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Article
Multidisciplinary Sciences
Peggy Eby et al.
Summary: In recent decades, pathogens originating from bats have become a growing concern for public health, as they pose a pandemic threat. Many studies have linked the transmission of these pathogens to changes in land use or other human-induced stressors, although the exact mechanisms are still unknown. The lack of comprehensive data on multiple spillovers and their connections with reservoir host ecology, behavior, and viral dynamics has been a major limitation.
Article
Multidisciplinary Sciences
Zhiqiang Wu et al.
Summary: In this study, 146 new bat sarbecoviruses were discovered through screening pharyngeal and anal swabs from 13,064 bats collected across China. The research suggests that the circulation of SARS-CoV-2 in China is limited, while SARS-CoV may have a broader presence. Further surveys in broader geographical regions are necessary to find the most recent ancestors of human sarbecoviruses.
NATIONAL SCIENCE REVIEW
(2023)
Article
Immunology
Xingyu Li et al.
Summary: The study reveals a novel mechanism by which ORF10 of SARS-CoV-2 inhibits the innate immune response through inducing mitophagy-mediated MAVS degradation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Evolutionary Biology
Spyros Lytras et al.
Summary: The study suggests that horseshoe bats in southern China and Southeast Asia are likely the reservoir species for the proximal animal ancestor of SARS-CoV-2. The research also reveals recent geographic movement and cocirculation of these viruses' ancestors. However, a direct proximal ancestor to SARS-CoV-2 has not been sampled yet, highlighting the need for more wildlife sampling to determine the exact origins, intermediate species involved in transmission, and the diversity of related sarbecoviruses that pose a high risk for future spillovers.
GENOME BIOLOGY AND EVOLUTION
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yujia Alina Chan et al.
Summary: The unique furin cleavage site in SARS-CoV-2 has sparked discussions about the virus's origin, as it is under strong selective pressure in humans and enhances the virus's ability to infect cells and induce cell fusion. Scientists are interested in studying novel cleavage sites by introducing them into other SARS-related coronaviruses, and future wildlife coronavirus sampling may impact the interpretation of existing data.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Vanessa L. Hale et al.
Summary: Research shows that free-ranging white-tailed deer in northeast Ohio, USA are highly susceptible to SARS-CoV-2 infection, potentially enabling the virus to be transmitted in wildlife, opening up new pathways for evolution.
Article
Infectious Diseases
Sophie M. Common et al.
Summary: The study analyzed the risks of SARS-CoV-2 disease to free-living bat species in England through fieldworkers undertaking conservation activities, finding that the probability of exposure to bats ranged from negligible to high depending on proximity to infected individuals. The likelihood of infection and dissemination of the virus through bat populations was estimated to be high and medium, respectively, with a low likelihood of clinical disease occurring in infected bats.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Sergey Alkhovsky et al.
Summary: Two novel SARS-like coronaviruses were discovered and genetically described in horseshoe bats in southern regions of Russia. The study also found evidence of recombination events in the evolutionary history of one of the viruses.
Review
Infectious Diseases
Myriam Logeot et al.
Summary: The review paper evaluated the susceptibilities of different free-ranging wild animal species in Belgium to SARS-CoV-2 and highlighted the need for close attention to the risks of infection in wild animals, particularly those collected in rescue centers, emphasizing the importance of surveillance and awareness-raising activities.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemical Research Methods
Dmitry Meleshko et al.
Summary: The development of coronaSPAdes has significantly improved the recovery of full-length RNA viral genomes, outperforming existing SPAdes modes and other popular short-read metagenome and viral assemblers. Leveraging knowledge about viral genome structures, coronaSPAdes extends ideas initially implemented in biosyntheticSPAdes.
Article
Biochemistry & Molecular Biology
Diego Forni et al.
Summary: This study systematically investigated the accessory proteins encoded by coronaviruses using a homology detection method. The results showed that accessory proteins are distributed differently among different coronavirus genera, with betacoronaviruses having the highest average number of accessory proteins per genome. The analysis of evolutionary history revealed similar evolutionary strategies adopted by different coronavirus genera.
Article
Biology
Renata L. Muylaert et al.
