Pulmonary delivery of curcumin and quercetin nanoparticles for lung cancer-Part 2: Toxicity and endocytosis

Article Biochemistry & Molecular Biology

A Preliminary Study of the Effect of Quercetin on Cytotoxicity, Apoptosis, and Stress Responses in Glioblastoma Cell Lines

Magdalena Kusaczuk et al.

Summary: The study investigated the interaction of dietary flavonoid quercetin with human glioblastoma cell lines. The results showed that quercetin induced apoptosis and cell death through activation of the intrinsic pathway of apoptosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Pharmacology & Pharmacy

Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment

Kangkang Li et al.

Summary: Lung cancer is a major cause of cancer death globally, especially for non-small cell lung cancer (NSCLC). In this study, Que-loaded mixed micelles (Que-MMICs) were developed for NSCLC treatment, showing improved therapeutic efficacy and tumor targeting capability.

DRUG DELIVERY (2022)

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Article Food Science & Technology

Toxicity of curcumin nanoparticles towards alveolar macrophage: Effects of surface charges

Ching-Yee Loo et al.

Summary: This study evaluated the toxicity of Cur-NPs on alveolar macrophages and found that the toxicity is dependent on the surface charge of the nanoparticles. Positively charged Cur-NPs showed the strongest toxicity, while neutral Cur-NPs entered cells through different uptake pathways.

FOOD AND CHEMICAL TOXICOLOGY (2022)

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Article Nanoscience & Nanotechnology

GA&HA-Modified Liposomes for Co-Delivery of Aprepitant and Curcumin to Inhibit Drug-Resistance and Metastasis of Hepatocellular Carcinoma

Yanying Li et al.

Summary: The combination therapy based on HA&GA-LPs shows promising effects in inhibiting the growth and metastasis of hepatocellular carcinoma, as well as reducing extracellular matrix deposition and tumor angiogenesis.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2022)

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Article Pharmacology & Pharmacy

PLGA-Quercetin Nano-Formulation Inhibits Cancer Progression via Mitochondrial Dependent Caspase-3,7 and Independent FoxO1 Activation with Concomitant PI3K/AKT Suppression

Neera Yadav et al.

Summary: This study demonstrates the potential of PLGA-QNPs in anticancer therapy. PLGA-QNPs significantly reduce the viability of cervical and breast cancer cells, induce apoptosis, and suppress cancer progression through regulation of gene expression and signaling pathways. In a mammary adenocarcinoma rat model, PLGA-QNPs also reduce tumor burden and prolong tumor latency. Therefore, PLGA-QNPs may serve as an effective drug delivery system for anticancer therapy.

PHARMACEUTICS (2022)

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Review Biochemistry & Molecular Biology

A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells

Partha Biswas et al.

Summary: Reactive oxygen species (ROS) play a critical role in carcinogenesis by affecting cell proliferation, survival, and apoptosis through genetic mutations, activation of oncogenes, and increased oxidative stress. Quercetin, a plant-derived bioflavonoid, has been found to scavenge ROS and exhibit anti-tumor properties, particularly in solid tumors. The unique feature of cancer cells, having higher levels of ROS, makes them susceptible to quercetin. Targeting ROS metabolism in cancer cells while sparing normal cells could be a promising approach in cancer therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Curcumin-Based Nanoformulations: A Promising Adjuvant towards Cancer Treatment

Salar Hafez Ghoran et al.

Summary: Cancer remains the second leading cause of death in the United States, with traditional treatments causing significant adverse effects, prompting the search for more effective anti-tumor medications. The use of nanocurcumin for cancer treatment is gaining interest, but there are still many issues that need to be addressed.

MOLECULES (2022)

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Review Pharmacology & Pharmacy

Role of Nrf2, STAT3, and Src as Molecular Targets for Cancer Chemoprevention

Haseeb Ahsan et al.

Summary: Cancer is a complex disease that can be prevented or suppressed through chemoprevention. Targeting molecules such as Nrf2, STAT3, and Src, which are involved in various pathways of cancer, can reduce oxidative stress and inflammation and stop cancer initiation and progression.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Curcumin-Encapsulated Nanomicelles Improve Cellular Uptake and Cytotoxicity in Cisplatin-Resistant Human Oral Cancer Cells

Vijay M. Kumbar et al.

