remembering one's ID/E-ntity: E/ID protein regulation of T cell memory

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CURRENT OPINION IN IMMUNOLOGY (2013)

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PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

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JOURNAL OF CLINICAL INVESTIGATION (2013)

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Article Immunology

Global DNA Methylation Remodeling Accompanies CD8 T Cell Effector Function

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JOURNAL OF IMMUNOLOGY (2013)

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Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells

Ben Youngblood et al.

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BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

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NATURE (2013)

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T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion

Daniel T. Utzschneider et al.

NATURE IMMUNOLOGY (2013)

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

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ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

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Review Biochemistry & Molecular Biology

Structure and Function of Mammalian DNA Methyltransferases

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CHEMBIOCHEM (2011)

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Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells

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IMMUNITY (2011)

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Review Biochemistry & Molecular Biology

OPERating ON Chromatin, a Colorful Language where Context Matters

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JOURNAL OF MOLECULAR BIOLOGY (2011)

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Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

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DNA Methylation: A Timeline of Methods and Applications

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Frontiers in Genetics (2011)

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Epigenetic regulation of CD8+T-lymphocyte mediated suppression of HIV-1 replication

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Enhanced Antitumor Activity Induced by Adoptive T-Cell Transfer and Adjunctive Use of the Histone Deacetylase Inhibitor LAQ824

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Cell-Intrinsic Transforming Growth Factor-β Signaling Mediates Virus-Specific CD8+ T Cell Deletion and Viral Persistence In Vivo

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A Role for the Transcriptional Repressor Blimp-1 in CD8+ T Cell Exhaustion during Chronic Viral Infection

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IMMUNITY (2009)

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Insertional chromatin immunoprecipitation: A method for isolating specific genomic regions

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JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2009)

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Chronic Antigen Stimulation Alone Is Sufficient to Drive CD8+ T Cell Exhaustion

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An oestrogen-receptor-α-bound human chromatin interactome

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ChIP-seq: advantages and challenges of a maturing technology

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NATURE REVIEWS GENETICS (2009)

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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

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Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

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Combinatorial patterns of histone acetylations and methylations in the human genome

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NATURE GENETICS (2008)

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Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor

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IMMUNITY (2007)

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Interleukin-10 determines viral clearance or persistence in vivo

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Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions

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Resolution of a chronic viral infection after interleukin-10 receptor blockade

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Chromosome Conformation Capture Carbon Copy (5C): A massively parallel solution for mapping interactions between genomic elements

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TOX defines a conserved subfamily of HMG-box proteins

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BMC GENOMICS (2003)

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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

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Capturing chromosome conformation

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The language of covalent histone modifications

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