期刊
ADVANCED MATERIALS
卷 27, 期 34, 页码 5063-+出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502201
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资金
- Office of Science (BER), US Department of Energy [DE-SC0008397]
- NCI of Cancer Nanotechnology Excellence [CCNE-TR U54 CA119367, CA151459]
- National Basic Research Program of China [2012CB723402]
- National Natural Science Foundation of China [21222404, 61378081]
In order to promote imaging-guided chemotherapy for preclinical and clinical applications, endogenous nanosystems with both contrast and drug-delivery properties are highly desired. Here, the simple use of melanin is first reported, and this biopolymer with good biocompatibility and biodegradability, binding ability to drugs and ions, and intrinsic photoacoustic properties, can serve as an efficient endogenous nanosystem for imaging-guided tumor chemotherapy in living mice.
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