☆ 4.8 Review

Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions

JOURNAL OF CONTROLLED RELEASE (2023)

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Review Nanoscience & Nanotechnology

Recent Trend of Ultrasound-Mediated Nanoparticle Delivery for Brain Imaging and Treatment

SeongHoon Jo et al.

Summary: The blood-brain barrier poses a challenge to the delivery of imaging probes and therapeutic agents to the brain. Methods like ultrasound-mediated nano-particle delivery and photoacoustic brain imaging have emerged as potential solutions. Focused ultrasound is a popular means of enhancing drug delivery through temporary opening of the blood-brain barrier, while photoacoustic brain imaging uses light-to-heat conversion and ultrasound detection to visualize brain morphologies or diseases. The versatility of nanoparticles allows for successful brain imaging and treatment through the combined action of ultrasound and nanoparticulate agents.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Mechanics

Targeted nano-sized drug delivery to heterogeneous solid tumor microvasculatures: Implications for immunoliposomes exhibiting bystander killing effect

Mohammad Amin Abazari et al.

Summary: This study developed a computational framework to evaluate the treatment efficacy of free Doxorubicin (Dox) and immunoliposome at different stages of vascular solid tumors. The results showed that immunoliposomes exhibited higher drug internalization and fusion effect during therapy, leading to more homogeneous drug distribution and a greater fraction of killed cancer cells.

PHYSICS OF FLUIDS (2023)

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Article Oncology

Multiphysics Modeling of Low-Intensity Pulsed Ultrasound Induced Chemotherapeutic Drug Release from the Surface of Gold Nanoparticles

Tyler K. Hornsby et al.

Summary: Ultrasound can induce the release of anticancer drugs from nanoparticle drug carriers, as observed in previous studies. This study applies the DLVO theory to predict the release of doxorubicin from gold nanoparticle drug carriers under low-intensity pulsed ultrasound exposure. The findings contribute to understanding the mechanism of ultrasound-induced drug release from nanoparticles.

CANCERS (2023)

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Article Acoustics

A Quantitative Study of Thermal and Non-thermal Mechanisms in Ultrasound-Induced Nano-drug Delivery

Tyler K. Hornsby et al.

Summary: The main aim of this study was to quantify the contributions of thermal and non-thermal mechanisms to drug release in ultrasound-induced release from gold nanoparticles (GNPs). Drug release from the surface of GNPs was induced using two different methods in an ex vivo tissue model: localized tissue heating with a water bath and low-intensity pulsed ultrasound (LIPUS) exposure. It was found that LIPUS exposure, which combines thermal and non-thermal mechanisms, resulted in a higher drug release compared to water bath heating, which only uses thermal mechanisms.

ULTRASOUND IN MEDICINE AND BIOLOGY (2023)

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Review Chemistry, Multidisciplinary

Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

Mohammad Souri et al.

Summary: Nanocarriers have been widely studied for anticancer drug delivery, with their clinical translation facing challenges due to inefficient accumulation and penetration in tumor microenvironment. Despite various strategies proposed to overcome these challenges, their success has been limited so far. Novel strategies such as transformable nanocarriers and transcellular transport of peptide-modified nanocarriers have emerged as potential advanced drug delivery systems.

JOURNAL OF CONTROLLED RELEASE (2022)

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Review Oncology

Latest Advances in the Use of Therapeutic Focused Ultrasound in the Treatment of Pancreatic Cancer

Petros X. E. Mouratidis et al.

Summary: Pancreatic cancer, with its low survival rates, presents a significant challenge in terms of treatment. Immunotherapy has shown promise in cancer treatment, but its effectiveness for pancreatic cancer patients is limited. Alternative treatment approaches to enhance the effectiveness of immunotherapy are needed. Therapeutic focused ultrasound, a non-invasive physical modality, can kill cancer cells and induce an anti-cancer immune response. Studies have shown that therapeutic focused ultrasound is a safe and effective technique for treating pancreatic cancer patients, improving survival rates.

CANCERS (2022)

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Article Pharmacology & Pharmacy

Computational Modeling of Combination of Magnetic Hyperthermia and Temperature-Sensitive Liposome for Controlled Drug Release in Solid Tumor

Masoud H. H. Tehrani et al.

Summary: This study investigates the potential of combination therapy using thermo-sensitive liposomes loaded with doxorubicin (TSL-Dox) during magnetic hyperthermia (MHT) for cancer treatment. The results show that this combination therapy significantly increases the killing rate and fraction of killed cells (FKCs) inside the tumor compared to conventional chemotherapy, while reducing side effects. The study also explores the impact of various factors on treatment efficacy and suggests that the administration of MHT can improve the TSL delivery system.

