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Recombinant ferritins for multimodal nanomedicine

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2023)

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Article Chemistry, Multidisciplinary

Ferritin-Nanocaged ATP Traverses the Blood-Testis Barrier and Enhances Sperm Motility in an Asthenozoospermia Model

Jing Pang et al.

Summary: The use of ATP-loaded HFn nanocarrier can enhance sperm motility and serve as a potential drug-delivery system for treating asthenozoospermia. The nanocarrier is capable of traversing the blood-testis barrier and specifically targets the sperm heads without causing toxicity or affecting reproductive health in mice.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents

Changlong Wang et al.

Summary: The study demonstrates that shielding Fn with a CaP shell can enhance delivery performance by reducing interception in the liver and re-exposing it in acidic tumors, potentially leading to therapeutic effects.

ADVANCED MATERIALS (2022)

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Article Biochemistry & Molecular Biology

ACE2-derived peptides interact with the RBD domain of SARS-CoV-2 spike glycoprotein, disrupting the interaction with the human ACE2 receptor

Pedro F. N. Souza et al.

Summary: Through in silico methods, it was found that ACE2-derived peptides could potentially interfere with the interaction between SARS-CoV-2 and the ACE2 receptor, inhibiting virus entry into human cells and providing new directions for treating COVID-19.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

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Article Immunology

Ferritin-from iron, through inflammation and autoimmunity, to COVID-19

Naim Mahroum et al.

Summary: The role of ferritin in diseases goes beyond being an indicator of iron storage level, potentially playing a pathogenetic role. The discovery of hyperferritinemic syndrome has sparked research into the role of ferritin in COVID-19, aiming to better understand its involvement in diseases.

JOURNAL OF AUTOIMMUNITY (2022)

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Article Biochemistry & Molecular Biology

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

Katherine Houser et al.

Summary: This study evaluated the clinical trial results of a novel ferritin nanoparticle influenza vaccine platform called H2HA-Ferritin. The trial showed that the vaccine is safe and well tolerated, and it can elicit neutralizing antibody responses in both individuals who have not been exposed to the H2 subtype and those who have been exposed. Additionally, the vaccine also induced immune responses against multiple influenza subtypes. This vaccine technology has the potential for applications in pandemic preparedness and universal influenza vaccine development.

NATURE MEDICINE (2022)

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Article Medicine, Research & Experimental

Re-engineering the inner surface of ferritin nanocage enables dual drug payloads for synergistic tumor therapy

Zhuoran Wang et al.

Summary: In this study, a novel drug carrier called ins-FDC nanocage was developed. By optimizing the inner surface structure, this nanocarrier achieved high drug loading efficiency and programmed drug release pattern. The results showed that ins-FDC exhibited tumor targeting property and significantly enhanced the efficacy against glioma, metastatic liver cancer, and chemo-resistant breast tumors, while reducing side effects.

THERANOSTICS (2022)

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Article Biotechnology & Applied Microbiology

Self-assembling ferritin nanoparticles coupled with linear sequences from canine distemper virus haemagglutinin protein elicit robust immune responses

Bo Wang et al.

Summary: In this study, a new CDV vaccine was developed based on the sequence alignment of CDV hemagglutinin. The research found that self-assembling nanoparticles can enhance the immunogenicity of epitopes. The study also confirmed the long-term stability of the vaccine's immune effect and antibody potency through experiments.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Infectious Diseases

HIV and SARS-CoV-2: Tracing a Path of Vaccine Research and Development

Brittany Ober Shepherd et al.

Summary: This review examines the advances and obstacles in HIV vaccine research and their impact on the development of SARS-CoV-2 vaccines. The findings suggest that the technologies and knowledge gained from HIV research have positively influenced the development of vaccines for other viruses, including SARS-CoV-2. The investments into HIV biology have paved the way for the rapid development of safe and effective SARS-CoV-2 vaccines, presenting an opportunity for the development of HIV and other pathogen vaccines.

