期刊
ADVANCED MATERIALS
卷 28, 期 7, 页码 1387-1393出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201503893
关键词
iron oxide nanoparticles; neurodegeneration; oxidative stress; catalase mimics
类别
资金
- Science and Technology Service Network Initiative from Chinese Academy of Sciences [KFJ-EW-STS-099]
- Ministry of Science and Technology (973 Program) [2012CB825805, 2013CB933802, 2012CB932600]
- National Natural Science Foundation of China [21390414, 31322039, 31371493, U1332119, 31470970]
- Shanghai Municipal Commission for Science and Technology [13NM1402300]
Dietary iron oxide nanoparticles are shown to ameliorate neurodegeneration in a Drosophelia Alzheimer's disease model. Iron oxide nanoparticles can mimic catalase and can decompose reactive oxygen species (ROS). This has potential therapeutic uses for aging, metabolic disorders, and neurodegenerative diseases, in which increased production of ROS is closely implicated.
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