期刊
JOURNAL OF DERMATOLOGICAL TREATMENT
卷 34, 期 1, 页码 -出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2023.2183729
关键词
Psoriasis; atopic dermatitis; upadacitinib
类别
This study reports the cases of four patients with overlapping features of both psoriasis and atopic dermatitis (AD). After being treated with several systemic drugs, including gold-standard treatments for both psoriasis and AD, they received upadacitinib 15 or 30 mg, achieving complete remission. Conclusion: To date, very limited data are available regarding the efficacy of upadacitinib in psoriasis.
Purpose: The overlap of psoriasis and atopic dermatitis (AD) is rare and treating moderate-to-severe cases can be challenging. Conventional immune-suppressive drugs cannot be used long-term, and no biological drugs are currently approved for treating both conditions. Method: We report the cases of four patients with overlapping features of both psoriasis and AD. Result: After being treated with several systemic drugs, including gold-standard treatments for both psoriasis and AD, they received upadacitinib 15 or 30 mg, achieving complete remission. Upadacitinib is an inhibitor of Janus Kinase 1, currently approved for treating moderate-to-severe AD. Conclusion: To date, very limited data are available regarding the efficacy of upadacitinib in psoriasis. In a phase-3 trial on the efficacy of upadacitinib 15 mg in patients affected by psoriatic arthritis, 52.3% of patients achieved a 75% improvement in Psoriasis Area and Severity Index (PASI75) after one year. Currently, no clinical trials are evaluating the efficacy of upadacitinib in plaque psoriasis.
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