Summary: Human encroachment into natural habitats and carbon emissions are causing global changes that are driving biodiversity extinction and increasing disease emergence risk. By modeling the ecological niche of bat hosts, we have identified hotspot distributions and future shifts in these hotspots.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Waleemas Jairak et al.
Summary: This study investigated SARS-CoV-2 infections in domestic dogs and cats in Thailand and found two cases of SARS-CoV-2 in a dog and a cat from COVID-19 positive households. Whole genome sequencing identified the delta variant of concern (B.1.617.2) in the isolated virus. Phylogenetic analysis revealed that the SARS-CoV-2 from the dog and cat belonged to sublineages AY.30 and AY.85, respectively. Antibodies against SARS-CoV-2 were detected in both the dog (day 9) and cat (day 14) after viral RNA detection. This study highlights the importance of monitoring SARS-CoV-2 in domestic pets due to the potential spill-over of variants of concern.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Anna-Lena Sander et al.
Summary: Genomic analyses of European bat SARS-related coronaviruses suggest that furin cleavage sites can be acquired in the bat reservoir via conserved molecular mechanisms, supporting a natural origin of SARS-CoV-2. The study reveals molecular features in SrC that resemble those required for furin cleavage site acquisition in avian influenza viruses.
COMMUNICATIONS BIOLOGY
(2022)
Article
Microbiology
Bradley Pickering et al.
Summary: This study conducted observational surveillance in Ontario, Canada and found a highly divergent lineage of SARS-CoV-2 in white-tailed deer. Genetic analysis suggests a shared ancestry with mink-derived virus and reveals an epidemiologically linked human infection. These findings provide evidence for sustained evolution and deer-to-human transmission of SARS-CoV-2 in white-tailed deer, highlighting their potential as reservoirs for viral variants.
NATURE MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Katriina Willgert et al.
Summary: Understanding the risk and direction of SARS-CoV-2 transmission between humans and potential reservoir hosts is crucial for disease control. Research has found no evidence of direct or indirect transmission from deer to humans, but spillback to humans cannot be ruled out.
SCIENTIFIC REPORTS
(2022)
Review
Veterinary Sciences
J. A. Quinteros et al.
Summary: This paper provides a comprehensive review of general aspects of coronaviruses and specifically focuses on IBV, including protein functions and pathogenesis. The pathogenicity of Australian strains of IBV is discussed, highlighting the variability among different groups of strains.
AUSTRALIAN VETERINARY JOURNAL
(2022)
Article
Veterinary Sciences
Vicki Thayer et al.
Summary: Feline infectious peritonitis (FIP) is one of the most important infectious diseases in cats, especially affecting young cats. Diagnosing FIP can be challenging due to the lack of specific clinical signs or laboratory changes. Obtaining a correct diagnosis is critical for effective treatment.
JOURNAL OF FELINE MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Marisa E. McGrath et al.
Summary: The ongoing COVID-19 pandemic continues to pose a major public health crisis. This study investigates the impact of viral variants on pathogenesis and replication of SARS-CoV-2. The findings suggest that both spike protein mutations and mutations in accessory proteins can contribute to disease severity and replication of the virus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Virology
Anna Orlowska et al.
Summary: This study reports the detection of bat coronaviruses (BtCoVs) in insectivorous bats in Poland, including SARS-related coronaviruses. The results highlight the prevalence and geographical distribution of coronaviruses in bat populations, confirming the high host restriction of these viruses. The findings provide insight into the molecular epidemiology of coronaviruses in bats.
Review
Virology
Yuanzhu Zhang et al.
Summary: This article reviews the latest progress in the biology of PEDV, including its transmission and origin, structure and function, evolution, and virus-host interaction, in an attempt to find potential virulence factors influencing PEDV pathogenesis. The findings serve as a valuable reference for the development of vaccines and control of infection.
Article
Microbiology
Stephanie N. Seifert et al.
Summary: The spillover of sarbecoviruses from animals to humans has caused outbreaks of SARS-CoVs and the ongoing COVID-19 pandemic. The study found that sarbecoviruses circulating in wildlife, including a virus found in Russian horseshoe bats, have the potential to infect human cells and evade antibodies from SARS-CoV-2.
Review
Microbiology
Georgios Pappas et al.