PHARMACEUTICS (2022)

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Article Engineering, Biomedical

Towards principled design of cancer nanomedicine to accelerate clinical translation

Mohammad Souri et al.

Summary: Nanotechnology has shown promising results in medical applications, particularly in oncology as drug delivery systems. However, the clinical translation of this technology is challenging. To optimize drug delivery systems for clinical translation, the physicochemical characteristics of nanoparticles can be specified. Researchers have focused on producing biocompatible materials, production technologies, or new formulations to improve efficiency and stability. The effects of design parameters can be studied using various methods. This review summarizes the advances and technologies in cancer nanomedicines for clinical translation and commercialization, as well as the existing challenges and opportunities in the field.

MATERIALS TODAY BIO (2022)

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Review Neurosciences

Current State of Potential Mechanisms Supporting Low Intensity Focused Ultrasound for Neuromodulation

John Dell'Italia et al.

Summary: Low intensity focused ultrasound (LIFU) has been recognized as a non-invasive neuromodulation technology with superior spatial specificity. This review introduces the underlying mechanics of acoustic energy and neuronal membranes, as well as categorizes empirical studies to evaluate theoretical mechanisms supporting LIFU's effects.

FRONTIERS IN HUMAN NEUROSCIENCE (2022)

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Review Oncology

Focused ultrasound for the treatment of glioblastoma

Jill W. Roberts et al.

Summary: This article reviews the key updates from the 2021 workshop on focused ultrasound in the treatment of glioblastoma, outlines next research steps, and provides relevant references.

JOURNAL OF NEURO-ONCOLOGY (2022)

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Article Biotechnology & Applied Microbiology

Drug delivery through nanoparticles in solid tumors: a mechanistic understanding

Farshad Moradi Kashkooli et al.

Summary: The aim of this study was to apply a multi-scale computational model to evaluate the use of nano-sized drug-delivery systems in predicting treatment efficacy in solid tumors. The study found that smaller nanoparticles or low binding affinity and drug release rate can achieve higher treatment efficacy.

NANOMEDICINE (2022)

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Article Chemistry, Multidisciplinary

Analysis of Magneto-Hyperthermia Duration in Nano-sized Drug Delivery System to Solid Tumors Using Intravascular-Triggered Thermosensitive-Liposome

Mohammad Souri et al.

Summary: A mathematical model was used to investigate the therapeutic response of drug-loaded thermosensitive liposome following intravascular release. The study found that continuous or pulsed hyperthermia can affect drug concentration levels, with a slightly higher concentration for pulsed mode. However, there was no significant difference in onset time of tumor growth.

PHARMACEUTICAL RESEARCH (2022)

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Article Biotechnology & Applied Microbiology

Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system

Nour M. AlSawaftah et al.

Summary: Targeted liposomes deliver chemotherapeutics to tumours and reduce systemic side effects. Low-frequency ultrasound can trigger drug release from liposomes, and targeted liposomes are more susceptible to ultrasound. Targeting also enhances cellular uptake of the drug and is further enhanced by ultrasound.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Ultrasound and nanomaterial: an efficient pair to fight cancer

Edouard Alphandery

Summary: Ultrasound combined with nano-systems shows great potential in improving cancer treatment by enhancing ultrasound imaging, specific tumor targeting, and more moderate tumor heating. These combined treatments can potentially improve the benefit/risk ratio of current cancer treatments.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Review Pharmacology & Pharmacy

Thermosensitive liposomes: a promising step toward localised chemotherapy

Maryam Chaudhry et al.

Summary: This article evaluates the progress of thermolabile drug carrier systems in pre-clinical and clinical settings, as well as the modalities used to trigger drug release. The combined application of mild hyperthermia and heat-responsive liposomal drug carriers shows great potential utility, and ongoing clinical trials aim to refine this approach for optimal patient benefit.

EXPERT OPINION ON DRUG DELIVERY (2022)

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Article Chemistry, Multidisciplinary

Steric Effects in the Deposition Mode and Drug-Delivering Efficiency of Nanocapsule-Based Multilayer Films

Li Xu et al.

Summary: In this study, block polymers with different quaternization degrees were successfully coated on the surface of silica nanocapsules using surface-initiated atom transfer radical polymerization (ATRP), and the antiviral drug Molnupiravir was encapsulated in the polymer-coated nanocapsules. The encapsulated drugs were further incorporated into well-defined films by layer-by-layer (LBL) self-assembly. The researchers investigated the effect of polymer quaternization degree and steric hindrance of functional groups on the growth mode, swelling/deswelling transition, and drug-delivering efficiency of the films.

