4.7 Article

HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Intelligent Gold Nanoparticles with Oncogenic MicroRNA-Dependent Activities to Manipulate Tumorigenic Environments for Synergistic Tumor Therapy

Xiangdong Wang et al.

Summary: This study utilizes spherical nucleic acids (SNAs) to effectively utilize and manipulate oncogenic microRNAs for tumor therapy. SNAs capture overexpressed miR-21/miR-155 and exert their effects through gene therapy and chemotherapy, while also achieving photothermal therapy and enhancing tumor treatment outcomes.

ADVANCED MATERIALS (2022)

Review Biochemistry & Molecular Biology

Notch signaling pathway: architecture, disease, and therapeutics

Binghan Zhou et al.

Summary: The NOTCH gene and signaling pathway have been studied for 110 years and play important roles in the development, homeostasis, and related diseases of tissues and organs. However, recent studies have found that the outcomes of NOTCH signaling are context-dependent. In terms of cancer, NOTCH signaling can both promote and inhibit tumor development. NOTCH-targeted therapies in clinical trials have not met expectations, and NOTCH mutations may serve as predictive biomarkers for immune checkpoint blockade therapy in many cancers.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Pharmacology & Pharmacy

Dibenzazepine combats acute liver injury in rats via amendments of Notch signaling and activation of autophagy

Lamiaa A. Ahmed et al.

Summary: The study found that dibenzazepine can provide hepatoprotective effects in acute liver injury in rats, reducing the adverse effects of oxidative stress, inflammation, and apoptosis caused by paracetamol. Compared to silymarin, dibenzazepine showed superior results, possibly due to its more significant regulation of Notch signaling and autophagy.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

Review Oncology

Beyond conventional immune-checkpoint inhibition - novel immunotherapies for renal cell carcinoma

David A. Braun et al.

Summary: The management of advanced-stage renal cell carcinoma has been transformed by the development of immune-checkpoint inhibitors (ICIs). However, most patients do not derive durable clinical benefit from these agents. Innovations in immunotherapy for RCC, including ICIs with novel targets, are now in clinical development.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Biotechnology & Applied Microbiology

Targeting Notch in oncology: the path forward

Samarpan Majumder et al.

Summary: The Notch pathway in cancer has multifaceted roles, acting as both an oncogene and a tumor suppressor depending on the context. Despite potential, developing safe and effective Notch-targeting agents for clinical use remains challenging.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Medical Laboratory Technology

miR-138-5p inhibits proliferation and invasion in kidney renal clear cell carcinoma by targeting SINA3 and regulation of the Notch signaling pathway

Yang Liu et al.

Summary: This study demonstrated that up-regulated miR-138-5p inhibits the proliferation and invasion of KIRC cells by regulating the transcription of SIN3A and the activation of the Notch signaling pathway. MiR-138-5p was down-regulated in tumor tissues of KIRC patients compared to adjacent healthy tissues and was associated with a poor prognosis in patients. MiR-138-5p also hindered KIRC proliferation and invasion, while the artificial overexpression of SIN3A led to reversed trends. SIN3A was identified as a target mRNA of miR-138-5p, and together they played a role in modulating the Notch signaling pathway.

JOURNAL OF CLINICAL LABORATORY ANALYSIS (2021)

Article Chemistry, Multidisciplinary

Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal Cancer

Xuantong Zhou et al.

Summary: Radioresistance poses a significant challenge in clinical treatments, attributed to factors such as hypoxia in the tumor microenvironment, antioxidant systems in cancer cells, and upregulation of DNA repair proteins. A novel strategy involving GDY-CeO2 nanocomposites and miR181a shows promise in overcoming radioresistance and enhancing therapeutic efficacy in ESCC patients by mitigating hypoxia, promoting DNA damage, and facilitating personalized treatment.

ADVANCED MATERIALS (2021)

Review Cell Biology

MicroRNA-mediated regulation of glucose and lipid metabolism

Pamela Agbu et al.

