期刊
JOURNAL OF HEMATOLOGY & ONCOLOGY
卷 16, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13045-023-01423-7
关键词
COVID-19; Passive immunization; Tixagevimab; cilgavimab; Hematologic malignancies
This study reports breakthrough COVID-19 infections in hematologic malignancies patients who received prophylactic tixagevimab/cilgavimab. Most patients had lymphoproliferative disorders and were infected with the omicron variant. The use of tixagevimab/cilgavimab appears to reduce the severity of COVID-19 in these patients, but further studies are needed to determine the optimal drug administration strategies for immunocompromised patients.
Only few studies have analyzed the efficacy of tixagevimab/cilgavimab to prevent severe Coronavirus disease 2019 (COVID-19) and related complications in hematologic malignancies (HM) patients. Here, we report cases of breakthrough COVID-19 after prophylactic tixagevimab/cilgavimab from the EPICOVIDEHA registry). We identified 47 patients that had received prophylaxis with tixagevimab/cilgavimab in the EPICOVIDEHA registry. Lymphoproliferative disorders (44/47, 93.6%) were the main underlying HM. SARS-CoV-2 strains were genotyped in 7 (14.9%) cases only, and all belonged to the omicron variant. Forty (85.1%) patients had received vaccinations prior to tixagevimab/cilgavimab, the majority of them with at least two doses. Eleven (23.4%) patients had a mild SARS-CoV-2 infection, 21 (44.7%) a moderate infection, while 8 (17.0%) had severe infection and 2 (4.3%) critical. Thirty-six (76.6%) patients were treated, either with monoclonal antibodies, antivirals, corticosteroids, or with combination schemes. Overall, 10 (21.3%) were admitted to a hospital. Among these, two (4.3%) were transferred to intensive care unit and one (2.1%) of them died. Our data seem to show that the use of tixagevimab/cilgavimab may lead to a COVID-19 severity reduction in HM patients; however, further studies should incorporate further HM patients to confirm the best drug administration strategies in immunocompromised patients.
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