ACS OMEGA (2022)

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Review Pharmacology & Pharmacy

Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

Yixuan Zi et al.

Summary: The article provides an overview of approaches for evaluating the Enhanced Permeability and Retention (EPR) effect in human tumors and discusses strategies for utilizing the EPR effect in cancer treatment. The article also highlights recent developments in alternative tumor-targeted delivery mechanisms and introduces preclinical models that better reflect human tumors. Additionally, the article suggests more rational applications of the EPR effect in other diseases and fields.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Biology

Drug transport kinetics of intravascular triggered drug delivery systems

Timo L. M. ten Hagen et al.

Summary: The study developed a computational model to simulate Intravascular Triggered Drug Delivery Systems (IV-DDS) for local drug delivery and validated the model through experiments. The model explained delivery kinetics, identified optimal delivery parameters, and highlighted key factors affecting drug delivery. It also demonstrated the importance of fast drug release and rapid tissue uptake for efficient delivery.

COMMUNICATIONS BIOLOGY (2021)

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Review Clinical Neurology

Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Ying Meng et al.

Summary: Focused ultrasound (FUS) is a disruptive medical technology that can precisely intervene in key circuits of brain disorders, with various forms of actions such as blood-brain barrier opening and neuromodulation. In recent years, there has been a significant expansion of FUS applications in humans, leading to increased academic and public interest in the technology.

NATURE REVIEWS NEUROLOGY (2021)

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Article Chemistry, Multidisciplinary

Nanotechnology for a Sustainable Future: Addressing Global Challenges with the International Network4Sustainable Nanotechnology

Lisa Pokrajac et al.

Summary: In summary, nanotechnology can contribute to the achievement of Sustainable Development Goals through technological innovation and interdisciplinary approaches, accelerating progress both in individual countries and globally. Various nations are actively working towards these goals by targeting solutions, technology translation, and promoting a circular economy.

ACS NANO (2021)

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Article Chemistry, Physical

pH and ultrasound dual-responsive drug delivery system based on PEG-folate-functionalized Iron-based metal-organic framework for targeted doxorubicin delivery

Ahmed Ahmed et al.

Summary: This study synthesized dual-responsive iron-based MOFs and successfully loaded the anticancer drug DOX into them, demonstrating good colloidal stability with PEG-FA functionalized MOFs. The research confirmed the sensitivity of the nanovehicles to low-frequency ultrasound and showed their release efficiency under different pH values.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Review Nanoscience & Nanotechnology

Engineered Nanomaterials: The Challenges and Opportunities for Nanomedicines

Fahad Albalawi et al.

Summary: The emergence of nanotechnology as a key enabling technology has opened avenues for new and innovative applications in nanomedicine. Despite the potential of the nanomedicine market, challenges in evaluating the toxicity of engineered nanomaterials present significant obstacles in bringing them into clinical stages.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Materials Science, Biomaterials

A theoretical and experimental study on L-tyrosine and citrate mediated sustainable production of near infrared absorbing twisted gold nanorods

Anshuman Jakhmola et al.

Summary: An efficient and sustainable one-pot protocol was developed to fabricate twisted gold nanorods, a unique anisotropic shape displaying a broad plasmon band extending into the near infrared-III range. The growth mechanism was directed by L-tyrosine and trisodium citrate, with a diffusion limited aggregation numerical scheme used to describe the process accurately. The resulting structure was thoroughly characterized in terms of morphology, with demonstrated SERS and cytotoxic activity.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Chemistry, Multidisciplinary

Toward Precisely Controllable Acoustic Response of Shell-Stabilized Nanobubbles: High Yield and Narrow Dispersity

Amin Jafari Sojahrood et al.

Summary: Understanding the pressure dependence of the nonlinear behavior of ultrasonically excited phospholipid-stabilized nanobubbles (NBs) is crucial for optimizing ultrasound exposure parameters for contrast enhanced ultrasound. The viscoelastic properties of the shell, affected by membrane additives, influence the acoustic response of NBs. By controlling the size and shell structure, the interaction between shell components and the phospholipid membrane can be studied, offering insights for engineering ultrasound contrast agents.

ACS NANO (2021)

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Review Pharmacology & Pharmacy

Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery

J. Deprez et al.

Summary: Ultrasound, in addition to its clinical imaging application, has been extensively explored as a tool to enhance drug delivery. Therapeutic ultrasound can permeabilize biological barriers, enabling drugs to reach otherwise impermeable tissues and offering a new approach for drug delivery.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Acoustics

Development of an ultrasonic nonlinear frequency compounding method with applications in tissue thermometry

Tyler Hornsby et al.