CURRENT HIV/AIDS REPORTS (2022)

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Article Chemistry, Applied

Construction of dual-compartmental micro-droplet via shrimp ferritin nanocages stabilized Pickering emulsions for co-encapsulation of hydrophobic/hydrophilic bioactive compounds

Hai Chen et al.

Summary: This study developed a dual-compartmental O/W Pickering emulsion system using ferritin nanocages as emulsifiers for the co-encapsulation of hydrophilic and hydrophobic bioactive compounds. The results showed that this system can form stable oil-in-water emulsions and improve the storage stability of bioactive compounds.

FOOD HYDROCOLLOIDS (2022)

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Review Biochemistry & Molecular Biology

Potential of Ferritin-Based Platforms for Tumor Immunotherapy

Xiaoling Xu et al.

Summary: This review summarizes the advantages and applications of ferritin as a tumor immunotherapy platform and highlights its potential as an immune vaccine or nanocarrier based on different targeting mechanisms. The review also discusses a ferritin-based tumor vaccine currently in phase I clinical trials that targets multiple variants of SARS-CoV-2. Despite the progress, there are still challenges to overcome, including drug loading, modification sites, and animal models. Overall, the ferritin-based nanoplatform shows great potential for tumor immunotherapy and clinical transformation.

MOLECULES (2022)

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Review Nanoscience & Nanotechnology

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Xiaodong Zhang et al.

Summary: Traditional enzymes have limitations in terms of cost, denaturation, and yield, while nanozymes, as a new type of artificial enzyme combining nanomaterials and enzymes, show promising potential in various applications due to their high catalytic activity and versatility.

NANO-MICRO LETTERS (2022)

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Review Oncology

Nanoparticles as Physically- and Biochemically-Tuned Drug Formulations for Cancers Therapy

Valentina Foglizzo et al.

Summary: Nanotechnology offers a solution to the limitations of conventional antitumor drugs by enabling targeted delivery and slow release of drugs, as well as development of cancer vaccines. Nanoparticle formulations have the potential to selectively kill cancer cells while sparing normal ones, making them promising tools for cancer therapy.

CANCERS (2022)

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Article Chemistry, Applied

The construction of self-protective ferritin nanocage to cross dynamic gastrointestinal barriers with improved delivery efficiency

Hai Chen et al.

Summary: A self-protective ferritin nanocarrier that can cross gastrointestinal barriers has been prepared through phosphorylation modification, exhibiting good digestive stability and high retention rate.

FOOD CHEMISTRY (2022)

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Review Biotechnology & Applied Microbiology

Ferritin nanocage based delivery vehicles: From single-, co- to compartmentalized- encapsulation of bioactive or nutraceutical compounds

Hai Chen et al.

Summary: Ferritin protein nanocages have emerged as one of the most promising vehicles for the encapsulation and delivery of bioactive ingredients or drugs. Their unique structure and disassembly/reassembly behavior make them highly effective and safe as delivery systems. This review focuses on the encapsulation strategies, advantages, and drawbacks of ferritin nanocages, and emphasizes the importance of their usage in compartmentalized delivery systems construction.

BIOTECHNOLOGY ADVANCES (2022)

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Article Chemistry, Multidisciplinary

Near-Field Nanoscopic Terahertz Imaging of Single Proteins

Zhongbo Yang et al.

Summary: A graphene-mediated THz scattering-type scanning near-field optical microscope is developed for direct imaging of single proteins, demonstrating that a graphene substrate with high THz reflectivity and atomic flatness provides high THz contrast against protein molecules. The use of an optimized length platinum probe enhances the amplitude of scattered THz near-field signals, allowing the topographical and THz scattering images of individual IgG and ferritin molecules with a few nanometers in size to be obtained simultaneously. This strategy opens up new avenues for imaging single biomolecules with THz.