Summary: Oral cancer has a high mortality rate and chemotherapy is the preferred treatment, but drug resistance limits its effectiveness. This study found that curcumin nanomicelles can improve the therapeutic effects of curcumin in treating cisplatin-resistant oral cancer.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

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Article Oncology

Synergistic Effect of Quercetin Magnetite Nanoparticles and Targeted Radiotherapy in Treatment of Breast Cancer

Mostafa A. Askar et al.

Summary: Quercetin-conjugated magnetite nanoparticles (QMNPs) were successfully prepared using a biological simple nanoprecipitation approach mediated by fungus Aspergillus oryzae. In vitro studies demonstrated the inhibitory effects of QMNPs on MCF-7, HePG-2, and A459 cancer cell lines, while in vivo experiments showed their potential to sensitize breast cancer to radiotherapy. The combination of QMNPs with irradiation effectively blocked cancer cell proliferation and enhanced the therapeutic outcome in a rat model of breast cancer induced by N-methyl-N-nitrosourea, suggesting the potential of QMNPs as a targeted therapy in breast cancer.

BREAST CANCER-BASIC AND CLINICAL RESEARCH (2022)

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Review Materials Science, Multidisciplinary

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Faisal Raza et al.

Summary: The review emphasizes the importance of paclitaxel in cancer treatment, and discusses its application in the field of nanomedicine for cancer treatment. Additionally, various forms of nanomedicine of paclitaxel and future challenges are also discussed.

MATERIALS ADVANCES (2022)

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Article Oncology

Synergistic Induction of Apoptosis by Quercetin and Curcumin in Chronic Myeloid Leukemia (K562) Cells: II. Signal Transduction Pathways Involved

Ergul Mutlu Altundag et al.

Summary: Flavonoids have chemo-preventive and chemotherapeutic properties, with quercetin and curcumin showing beneficial synergistic effects on human cancer cells, specifically chronic myeloid leukemia cells through various signaling pathways.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Article Pharmacology & Pharmacy

Development and Evaluation of Paclitaxel and Curcumin Dry Powder for Inhalation Lung Cancer Treatment

Wing-Hin Lee et al.

Summary: This study aimed to develop a simple dry powder inhalation (DPI) formulation containing paclitaxel (PTX) and curcumin (CUR) to achieve preferential cytotoxicity towards lung cancer cells.

PHARMACEUTICS (2021)

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Review Cell Biology

Paclitaxel: Application in Modern Oncology and Nanomedicine-Based Cancer Therapy

Javad Sharifi-Rad et al.

Summary: Paclitaxel, derived from the bark of the yew tree, is a broad-spectrum anticancer compound used in the treatment of various cancers. Limited solubility and toxicity issues have led to the exploration of nanotechnology and nanoparticles for increased drug half-life, reduced toxicity, and targeted delivery.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Biotechnology & Applied Microbiology

Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

Enping Chen et al.

Summary: The study developed a mitochondria-directed pH-sensitive PVA nanogel that combined hexokinase inhibitor and chemotherapeutic drug, enhancing drug loading capacity, promoting drug release, and achieving mitochondrial targeting within cells, leading to significant anti-tumor effects.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Food Science & Technology

Intracellular quercetin accumulation and its impact on mitochondrial dysfunction in intestinal Caco-2 cells

Hanne Vissenaekens et al.

Summary: The study demonstrates that quercetin can partially restore mitochondrial dysfunction, especially FCCP-induced dysfunction, in intestinal cells by accumulating in the mitochondria.

FOOD RESEARCH INTERNATIONAL (2021)

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Review Cell Biology

Targeting Mitochondrial Biogenesis with Polyphenol Compounds

Leila Chodari et al.

Summary: Appropriate mitochondrial physiology is crucial for health and survival, with polyphenols being considered effective components for treating various diseases by regulating mitochondrial biogenesis pathways.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Oncology

Preparation of cerium-curcumin and cerium-quercetin complexes and their LEDs irradiation assisted anticancer effects on MDA-MB-231 and A375 cancer cell lines

Reza Hosseinzadeh et al.