Summary: This study introduced a nonlinear frequency compounding (NLFC) method and investigated its application in noninvasive tissue thermometry. The research found that the NLFC method can produce temperature maps with superior image SNR compared to the previously used nonlinear single frequency (NLSF) method.

JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA (2021)

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Article Oncology

Selecting the optimal parameters for sonoporation of pancreatic cancer in a pre-clinical model

Christopher W. Schultz et al.

Summary: The study showed that high power ultrasound treatment combined with Sonazoid sonoporation significantly reduced tumor volume and increased vascularity characteristics in PDAC. Sonazoid was the most consistently effective ultrasound contrast agent, especially when treatment began early.

CANCER BIOLOGY & THERAPY (2021)

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Article Acoustics

Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors

Mercy Afadzi et al.

Summary: Acoustic radiation force (ARF) induced by focused ultrasound (FUS) can enhance the interstitial transport of nanoparticles (NPs) in tumor tissues, improving their distribution within the tumor.

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2021)

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Article Acoustics

Effect of Acoustic Radiation Force on Displacement of Nanoparticles in Collagen Gels

Mia Kvale Lovmo et al.

Summary: This study investigated the effects of acoustic radiation force (ARF) on the penetration of nanoparticles (NPs) and deformation of collagen gels used as a model for tumor extracellular matrix. The experimental results showed that ARF did not affect the penetration of NPs into the collagen gels, but caused substantial deformation. Both experimental and theoretical results were consistent in terms of NP penetration and gel deformation.

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2021)

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Article Chemistry, Multidisciplinary

Transport of nanoparticles across the endothelial cell layer

Tore Skotland et al.

Summary: Despite more than three decades of research on how nanoparticles enter and are taken up by tumor cells, there is still much to learn about their interactions and transport mechanisms across the endothelial cell layer. More studies are needed before firm conclusions can be drawn regarding the passive or energy dependent mechanisms for nanoparticle transport to solid tumors.

NANO TODAY (2021)

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Article Acoustics

SONOPERMEATION ENHANCES UPTAKE AND THERAPEUTIC EFFECT OF FREE AND ENCAPSULATED CABAZITAXEL

Sofie Snipstad et al.

Summary: Combining microbubbles with ultrasound improves drug delivery to tumors, reducing tumor growth and extending survival in experimental models. Enhanced nanoparticle uptake following ultrasound treatment underscores the need for further understanding of tumor biology and ultrasound-mediated treatment mechanisms.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Article Multidisciplinary Sciences

Evaluation of solid tumor response to sequential treatment cycles via a new computational hybrid approach

Farshad Moradi Kashkooli et al.

Summary: The development of an in silico approach for evaluating personalized treatment protocols in cancer patients shows promising results in reducing tumor cells and improving treatment efficacy. By considering tumor geometry, drug delivery, and chemotherapy efficacy, the study introduces a novel sequential treatment approach that can potentially enhance cancer patient lifespans.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Effects of hypoxia and nanocarrier size on pH-responsive nano-delivery system to solid tumors

M. Soltani et al.

Summary: A comprehensive mathematical model is proposed in this study to investigate the impact of pH-responsive nanocarriers on cancer cell death, where smaller nanocarriers are more effective and capable of deeper penetration into tumor tissues, although the presence of hypoxic regions in tumors reduces drug penetration depth.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Computational modeling of thermal combination therapies by magneto-ultrasonic heating to enhance drug delivery to solid tumors

Mohammad Souri et al.

Summary: This study investigates the performance of Doxorubicin and its encapsulation using magnetic resonance imaging-guided high intensity focused ultrasound technology. The combination of thermal ablation and medication therapy shows improved therapeutic outcomes by stimulating biological properties. It is recommended to use thermal ablation before thermo chemotherapy and ThermoDox therapy due to the low drug penetration in the tumor center.

SCIENTIFIC REPORTS (2021)

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Article Biophysics

In vitro evaluation of polymeric nanoparticles with a fluorine core for drug delivery triggered by focused ultrasound

L. Somaglino et al.

Summary: Polymeric nanoparticles are being studied as potential drug carriers, and their drug release can be enhanced by triggering with ultrasound. However, the release is only significantly increased in the presence of detectable inertial cavitation.

COLLOIDS AND SURFACES B-BIOINTERFACES (2021)

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Review Chemistry, Physical

Bursting microbubbles: How nanobubble contrast agents can enable the future of medical ultrasound molecular imaging and image-guided therapy

Agata A. Exner et al.