SMALL (2021)

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Article Agriculture, Multidisciplinary

Chaotrope-Controlled Fabrication of Ferritin-Salvianolic Acid B- Epigallocatechin Gallate Three-Layer Nanoparticle by the Flexibility of Ferritin Channels

Shengnan Chen et al.

Summary: A novel approach was proposed to prepare ferritin-salvianolic acid B-epigallocatechin gallate (EGCG) three-layer nanoparticles (FSE) through the steric hindrance of ferritin channels, which increased the stability of EGCG in the nanoparticles due to the binding of salvianolic acid B to the outer interface of ferritin.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice

Abigail E. Powell et al.

Summary: By displaying SARS-CoV-2 spike proteins on ferritin nanoparticles, there was a notable enhancement in the elicitation of neutralizing antibodies, making it a viable strategy for single-dose vaccination against COVID-19.

ACS CENTRAL SCIENCE (2021)

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Review Pharmacology & Pharmacy

Recombinant protein vaccines, a proven approach against coronavirus pandemics

Jeroen Pollet et al.

Summary: This article points out that recombinant protein vaccines may become a favorable option in the context of the COVID-19 pandemic, despite being overlooked in early development, they may offer an advantage or complement under the current circumstances.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Nanoscience & Nanotechnology

tLyP-1 Peptide Functionalized Human H Chain Ferritin for Targeted Delivery of Paclitaxel

Yuanmeng Ma et al.

Summary: The study demonstrated that by functionalizing tLyP-1 at the N-terminal of ferritin, there was enhanced intracellular delivery of PTX, better cytotoxicity, and anti-invasion capability against both MDA-MB-231 and SMMC-7721 cells. Improved penetrability and growth inhibitory effects on SMMC-7721 tumor spheroids were also observed.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Neurosciences

New Insights into the Role of Ferritin in Iron Homeostasis and Neurodegenerative Diseases

Na Zhang et al.

Summary: Iron deposition is a key factor in neuronal death in neurodegenerative diseases, with ferritin playing an important role in maintaining iron homeostasis. Recent discoveries suggest that ferritin may not only store iron within cells but also regulate tissue and body iron balance. The relationship between ferritin and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease is significant, highlighting the potential importance of understanding ferritin's role in the brain.

MOLECULAR NEUROBIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages

Umesh Kalathiya et al.

Summary: SARS-CoV-2 enters human host cells by binding the spike protein to the ACE2 receptor. Mutations in the spike protein can affect this interaction, making the spike RBD a key target for vaccine development. Researchers have designed a spike RBD-based subunit vaccine using a ferritin protein nanocage as a scaffold, showing promise in potential new vaccine therapeutics against viruses like SARS-CoV-2.

BIOMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Genetically Modified Ferritin Nanoparticles with Bone-Targeting Peptides for Bone Imaging

Jong-Won Kim et al.

Summary: This study reported the synthesis of bone-targeting ferritin nanoparticles for bone imaging, using bone-targeting peptides genetically fused to the human ferritin to achieve specific binding with osteoblasts and hydroxyapatite. The promising results demonstrate the specific binding ability of the nanoscale targeting system to bone tissue, potentially for future clinical applications in bone disease therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Functionalizing Ferritin Nanoparticles for Vaccine Development

Margarida Q. Rodrigues et al.

Summary: In the last decade, interest in ferritin-based vaccines has been growing due to their safety and immunogenicity. Phase I clinical trials for candidates targeting various pathogens are currently underway. However, challenges related to manufacturing and standardizing production processes need to be addressed to make ferritin-based therapeutics more widely available.

PHARMACEUTICS (2021)

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Review Immunology

Antibodies Targeting the Transferrin Receptor 1 (TfR1) as Direct Anti-cancer Agents

Pierre V. Candelaria et al.