Summary: Amidst the ongoing COVID-19 pandemic, it is crucial to assess the interaction between SARS-CoV-2 and animal populations. Some animals can become infected and transmit the virus to other animals, which may lead to local outbreaks, viral mutations, and potential spillover to humans. This comprehensive review explores the available data on SARS-CoV-2 infections in different animal species, highlighting lessons learned from mink outbreaks, white-tailed deer endemicity, zoo outbreaks, threats to species conservation, the possible role of rodents in variant evolution (e.g., Omicron), and the importance of considering pets as potential reservoirs of the virus. The article emphasizes the need for a holistic approach to pandemics and epidemics, incorporating the principles of One Health and Planetary Health.
Article
Genetics & Heredity
Sejla Goletic et al.
Summary: This study conducted research in households in Bosnia and Herzegovina and found that three dogs and one cat were infected with SARS-CoV-2, with the viral genetic sequences in dogs matching those of their owners. These findings emphasize the importance of precautionary measures to protect both humans and animals.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Thanit Sila et al.
Summary: A veterinarian in Thailand was diagnosed with COVID-19 after being sneezed on by an infected cat, supporting the hypothesis of SARS-CoV-2 transmission from the owner to the cat and then from the cat to the veterinarian.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Dorothee Bienzle et al.
Summary: This study investigated the infection of pets in households in Ontario, Canada with human COVID-19 cases. The results showed that 2% of dog swab specimens and 7.7% of cat swab specimens were PCR positive, and 41% of dog serum samples and 52% of cat serum samples were positive for SARS-CoV-2 IgG or IgM. In addition, the risk of seropositivity was higher for cats that slept on owners' beds and for dogs and cats that contracted a new illness.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Biodiversity Conservation
Scott Jones et al.
Summary: This study proposes a method for detecting SARS-CoV-2 in bats using fecal sampling. Bats in the United Kingdom were tested and found to be negative for the virus. This research is important for understanding and mitigating the transmission of SARS-CoV-2 to wild animals.
CONSERVATION SCIENCE AND PRACTICE
(2022)
Review
Virology
Margaret J. Hosie et al.
Summary: COVID-19 is a severe acute respiratory syndrome caused by a new coronavirus, SARS-CoV-2, which has high contagiousness and has led to a global pandemic. Cats are susceptible to SARS-CoV-2 infection, especially in households with close contact with humans.
Article
Virology
Darren P. Martin et al.
Summary: The RDP project has developed an automated recombination analysis tool, RDP5, which is faster and more efficient than its predecessor, RDP4. Users can now analyze larger and more complex datasets with minimal manual intervention, allowing for greater flexibility and output options.
Article
Infectious Diseases
Helle Daugaard Larsen et al.
Summary: During June-November 2020, SARS-CoV-2-infected mink were found in 290 out of 1,147 Danish mink farms. In North Denmark Region, 30% of individuals associated with mink farms tested positive for SARS-CoV-2, and approximately 27% of SARS-CoV-2 strains in the community were linked to mink. Despite measures taken, the virus spread was not effectively controlled, leading to the government ordering the culling of all Danish mink as they pose a potential virus reservoir that challenges pandemic control.
Review
Multidisciplinary Sciences
Juan Li et al.
Summary: Since the emergence of COVID-19 in Wuhan in 2019, the world has faced a devastating pandemic with millions of cases and fatalities. This article provides insights into the spread and genetic variations of the SARS-CoV-2 virus, emphasizes the importance of genomic surveillance, and highlights the international transmission of major variants identified late in 2020.
Article
Multidisciplinary Sciences
Lu Lu et al.
Summary: In the first wave of the COVID-19 pandemic, SARS-CoV-2 was detected in mink farms in April 2020, leading to infections in minks and farm workers. The virus spread rapidly between mink farms, with a significant mutation in the Spike protein. Movement of people and distance between farms were significant predictors in viral dissemination between farms.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Petr Danecek et al.
Summary: SAMtools and BCFtools are widely used tools for processing high-throughput sequencing data, with a history of 12 years of continuous development and improvement. These packages have been utilized in various software projects and genomic pipelines and are freely available on GitHub.
Article
Multidisciplinary Sciences
Julien Cappelle et al.