Summary: Curcumin and quercetin in complex with cerium ions show improved toxic effect against breast and melanoma cancer cells under red or blue light irradiation, potentially serving as a novel approach in photodynamic treatment.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2021)

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Review Oncology

Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health

Rafiq A. Rather et al.

CANCER MEDICINE (2020)

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Article Chemistry, Medicinal

Delivery of pDNA to lung epithelial cells using PLGA nanoparticles formulated with a cell-penetrating peptide: understanding the intracellular fate

Larissa Gomes dos Reis et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2020)

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Review Medicine, General & Internal

Biphasic Dose-Response Induced by Phytochemicals: Experimental Evidence

Jadwiga Jodynis-Liebert et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Article Multidisciplinary Sciences

Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer

Rui Li et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemistry & Molecular Biology

Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes

Elham Ahmadian et al.

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY (2020)

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Article Biophysics

Efficient synergistic combination effect of Quercetin with Curcumin on breast cancer cell apoptosis through their loading into Apo ferritin cavity

Fariba Mansourizadeh et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Article Pharmacology & Pharmacy

Comparative anti-inflammatory effect of curcumin at air-liquid interface and submerged conditions using lipopolysaccharide stimulated human lung epithelial A549 cells

Yue Hu et al.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2020)

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Article Biochemistry & Molecular Biology

Methanolic extract of Artemisia absinthium prompts apoptosis, enhancing expression of Bax/Bcl-2 ratio, cell cycle arrest, caspase-3 activation and mitochondrial membrane potential destruction in human colorectal cancer HCT-116 cells

Mehri Nazeri et al.

MOLECULAR BIOLOGY REPORTS (2020)

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Article Oncology

Curcumin exerts cytotoxicity dependent on reactive oxygen species accumulation in non-small-cell lung cancer cells

Cuijuan Wang et al.

FUTURE ONCOLOGY (2019)

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Review Nanoscience & Nanotechnology

Boosting Cancer Therapy with Organelle-Targeted Nanomaterials

Peng Gao et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Review Biochemistry & Molecular Biology

Mechanism of Apoptosis Induced by Curcumin in Colorectal Cancer

Nor Isnida Ismail et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Medicine, General & Internal

Effects of Quercetin-Loaded Nanoparticles on MCF-7 Human Breast Cancer Cells

Firoozeh Niazvand et al.

MEDICINA-LITHUANIA (2019)

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Article Pathology

Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells

Faezeh Ghasemi et al.

PATHOLOGY RESEARCH AND PRACTICE (2019)

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Review Reproductive Biology

Quercetin: a natural compound for ovarian cancer treatment

Rana Shafabakhsh et al.

JOURNAL OF OVARIAN RESEARCH (2019)

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Article Oncology

ROS as a novel indicator to predict anticancer drug efficacy

Tarek Zaidieh et al.

BMC CANCER (2019)

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Review Cell Biology

Hormetic effects of curcumin: What is the evidence?

Nazanin Sadat Aghili Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Cell Biology

Synergistic anticancer action of quercetin and curcumin against triple-negative breast cancer cell lines

Sai Kundur et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Nanoscience & Nanotechnology

Co-Delivery of Curcumin and Paclitaxel by Core-Shell Targeting Amphiphilic Copolymer to Reverse Resistance in the Treatment of Ovarian Cancer

Meng-Dan Zhao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Oncology

Curcumin induces a fatal energetic impairment in tumor cells in vitro and in vivo by inhibiting Q ATP-synthase activity

Giovanna Bianchi et al.

CARCINOGENESIS (2018)

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Article Multidisciplinary Sciences

Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth

Yonika Arum Larasati et al.

SCIENTIFIC REPORTS (2018)

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Article Oncology

IL-6 and TNF-α promote metastasis of lung cancer by inducing epithelial-mesenchymal transition

Guan-Sheng Shang et al.

ONCOLOGY LETTERS (2017)

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Article Biochemistry & Molecular Biology

Intricatinol synergistically enhances the anticancerous activity of cisplatin in human A549 cells via p38 MAPK/p53 signalling

Vipendra Kumar Singh et al.

