4.5 Article

Multimodal Imaging of Dental Pulp Healing Patterns Following Tooth Autotransplantation and Regenerative Endodontic Treatment

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Review Chemistry, Physical

Regeneration of the Pulp Tissue: Cell Homing versus Cell Transplantation Approach: A Systematic Review

Elisabeth Tirez et al.

Summary: This systematic review compares the apical healing, root maturation, and histological characteristics of teeth treated with cell-based and cell-free techniques. The available studies suggest that there is no significant difference in apical healing between the two techniques, but the results regarding tooth maturation are contradictory. The main difference seems to be the histology of the treated tooth, with the cell-free technique resulting in cementum-like, bone-like, or periodontal ligament-like tissue, while the cell-based technique leads to the regeneration of the whole pulp with various tissues. However, there is a lack of randomized clinical trials on this topic, and more long-term data are needed to evaluate the healing and reparative patterns of both techniques.

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