Summary: The field of medical ultrasound has seen significant developments with the use of microbubbles as contrast agents. However, the limitations in their clinical applications due to size have led to the exploration of nanobubbles. This review discusses the potential of nanobubbles as imaging agents and therapeutic vehicles, with the aim of shaping the future of medical ultrasound.

CURRENT OPINION IN COLLOID & INTERFACE SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Temperature-Responsive Multilayer Films Based on Block Copolymer-Coated Silica Nanoparticles for Long-Term Release of Favipiravir

Li Xu et al.

Summary: By utilizing surface-initiated atom-transfer radical polymerization, temperature-responsive block polymers were functionalized on the surface of silica nanocapsules, demonstrating swelling/deswelling behaviors under temperature stimulus. The impact of steric hindrance on the assembling behavior, swelling/deswelling transition, and drug release rate of multilayer films was investigated.

ACS APPLIED NANO MATERIALS (2021)

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Article Multidisciplinary Sciences

Ultrasound-triggered herceptin liposomes for breast cancer therapy

Amal Elamir et al.

Summary: Functionalizing liposomes with monoclonal antibodies, particularly anti-HER2 antibodies, can enhance targeted drug delivery to HER2 positive breast cancer cells. Low frequency ultrasound (LFUS) triggered drug release from liposomes can be further enhanced by the conjugation of Trastuzumab, increasing drug uptake and cellular toxicity in HER2+ cell lines. Combining immunoliposomes with LFUS is a promising technique to improve drug delivery efficiency and reduce cytotoxicity of antineoplastic drugs.

SCIENTIFIC REPORTS (2021)

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Article Instruments & Instrumentation

Ultrasound-responsive polymer-based drug delivery systems

Ping Wei et al.

Summary: Ultrasound-responsive polymeric materials have shown great potential for efficient drug delivery and targeted treatment in various biomedical applications, including tumor therapy and disruption of the blood-brain barrier. Future research directions for the development of these smart materials are also discussed to facilitate clinical translation.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2021)

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Review Oncology

Application of Animal Models in Cancer Research: Recent Progress and Future Prospects

Zhitao Li et al.

Summary: Animal models play a crucial role in cancer research, with various construction methods such as chemical induction, xenotransplantation, and gene programming. These models not only help to study the occurrence and development of cancer in depth but also aid in drug screening and gene therapy exploration.

CANCER MANAGEMENT AND RESEARCH (2021)

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Article Mechanics

Experimental and numerical evidence of intensified non-linearity at the microscale: The lipid coated acoustic bubble

A. J. Sojahrood et al.

Summary: The lipid coated bubble (LCB) oscillator is a highly interesting non-smooth oscillator with a wide range of applications, but the dynamics of LCB are not well understood due to the complex behavior of the coating intermingled with the nonlinear behavior of the bubble. Experimental observations show that this unique oscillator can exhibit chaotic oscillations and higher order subharmonics at excitation amplitudes considerably below those predicted by the uncoated oscillator.

PHYSICS OF FLUIDS (2021)

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Review Pharmacology & Pharmacy

Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment

Kristin Entzian et al.

Summary: The development of nanomedicines offers new possibilities to improve treatment outcomes, reduce toxicity, and enhance drug delivery efficiency. Ultrasound-triggered drug delivery by nanocarriers allows on-demand drug release at tumor tissue sites, providing high tissue specificity and penetration.

PHARMACEUTICS (2021)

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Review Nanoscience & Nanotechnology

Nanoparticles for Cancer Therapy: Current Progress and Challenges

Shreelaxmi Gavas et al.

Summary: Nanotechnology has revolutionized cancer diagnosis and treatment by overcoming limitations of traditional therapies and multidrug resistance. Nanoparticles, with their unique advantages, offer new perspectives for cancer treatment. However, challenges still exist in research and clinical translation of nanotherapeutics.

NANOSCALE RESEARCH LETTERS (2021)

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Article Cell Biology

Toxicology of Nanoparticles in Drug Delivery

Swati Sharma et al.

Summary: Nanoparticles have brought revolutionary advancements in biomedicine, especially in drug delivery, but their potential toxic effects necessitate thorough nanotoxicology studies before human use. Different types of nanoparticles exhibit various toxic effects, and detailed toxicity evaluations are crucial for understanding their potential harm. The increasing application of nanoparticles in drug delivery underscores the urgent need to address gaps in toxicity studies and focus on overcoming existing challenges.