APOPTOSIS (2017)

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Article Pharmacology & Pharmacy

Curcumin: a calixarene derivative micelle potentiates anti-breast cancer stem cells effects in xenografted, triple-negative breast cancer mouse models

Wei Chen et al.

DRUG DELIVERY (2017)

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Article Chemistry, Multidisciplinary

Curcumin Nanoparticles Attenuate Production of Pro-inflammatory Markers in Lipopolysaccharide-Induced Macrophages

Wing-Hin Lee et al.

PHARMACEUTICAL RESEARCH (2016)

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Article Nanoscience & Nanotechnology

Synthesis and Characterization of Inhalable Flavonoid Nanoparticle for Lung Cancer Cell Targeting

Wing-Hin Lee et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2016)

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Article Oncology

IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib

Romaine I. Fernando et al.

ONCOTARGET (2016)

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Article Oncology

Erlotinib induces the human non-small-cell lung cancer cells apoptosis via activating ROS-dependent JNK pathways

Fenglian Shan et al.

CANCER MEDICINE (2016)

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Article Multidisciplinary Sciences

Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling Pathway

Xiang Li et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Quercetin, a Natural Flavonoid Interacts with DNA, Arrests Cell Cycle and Causes Tumor Regression by Activating Mitochondrial Pathway of Apoptosis

Shikha Srivastava et al.

SCIENTIFIC REPORTS (2016)

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Review Oncology

Relationship and interactions of curcumin with radiation therapy

Vivek Verma

WORLD JOURNAL OF CLINICAL ONCOLOGY (2016)

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Article Nanoscience & Nanotechnology

Fabrication of Curcumin Micellar Nanoparticles with Enhanced Anti-Cancer Activity

Wing-Hin Lee et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

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Article Chemistry, Physical

Clathrin to Lipid Raft-Endocytosis via Controlled Surface Chemistry and Efficient Perinuclear Targeting of Nanoparticle

Atanu Chakraborty et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2015)

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Review Biochemistry & Molecular Biology

The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

Muthu K. Shanmugam et al.

MOLECULES (2015)

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Editorial Material Cell Biology

Curcumin hormesis mediates a cross-talk between autophagy and cell death

N. Rainey et al.

CELL DEATH & DISEASE (2015)

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Review Pharmacology & Pharmacy

Recent advances in curcumin nanoformulation for cancer therapy

Wing-Hin Lee et al.

EXPERT OPINION ON DRUG DELIVERY (2014)

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Review Biochemistry & Molecular Biology

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

Kavirayani Indira Priyadarsini

MOLECULES (2014)

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Article Oncology

Regulation of Wnt signaling activity for growth suppression induced by quercetin in 4T1 murine mammary cancer cells

Haesung Kim et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2013)

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Article Pharmacology & Pharmacy

Toxicity of surface-modified PLGA nanoparticles toward lung alveolar epithelial cells

Nadege Grabowski et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Toxicology

Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin

Bin Sun et al.

TOXICOLOGY IN VITRO (2013)

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Article Oncology

Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia

Robert E. Carroll et al.

CANCER PREVENTION RESEARCH (2011)

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Article Engineering, Chemical

Solubility and solution thermodynamic properties of quercetin and quercetin dihydrate in subcritical water

Keerthi Srinivas et al.

JOURNAL OF FOOD ENGINEERING (2010)

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Review Nutrition & Dietetics

Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management

Ashley J. Vargas et al.

NUTRITION REVIEWS (2010)

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Article Oncology

Interfering with ROS Metabolism in Cancer Cells: The Potential Role of Quercetin

Lara Gibellini et al.

Cancers (2010)

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Article Nutrition & Dietetics

Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2)

Ana Belen Granado-Serrano et al.

JOURNAL OF NUTRITION (2006)

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Review Respiratory System

Oxidative stress and redox regulation of lung inflammation in COPD

I. Rahman et al.

EUROPEAN RESPIRATORY JOURNAL (2006)

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Pulmonary delivery of curcumin and quercetin nanoparticles for lung cancer-Part 2: Toxicity and endocytosis

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