Summary: TfR1, also known as CD71, plays a critical role in cellular iron uptake by binding to transferrin. Its overexpression in malignant cells is associated with poor prognosis in different types of cancer. Targeting TfR1 with antibodies has shown potential as a direct anti-tumor therapy.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Pharmacology & Pharmacy

Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier

Baoli Zhang et al.

Summary: Ferritin has been recognized as an ideal drug delivery vehicle due to its unique structure and targeting ability, showing great potential in the biomedical field. Dynamic nanoassembly-based ferritin drug carrier (DNFDC) is a more flexible and intelligent platform that can achieve dynamic transformation upon stimuli for specific therapeutic functions at targeted sites.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Biochemistry & Molecular Biology

Bioengineered Ferritin Nanocarriers for Cancer Therapy

Xuanrong Sun et al.

Summary: Ferritin is a versatile nanocarrier for encapsulating anticancer drugs and imaging probes, with reversible assembling and disassembling properties. Its chemically and genetically modifiable surface allows for tumor-specific targeting, and as a biocompatible carrier, it stabilizes and protects enclosed particles. Recent studies demonstrate ferritin's potential as a multifunctional nanocarrier for targeted cancer therapy, combining chemotherapy with phototherapy for more effective tumor treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Conservative and Atypical Ferritins of Sponges

Kim Adameyko et al.

Summary: Ferritins are a conservative family of proteins found in all species, playing essential roles in resistance to redox stress, immune response, and cell differentiation. The study characterized ferritins in two cold-water sponges, revealing their regulation by cellular iron and oxygen levels, and their importance in various biological processes. Further research is needed to explore the function of atypical ferritins lacking iron-binding capacity in invertebrate species.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Identification and application of a neutralizing epitope within alpha-hemolysin using human serum antibodies elicited by vaccination

Jinning Wei et al.

Summary: In this study, sera from volunteers in a phase 1b clinical trial of a novel recombinant five-antigen SA vaccine (NCT03966040) were analyzed, and Hla(121-138) was identified as a neutralizing epitope. Furthermore, ferritin nanoparticles carrying the neutralizing Hla(121-138) epitope (EpNP) were successfully produced in E. coli, forming homogeneous nanoparticles in aqueous solution. Immunization with EpNP induced potent hemolysis-neutralizing antibodies and provided significant protection in a mouse model of SA skin infection.

MOLECULAR IMMUNOLOGY (2021)

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Review Clinical Neurology

Restless Legs Syndrome: Contemporary Diagnosis and Treatment

Thomas R. Gossard et al.

Summary: Restless legs syndrome is a condition characterized by uncomfortable urge to move legs while at rest, worsened symptoms at night, and can be primary or secondary to various causes. Treatment options include iron-replacement therapy and dopamine agonists, with intravenous iron infusion or opioids considered for severe symptoms or intolerance.

NEUROTHERAPEUTICS (2021)

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Article Chemistry, Multidisciplinary

One-step construction of ferritin encapsulation drugs for cancer chemotherapy

Ippei Inoue et al.

Summary: A novel, high-yield method for preparing high drug-loaded ferritin nanomedicine has been established, allowing for the successful introduction of various types of drug molecules into ferritin nano-cages. By incubating ferritin with a target drug at an appropriate pH, a complex is formed which enables efficient drug loading and higher drug recovery rates. This simple one-step method shows promise as a powerful production process for constructing drug-loaded ferritin carriers for drug delivery systems.

NANOSCALE (2021)

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Review Clinical Neurology

Conservative iron chelation for neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis

David Devos et al.

JOURNAL OF NEURAL TRANSMISSION (2020)

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Review Biochemistry & Molecular Biology

Ferritin Nanocages for Protein Delivery to Tumor Cells

Federica Palombarini et al.

MOLECULES (2020)

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Article Nanoscience & Nanotechnology

Dual-targeting nanoparticle vaccine elicits a therapeutic antibody response against chronic hepatitis B

Wenjun Wang et al.