Summary: MicroRNAs play a crucial role in regulating systemic metabolism, particularly glucose and lipid metabolism, and their misexpression can lead to metabolic diseases. They are emerging as potential therapeutic targets and metabolic biomarkers.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Biotechnology & Applied Microbiology

Noncoding RNA therapeutics - challenges and potential solutions

Melanie Winkle et al.

Summary: In recent years, RNA-based therapies have gained FDA approval, but there are still challenges in targeting ncRNAs. Therapeutic targeting of noncoding RNAs has the potential to become a new approach for treating diseases such as cancer.

NATURE REVIEWS DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

Nitin Roper et al.

Summary: This study identifies elevated Notch signaling as a significant predictor of clinical benefit in immune checkpoint blockade (ICB) for relapsed small cell lung cancer (SCLC) patients. Activation of Notch signaling induces a low NE phenotype, leading to increased expression of antigen processing and presentation machinery (APM) genes and improved intrinsic tumor immunity.

NATURE COMMUNICATIONS (2021)

Review Urology & Nephrology

Clear cell renal cell carcinoma ontogeny and mechanisms of lethality

Eric Jonasch et al.

Summary: The molecular features that define the initiation and progression of clear cell renal cell carcinoma (ccRCC) are increasingly being understood. Common genomic and chromosomal copy number abnormalities in ccRCC can be categorized into initiating events, drivers of progression, and factors that confer lethality. Mutations in specific genes in ccRCC may affect genomic stability and immune cell populations within tumors.

NATURE REVIEWS NEPHROLOGY (2021)

Review Urology & Nephrology

Oncometabolites in renal cancer

Cissy Yong et al.

NATURE REVIEWS NEPHROLOGY (2020)

Article Multidisciplinary Sciences

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Annika Fendler et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

MAML1-Dependent Notch-Responsive Genes Exhibit Differing Cofactor Requirements for Transcriptional Activation

Julia M. Rogers et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Targeting the HIF2-VEGF axis in renal cell carcinoma

Toni K. Choueiri et al.

NATURE MEDICINE (2020)

Review Oncology

Towards individualized therapy for metastatic renal cell carcinoma

Ritesh R. Kotecha et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Article Oncology

MicroRNA Dysregulation in Malignant Germ Cell Tumors: More Than a Biomarker?

Matthew J. Murray et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Review Oncology

Tumor Microenvironment Dynamics in Clear-Cell Renal Cell Carcinoma

Lynda Vuong et al.

CANCER DISCOVERY (2019)

Review Oncology

Notch signaling in breast cancer: From pathway analysis to therapy

B. Madhu Krishna et al.

CANCER LETTERS (2019)

Review Genetics & Heredity

Cross-regulation between Notch signaling pathway and miRNA machinery in cancer

Maryam Majidinia et al.

DNA REPAIR (2018)

Review Oncology

Notch Signaling in the Tumor Microenvironment

Olivier Meurette et al.

CANCER CELL (2018)

Review Cardiac & Cardiovascular Systems

Notch and interacting signalling pathways in cardiac development, disease, and regeneration

Donal MacGrogan et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Oncology

MiR-138: A promising therapeutic target for cancer

Huan-Huan Sha et al.

TUMOR BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Hes1: the maestro in neurogenesis

Sivadasan Bindu Dhanesh et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Review Biochemistry & Molecular Biology

HES1 in immunity and cancer

Aradhana Rani et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2016)

Review Oncology

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

Naoko Takebe et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

Article Oncology

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

Panagiotis Ntziachristos et al.

CANCER CELL (2014)

Article Medicine, Research & Experimental

miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways

Hui Wang et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Medicine, Research & Experimental

Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages

Yao Xiong et al.

LIFE SCIENCES (2014)

Review Endocrinology & Metabolism

Notch Signaling in Prostate Cancer: A Moving Target

Filipe L. F. Carvalho et al.

PROSTATE (2014)

Review Biochemistry & Molecular Biology

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells

Liyun Sang et al.

TRENDS IN MOLECULAR MEDICINE (2010)

Article Medicine, Research & Experimental

Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo

Jonas Sjolund et al.

JOURNAL OF CLINICAL INVESTIGATION (2008)