Summary: Recent studies have shown that coronaviruses are widely circulated in Southeast Asian bat species, with indications that the SARS-CoV-2 virus may have originated in rhinolophid bats in the region. The research from Cambodia indicates a correlation between positive coronavirus detections and juvenile and immature bats, suggesting seasonal patterns in CoV circulation. Long-term monitoring and understanding of bat ecology in Southeast Asia are needed for biodiversity conservation and public health reasons.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Chrissy D. Eckstrand et al.
Summary: The study on the outbreak of SARS-CoV-2 in mink farms in Utah revealed rapid spread of the virus among mink, causing severe respiratory disease and death. The infected mink exhibited symptoms such as sudden death, anorexia, and increased respiratory effort. The findings emphasize the importance of biosecurity measures to prevent transmission from mink to humans.
Correction
Microbiology
Maya Shemesh et al.
Article
Biochemistry & Molecular Biology
Hong Zhou et al.
Summary: A study in Yunnan province, China, found the existence of bat coronaviruses related to both SARS-CoV-2 and SARS-CoV, with RpYN06 virus being the closest relative of SARS-CoV-2. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest hot-spots extending from South Laos and Vietnam to southern China. The study highlights the remarkable diversity of bat coronaviruses at the local scale.
Review
Biochemistry & Molecular Biology
Edward C. Holmes et al.
Summary: This article critically reviews the current scientific evidence to help clarify the origin of SARS-CoV-2. Recent debate has centered around two competing ideas: a laboratory escape scenario and zoonotic emergence.
Review
Virology
Puxian Fang et al.
Summary: Coronavirus accessory proteins, though dispensable for replication in vitro, play crucial roles in regulating immunity, proliferation, and pathogenicity. Their function in virus infection and pathogenesis, particularly in interaction with host cells, is of significant interest.
Article
Multidisciplinary Sciences
Jack M. Crook et al.
Summary: The origin of the COVID-19 pandemic remains unknown, but researchers believe that the natural host of the progenitor sarbecovirus is Asian horseshoe bats. A novel sarbecovirus (RhGB01) was discovered in a British horseshoe bat, showing 77% homology with SARS-CoV-2 and 81% with SARS-CoV. Although RhGB01 lacks hACE2 binding ability, it presents an opportunity for recombination with other sarbecoviruses. The study emphasizes the underestimation of the natural distribution of sarbecoviruses and the importance of preventing transmission to bats during the global vaccination campaign against SARS-CoV-2.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo Honorato et al.
Summary: Structural biology focuses on studying the structural and dynamic properties of biological macromolecules at atomic level, which is crucial for understanding cellular processes and has applications in health and food sciences. The WeNMR project has provided web-based services and high throughput computing infrastructure to over 23,000 users worldwide for 10 years, facilitating complex workflows in structural biology research.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biodiversity Conservation
Jonathan D. Cook et al.
Summary: The COVID-19 virus likely evolved in a mammalian host, possibly Old-World bats, before adapting to humans. Concerns have been raised regarding the possibility of reverse zoonotic transmission to bats. Recent studies have shown that the risk of transmitting SARS-CoV-2 to bats during fieldwork is lower than previously assessed, and can be significantly reduced by wearing high-efficiency filtration masks or obtaining a negative COVID-19 test before surveys.
CONSERVATION SCIENCE AND PRACTICE
(2021)
Article
Immunology
Lukasz Rabalski et al.
Summary: A study in northern Poland found that 15 out of 91 mink on a fur farm tested positive for SARS-CoV-2, with some carrying a variant with sporadic mutations in the spike protein. The study suggests implementing country-scale monitoring by veterinary inspection to detect SARS-CoV-2 in other mink farms.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Victor M. Corman et al.
Article
Microbiology
Maciej F. Boni et al.
NATURE MICROBIOLOGY
(2020)
Correction
Biochemistry & Molecular Biology
Bui Quang Minh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
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Multidisciplinary Sciences
Alice Latinne et al.
NATURE COMMUNICATIONS
(2020)
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Biochemistry & Molecular Biology
Carina Conceicao et al.
Review
Virology
Antonio C. P. Wong et al.
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Derrick E. Wood et al.
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Biochemistry & Molecular Biology
Diep Thi Hoang et al.
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(2018)
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Biochemical Research Methods
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Doreen Muth et al.
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Biochemical Research Methods
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Kazutaka Katoh et al.
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Andrea Balboni et al.
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Public, Environmental & Occupational Health
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