NATURE NANOTECHNOLOGY (2020)

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Review Biotechnology & Applied Microbiology

The biomedical and bioengineering potential of protein nanocompartments

Aubrey M. Demchuk et al.

BIOTECHNOLOGY ADVANCES (2020)

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Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

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Article Immunology

A respiratory syncytial virus (RSV) F protein nanoparticle vaccine focuses antibody responses to a conserved neutralization domain

Kurt A. Swanson et al.

SCIENCE IMMUNOLOGY (2020)

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Article Chemistry, Analytical

16-Mer ferritin-like protein templated gold nanoclusters for bioimaging detection of methylmercury in the brain of living mice

Chenyan Lv et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Biophysics

Efficient synergistic combination effect of Quercetin with Curcumin on breast cancer cell apoptosis through their loading into Apo ferritin cavity

Fariba Mansourizadeh et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Biotechnology & Applied Microbiology

Recombinant ferritin nanoparticles can induce dendritic cell maturation through TLR4/NF-κB pathway

Zhehui Qu et al.

BIOTECHNOLOGY LETTERS (2020)

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Article Medicine, Research & Experimental

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation

Hannah G. Kelly et al.

JCI INSIGHT (2020)

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Review Biotechnology & Applied Microbiology

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective

Shokouh Attarilar et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

Baoshan Zhang et al.

SCIENTIFIC REPORTS (2020)

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Article Pharmacology & Pharmacy

Engineered Human Nanoferritin Bearing the Drug Genz-644282 for Cancer Therapy

Elisabetta Falvo et al.

PHARMACEUTICS (2020)

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A natural drug entry channel in the ferritin nanocage

Bing Jiang et al.

NANO TODAY (2020)

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Review Medicine, Research & Experimental

Ferritins as natural and artificial nanozymes for theranostics

Bing Jiang et al.

THERANOSTICS (2020)

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Article Engineering, Biomedical

Prussian blue-modified ferritin nanoparticles for effective tumor chemo-photothermal combination therapy via enhancing reactive oxygen species production

Hao Li et al.

JOURNAL OF BIOMATERIALS APPLICATIONS (2019)

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Article Chemistry, Physical

Detergent-modified catalytic and enzymomimetic activity of silver and palladium nanoparticles biotemplated by Pyrococcus furiosus ferritin

Marie Peskova et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Tao Wang et al.

NANO RESEARCH (2019)

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Nanozymes: From New Concepts, Mechanisms, and Standards to Applications

Minmin Liang et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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Singlet oxygen-activatable Paclitaxel prodrugs via intermolecular activation for combined PDT and chemotherapy

Moses Bio et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

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Multifunctional Ferritin Nanoparticles as Theranostics for Imaging-Guided Tumor Phototherapy

Jun Zhang et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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MRI Tracking of SPIO- and Fth1-Labeled Bone Marrow Mesenchymal Stromal Cell Transplantation for Treatment of Stroke

Xiaolei Huang et al.

CONTRAST MEDIA & MOLECULAR IMAGING (2019)

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Ferritin nanovehicle for targeted delivery of cytochrome C to cancer cells

Alberto Macone et al.

SCIENTIFIC REPORTS (2019)

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Novel Paclitaxel-Loaded Nanoparticles Based on Human H Chain Ferritin for Tumor-Targeted Delivery

Ruike Li et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2019)

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Article Clinical Neurology

Elevated serum ferritin level as a predictor of reduced survival in patients with sporadic amyotrophic lateral sclerosis in China: a retrospective study

Qionghua Sun et al.

AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2019)

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Article Materials Science, Biomaterials

Ferritin nanocage-based antigen delivery nanoplatforms: epitope engineering for peptide vaccine design

Zhantong Wang et al.

BIOMATERIALS SCIENCE (2019)

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Article Medicine, Research & Experimental

GRP78-targeted ferritin nanocaged ultra-high dose of doxorubicin for hepatocellular carcinoma therapy

Bing Jiang et al.

