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Article
Gastroenterology & Hepatology
Alessandro Vitale et al.
Summary: This study compared patients with MAFLD and non-MAFLD who had hepatocellular carcinoma (HCC) in Italy. It found that the proportion of MAFLD in HCC patients was increasing over time and is expected to surpass non-MAFLD in the future. Despite a later cancer stage at diagnosis, MAFLD HCC patients had a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
Review
Gastroenterology & Hepatology
Neehar D. Parikh et al.
Summary: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths globally due to inadequate early detection strategies. Current screening recommendations have several deficiencies, including suboptimal sensitivity and poor adherence. Blood-based biomarkers show promise but require validation and logistical solutions before clinical implementation. Maturing validation cohorts, such as the Hepatocellular Carcinoma Early Detection Study and the Texas Hepatocellular Carcinoma Consortium, are expected to provide robust validation for candidate biomarkers.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Nicole E. Rich et al.
Summary: Overdiagnosis refers to the detection of diseases that would not have become apparent during a patient's lifetime. It can have serious negative consequences including overtreatment, financial toxicity, and psychological harm. Overdiagnosis can occur due to inaccurate diagnostic criteria, early detection of malignant lesions, indolent tumors, and competing risks of mortality. Guideline recommendations can help mitigate the risk, but more research is needed to understand and reduce overdiagnosis.
Article
Gastroenterology & Hepatology
Amit G. Singal et al.
Summary: In this systematic review and meta-analysis, HCC surveillance was found to be associated with improved early-stage detection, curative treatment receipt, and survival in patients with cirrhosis. However, there was significant heterogeneity in the pooled estimates, and there were fewer data quantifying potential surveillance-related harms. Available data suggest that HCC surveillance is of high value in patients with cirrhosis, although further studies evaluating benefits and harms are still needed.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Neehar D. Parikh et al.
Summary: Sustained viral response (SVR) improves survival for patients with hepatitis C (HCV) and hepatocellular carcinoma (HCC) after curative treatment, but the benefit of SVR in patients with active HCC and significant competing risk of mortality is unknown. This study aimed to evaluate the association between SVR and outcomes in patients with active HCC.
Review
Gastroenterology & Hepatology
Erin Wolf et al.
Summary: The study found that HCC surveillance is underused in clinical practice, especially among patients with alcohol-associated or NASH-related cirrhosis and those not followed in subspecialty gastroenterology clinics. Interventions such as provider education, inreach including reminder systems, and population health outreach efforts can significantly increase HCC surveillance.
Article
Gastroenterology & Hepatology
Patrick Marquardt et al.
Summary: The main reasons for underuse of HCC screening in patients with cirrhosis are lack of regular outpatient care and lack of screening orders in those with known cirrhosis, highlighting the need for interventions at these steps to increase HCC screening utilization.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Nicole E. Rich et al.
Article
Gastroenterology & Hepatology
Debra T. Choi et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Oncology
Philip Gerlee