CURRENT PATHOBIOLOGY REPORTS (2021)

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Review Nanoscience & Nanotechnology

Consideration for the scale-up manufacture of nanotherapeutics-A critical step for technology transfer

Xiangsheng Liu et al.

Summary: Nano-enabled biotechnology holds great promise for disease management, but achieving reproducible production of safe and effective nanotherapeutics requires careful consideration of various factors. Emerging strategies, such as the use of microfluidics systems and iterative CMC optimization, contribute to improving reproducibility and advancing nanomedicine. Personalized and just-in-time nanomedicine may be facilitated by ongoing nano-CMC research efforts.

VIEW (2021)

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Review Instruments & Instrumentation

Delivery across the blood-brain barrier: nanomedicine for glioblastoma multiforme

Lynn Jena et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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Review Pharmacology & Pharmacy

The solute carrier transporters and the brain: Physiological and pharmacological implications

Chengliang Hu et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Review Pharmacology & Pharmacy

Hyperthermia and smart drug delivery systems for solid tumor therapy

A. L. B. Seynhaeve et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Chemistry, Multidisciplinary

Ultrasound-Activated Nanomaterials for Therapeutics

Juan L. Paris et al.

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN (2020)

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Review Oncology

Ultrasound nanotheranostics in fighting cancer: Advances and prospects

Li-Qiang Zhou et al.

CANCER LETTERS (2020)

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Article Chemistry, Multidisciplinary

Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering

Margaret M. Billingsley et al.

NANO LETTERS (2020)

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Article Chemistry, Physical

The entry of nanoparticles into solid tumours

Shrey Sindhwani et al.

NATURE MATERIALS (2020)

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Article Engineering, Biomedical

Glucose-responsive insulin patch for the regulation of blood glucose in mice and minipigs

Jicheng Yu et al.

NATURE BIOMEDICAL ENGINEERING (2020)

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Article Biophysics

Study on phase transition and contrast-enhanced imaging of ultrasound-responsive nanodroplets with polymer shells

Yaqiong Li et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Pharmacology & Pharmacy

Ultrasound-Responsive Materials for Drug/Gene Delivery

Xiaowen Cai et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Chemistry, Medicinal

Smart Ultrasound-Triggered Doxorubicin-Loaded Nanoliposomes With Improved Therapeutic Response: A Comparative Study

Thanaa Shalaby et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

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Article Biotechnology & Applied Microbiology

Pulsatile Drug Delivery System Triggered by Acoustic Radiation Force

Sabrina Ciancia et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Review Materials Science, Biomaterials

Ultrasound-Responsive Carriers for Therapeutic Applications

Rajeet Chandan et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

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Review Pharmacology & Pharmacy

Stimuli-Responsive Nanomaterials for Application in Antitumor Therapy and Drug Delivery

Son H. Pham et al.

PHARMACEUTICS (2020)

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Review Chemistry, Multidisciplinary

Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies

Farshad Moradi Kashkooli et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Pharmacology & Pharmacy

Recent advances in ultrasound-triggered drug delivery through lipid-based nanomaterials

Amirhossein Ahmadi et al.

DRUG DISCOVERY TODAY (2020)

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Article Pharmacology & Pharmacy

An ultrasound responsive microbubble-liposome conjugate for targeted irinotecan-oxaliplatin treatment of pancreatic cancer

Jinhui Gao et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Article Pharmacology & Pharmacy

Deep Tumor Penetration of Doxorubicin-Loaded Glycol Chitosan Nanoparticles Using High-Intensity Focused Ultrasound

Yongwhan Choi et al.

PHARMACEUTICS (2020)

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Review Chemistry, Multidisciplinary

Ultrasound mediated therapy: Recent progress and challenges in nanoscience

Jiang Ouyang et al.

NANO TODAY (2020)

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Article Chemistry, Multidisciplinary

The dance of the nanobubbles: detecting acoustic backscatter from sub-micron bubbles using ultra-high frequency acoustic microscopy

Michael J. Moore et al.

NANOSCALE (2020)

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Article Materials Science, Multidisciplinary

Effects of magnetic nanoparticle diffusion on microwave ablation treatment: A numerical approach

M. Soltani et al.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2020)

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Review Medicine, Research & Experimental

Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications

Lei Duan et al.

THERANOSTICS (2020)

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Review Engineering, Biomedical

Ultrasound Cavitation/Microbubble Detection and Medical Applications

Zahra Izadifar et al.

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING (2019)

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Review Nanoscience & Nanotechnology

Strategies to improve tumor penetration of nanomedicines through nanoparticle design

Ya-Ru Zhang et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

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Review Multidisciplinary Sciences

Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review

Sarwar Hossen et al.

