Early United States experience with lung donation after circulatory death using thoracoabdominal normothermic regional perfusion

Article Surgery

Successful lung transplantation with graft recovered after thoracoabdominal normothermic perfusion from donor after circulatory death

Marian Urban et al.

Summary: Lung transplantation from donors after circulatory death is now seen as a viable alternative to traditional brain death donation. The emergence of TA-NRP as a technique for cardiac allograft procurement from circulatory death cases allows for in situ organ assessment, potentially impacting lung allograft quality. However, successful cases of transplantation using this method have been reported.

AMERICAN JOURNAL OF TRANSPLANTATION (2022)

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Article Cardiac & Cardiovascular Systems

Early experience with donation after circulatory death heart transplantation using normothermic regional perfusion in the United States

Deane E. Smith et al.

Summary: The feasibility of a donation after circulatory death (DCD) heart transplantation protocol using cardiopulmonary bypass (CPB) for normothermic regional reperfusion (NRP) was evaluated in this pilot study. The study showed excellent outcomes of DCD heart transplantation, indicating the potential for wider adoption of the DCD protocol and increased availability of donor hearts in the United States.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

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Article Surgery

Novel Use of Mobile Ex-Vivo Lung Perfusion in Donation After Circulatory Death Lung Transplantation

Marian Urban et al.

PROGRESS IN TRANSPLANTATION (2022)

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Article Cardiac & Cardiovascular Systems

Controlled DCD lung transplantation: Circumventing imagined and real barriers - time for an international taskforce?

Aleem Siddique et al.

Summary: Controlled donation after circulatory death (DCD) has the potential to increase the number of lung transplants and address the organ shortage. This study examines the benefits and barriers of increasing DCD utilization and provides solutions for expanding DCD utilization across centers and nations.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2022)

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Editorial Material Critical Care Medicine

Does Normothermic Regional Perfusion Violate the Ethical Principles Underlying Organ Procurement? Yes

Matthew DeCamp et al.

CHEST (2022)

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Article Cardiac & Cardiovascular Systems

Predictors of nonuse of donation after circulatory death lung allografts

Ashley Y. Choi et al.

Summary: The study found that nontransplantation of donation after circulatory death lungs was associated with potentially modifiable factors such as smoking history, clinical infection, and low PaO2/FiO(2) ratio. Furthermore, interventions to increase consent and standardize donation after circulatory death donor management, including selective use of ex vivo lung perfusion, may increase use and the donor pool.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Transplantation of donor hearts after circulatory death using normothermic regional perfusion and cold storage preservation

Katrien Vandendriessche et al.

Summary: This study investigates the safety and feasibility of heart transplantation after circulatory death using thoraco-abdominal normothermic regional perfusion and subsequent cold storage. The results show a 100% survival rate and good cardiac function in four procedures.

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY (2021)

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Article Cardiac & Cardiovascular Systems

Early US experience with cardiac donation after circulatory death (DCD) using normothermic regional perfusion

Jordan R. H. Hoffman et al.

Summary: This study conducted heart transplantations using DCD allografts, extending cold ischemic time with TA-NRP and cold static storage, which improved the feasibility and success rate of heart transplantation.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

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Article Cardiac & Cardiovascular Systems

Donor heart and lung procurement: A consensus statement

Hannah Copeland et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Early United States experience with lung donation after circulatory death using thoracoabdominal normothermic regional perfusion

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