4.8 Article

Injectable 2D MoS2-Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia

期刊

ADVANCED MATERIALS
卷 27, 期 44, 页码 7117-+

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503869

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资金

  1. China National Funds for Distinguished Young Scientists [51225202]
  2. National Natural Science Foundation of China [51072212]
  3. Shanghai Excellent Academic Leaders Program [14XD1403800]
  4. Shanghai technical platform for testing and characterization on inorganic materials [14DZ2292900]
  5. China Postdoctoral Science Foundation [2014M551463]

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MoS2 nanosheets and a doxorubicin (DOX)-containing poly(lactic-co-glycolic acid) (PLGA)/MoS2/DOX composite implant are successfully constructed based on the unique phase-changing behavior of PLGA/MoS2/DOX oleosol within tumors. The fast phase transformation can firmly restrict MoS2 and DOX within tumors, and the integrated MoS2 and DOX can endow the implant with high synergistic photothermal and chemotherapeutic efficiency against tumors.

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