JOURNAL OF ADVANCED RESEARCH (2019)

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Review Pharmacology & Pharmacy

Stimuli-responsive nanoscale drug delivery systems for cancer therapy

Li Li et al.

JOURNAL OF DRUG TARGETING (2019)

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Review Physiology

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

John D. Martin et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 81 (2019)

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Article Biochemical Research Methods

Supramolecular Polymeric Hydrogels for Ultrasound-Guided Protein Release

Satoshi Yamaguchi et al.

BIOTECHNOLOGY JOURNAL (2019)

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Article Biophysics

Ultrasound triggered phase-change nanodroplets for doxorubicin prodrug delivery and ultrasound diagnosis: An in vitro study

Jinbiao Gao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Pharmacology & Pharmacy

Efficient exosome delivery in refractory tissues assisted by ultrasound-targeted microbubble destruction

Wenqi Sun et al.

DRUG DELIVERY (2019)

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Review Chemistry, Multidisciplinary

Clinical Trials of Thermosensitive Nanomaterials: An Overview

Stefania Nardecchia et al.

NANOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Ultrasound Reversible Response Nanocarrier Based on Sodium Alginate Modified Mesoporous Silica Nanoparticles

Xiaochong Li et al.

FRONTIERS IN CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy

Courtney van Ballegooie et al.

PHARMACEUTICS (2019)

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Article Engineering, Biomedical

Mathematical modeling in cancer nanomedicine: a review

Prashant Dogra et al.

BIOMEDICAL MICRODEVICES (2019)

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Article Peripheral Vascular Disease

Image-based spatio-temporal model of drug delivery in a heterogeneous vasculature of a solid tumor - Computational approach

Farshad Moradi Kashkooli et al.

MICROVASCULAR RESEARCH (2019)

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Article Pharmacology & Pharmacy

Sonodynamic Therapy With Anticancer Micelles and High-Intensity Focused Ultrasound in Treatment of Canine Cancer

Yuki Horise et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Chemistry, Multidisciplinary

Mathematical and computational modeling of nano-engineered drug delivery systems

Milad Shamsi et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Chemistry, Multidisciplinary

Nanobubble Liposome Complexes for Diagnostic Imaging and Ultrasound-Triggered Drug Delivery in Cancers: A Theranostic Approach

Ameya Prabhakar et al.

ACS OMEGA (2019)

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Article Nanoscience & Nanotechnology

Lipid/PLGA Hybrid Microbubbles as a Versatile Platform for Noninvasive Image-Guided Targeted Drug Delivery

Yan Chen et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Results of first-in-man proof of concept study of ultrasound-triggered drug delivery in liver tumours

Paul C. Lyon et al.

CLINICAL RADIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Brain Delivery of Curcumin Using Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Preparation, Optimization, and Pharmacokinetic Evaluation

Soroor Sadegh Malvajerd et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Review Pharmacology & Pharmacy

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers

Zongmin Zhao et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Review Biotechnology & Applied Microbiology

Nano-Enhanced Drug Delivery and Therapeutic Ultrasound for Cancer Treatment and Beyond

Priyanka Tharkar et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Review Cell Biology

Actin-microtubule crosstalk in cell biology

Marileen Dogterom et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I Trial

Michael D. Gray et al.

RADIOLOGY (2019)

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Article Acoustics

Effects of ultrasound pulse parameters on cavitation properties of flowing microbubbles under physiologically relevant conditions

Mouwen Cheng et al.

ULTRASONICS SONOCHEMISTRY (2019)

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Review Chemistry, Multidisciplinary

Ultrasound responsive mesoporous silica nanoparticles for biomedical applications

Miguel Manzano et al.

CHEMICAL COMMUNICATIONS (2019)

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Review Biotechnology & Applied Microbiology

Nanoparticles in the clinic: An update

Aaron C. Anselmo et al.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2019)

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Article Medicine, Research & Experimental

Nanotopography-based lymphatic delivery for improved anti-tumor responses to checkpoint blockade immunotherapy

Sunkuk Kwon et al.

THERANOSTICS (2019)

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Article Oncology

Hyperthermia-enhanced targeted drug delivery using magnetic resonance-guided focussed ultrasound: a pre-clinical study in a genetic model of pancreatic cancer

Navid Farr et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2018)

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Review Toxicology

Potential applications and human biosafety of nanomaterials used in nanomedicine

Hong Su et al.

JOURNAL OF APPLIED TOXICOLOGY (2018)

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Article Chemistry, Physical

Ultrasound-triggered release of sinoporphyrin sodium from liposome-microbubble complexes and its enhanced sonodynamic toxicity in breast cancer

Yixiang Li et al.