THERANOSTICS (2019)

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Article Chemistry, Inorganic & Nuclear

Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase

Martina Hestericova et al.

DALTON TRANSACTIONS (2018)

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Twenty years of terahertz imaging [Invited]

Daniel M. Mittleman

OPTICS EXPRESS (2018)

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Kelong Fan et al.

NATURE COMMUNICATIONS (2018)

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Article Materials Science, Biomaterials

Dual-functional carbon dot-labeled heavy-chain ferritin for self-targeting bio-imaging and chemo-photodynamic therapy

Hanchun Yao et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Article Chemistry, Medicinal

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens

Ivelin S. Georgiev et al.

ACS INFECTIOUS DISEASES (2018)

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Review Nutrition & Dietetics

Impact of Inflammation on Ferritin, Hepcidin and the Management of Iron Deficiency Anemia in Chronic Kidney Disease

Norishi Ueda et al.

NUTRIENTS (2018)

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Review Food Science & Technology

Ferritin cage for encapsulation and delivery of bioactive nutrients: From structure, property to applications

Jiachen Zang et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

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Article Food Science & Technology

A Novel Approach to Prepare Protein-proanthocyanidins Nano-complexes by the Reversible Assembly of Ferritin Cage

Zhongkai Zhou et al.

FOOD SCIENCE AND TECHNOLOGY RESEARCH (2017)

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Article Agriculture, Multidisciplinary

Thermally Induced Encapsulation of Food Nutrients into Phytoferritin through the Flexible Channels without Additives

Rui Yang et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)

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Article Chemistry, Multidisciplinary

Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy

Yang Li et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Multidisciplinary Sciences

Protein nanocages that penetrate airway mucus and tumor tissue

Xinglu Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Biochemistry & Molecular Biology

H-Ferritin Enriches the Curcumin Uptake and Improves the Therapeutic Efficacy in Triple Negative Breast Cancer Cells

Laura Pandolfi et al.

BIOMACROMOLECULES (2017)

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Article Chemistry, Multidisciplinary

Biomineralization-Inspired Synthesis of Copper Sulfide-Ferritin Nanocages as Cancer Theranostics

Zhantong Wang et al.

ACS NANO (2016)

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Article Biochemistry & Molecular Biology

Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus α-toxin action

Gisela von Hoven et al.

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Ferritin-mediated siRNA delivery and gene silencing in human tumor and primary cells

Le Li et al.

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Delivery of Nanoparticles for Treatment of Brain Tumor

Chen Kang et al.

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Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

Masaru Kanekiyo et al.

CELL (2015)

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Folic acid conjugated ferritins as photosensitizer carriers for photodynamic therapy

Zipeng Zhen et al.

NANOSCALE (2015)

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An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib

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PLOS ONE (2015)

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Hepatocellular carcinoma: A comprehensive review

Lisa P. Waller et al.

WORLD JOURNAL OF HEPATOLOGY (2015)

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Review Pharmacology & Pharmacy

Ferritins as nanoplatforms for imaging and drug delivery

Zipeng Zhen et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

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Article Nanoscience & Nanotechnology

Ferritin Nanocages: A Novel Platform for Biomedical Applications

Bharat Bhushan et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014)

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Article Chemistry, Medicinal

In Vivo Long-Term Magnetic Resonance Imaging Activity of Ferritin-Based Magnetic Nanoparticles versus a Standard Contrast Agent

Elsa Valero et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

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Article Multidisciplinary Sciences

H-ferritin-nanocaged doxorubicin nanoparticles specifically target and kill tumors with a single-dose injection

Minmin Liang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Review Biochemistry & Molecular Biology

The significance of ferritin in cancer: Anti-oxidation, inflammation and tumorigenesis

Ahmed A. Alkhateeb et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)

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Article Multidisciplinary Sciences

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

Masaru Kanekiyo et al.

NATURE (2013)

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