Macrophages and bone metastasis

In the prostate bone metastasis microenvironment, macrophages activate a cascade that involves Activin A, the extracellular matrix, and SRC kinase and drives resistance to anti-androgen therapy. These findings (Li et al., 2023. J. Exp. Med.https://doi.org/10.1084/jem.20221007) have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.

Automated summary

In the microenvironment of prostate bone metastasis, macrophages activate a cascade involving Activin A, the extracellular matrix, and SRC kinase, leading to resistance against anti-androgen therapy. These findings have broad implications, including metastasis diversity in different tissue milieus and the interplay between hormones and immunity.