NANO RESEARCH (2018)

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Review Instruments & Instrumentation

Ultrasound-based triggered drug delivery to tumors

Ankit Jain et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2018)

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Article Chemistry, Multidisciplinary

Quantifying the Ligand-Coated Nanoparticle Delivery to Cancer Cells in Solid Tumors

Qin Dai et al.

ACS NANO (2018)

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Article Engineering, Environmental

Nanoparticle-assisted ultrasound: A special focus on sonodynamic therapy against cancer

Giancarlo Canavese et al.

CHEMICAL ENGINEERING JOURNAL (2018)

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Review Pharmacology & Pharmacy

Role of Solid-Gas Interface of Nanobubbles for Therapeutic Applications

Pravin K. Shende et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2018)

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Review Biochemistry & Molecular Biology

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

Miliotou N. Androulla et al.

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2018)

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Article Oncology

Sensitization of Hypoxic Tumors to Radiation Therapy Using Ultrasound-Sensitive Oxygen Microbubbles

John R. Eisenbrey et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2018)

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Article Physics, Applied

Selective detection of cavitation bubbles by triplet pulse sequence in high-intensity focused ultrasound treatment

Ryosuke Iwasaki et al.

JAPANESE JOURNAL OF APPLIED PHYSICS (2018)

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Review Chemistry, Multidisciplinary

Mechanistic understanding the bioeffects of ultrasound-driven microbubbles to enhance macromolecule delivery

Peng Qin et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Review Chemistry, Multidisciplinary

Ignoring the modeling approaches: Towards the shadowy paths in nanomedicine

Parichehr Hassanzadeh et al.

JOURNAL OF CONTROLLED RELEASE (2018)

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Article Oncology

Safety and feasibility of ultrasound-triggered targeted drug delivery of doxorubicin from thermosensitive liposomes in liver tumours (TARDOX): a single-centre, open-label, phase 1 trial

Paul C. Lyon et al.

LANCET ONCOLOGY (2018)

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Review Surgery

Principles of focused ultrasound

Senay Mihcin et al.

MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES (2018)

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Review Multidisciplinary Sciences

Manipulating nanoparticle transport within blood flow through external forces: an exemplar of mechanics in nanomedicine

Huilin Ye et al.

PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2018)

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Article Acoustics

MONODISPERSE VERSUS POLYDISPERSE ULTRASOUND CONTRAST AGENTS: NON-LINEAR RESPONSE, SENSITIVITY, AND DEEP TISSUE IMAGING POTENTIAL

Tim Segers et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2018)

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Article Materials Science, Multidisciplinary

Perfluorocarbon-based nanomedicine: emerging strategy for diagnosis and treatment of diseases

Tingbin Zhang et al.

MRS COMMUNICATIONS (2018)

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Article Chemistry, Multidisciplinary

Focused Ultrasound-Augmented Delivery of Biodegradable Multifunctional Nanoplatforms for Imaging-Guided Brain Tumor Treatment

Meiying Wu et al.

ADVANCED SCIENCE (2018)

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Review Radiology, Nuclear Medicine & Medical Imaging

High intensity focused ultrasound: The fundamentals, clinical applications and research trends

I. A. Shehata Elhelf et al.

DIAGNOSTIC AND INTERVENTIONAL IMAGING (2018)

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Article Oncology

Active Role of the Necrotic Zone in Desensitization of Hypoxic Macrophages and Regulation of CSC-Fate: A hypothesis

Maryam Mehrabi et al.

FRONTIERS IN ONCOLOGY (2018)

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Article Chemistry, Physical

Diffusion limited green synthesis of ultra-small gold nanoparticles at room temperature

Maurizio Celentano et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2018)

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Review Chemistry, Medicinal

Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release

Salma E. Ahmed et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2018)

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Article Radiology, Nuclear Medicine & Medical Imaging

Gold nanoparticle-induced sonosensitization enhances the antitumor activity of ultrasound in colon tumor-bearing mice

Jaber Beik et al.

MEDICAL PHYSICS (2018)

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Article Medicine, General & Internal

Estimated Costs of Pivotal Trials for Novel Therapeutic Agents Approved by the US Food and Drug Administration, 2015-2016

Thomas J. Moore et al.

JAMA INTERNAL MEDICINE (2018)

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Review Oncology

Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

Nemany A. N. Hanafy et al.

CANCERS (2018)

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Review Pharmacology & Pharmacy

Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation

Sofie Snipstad et al.

EXPERT OPINION ON DRUG DELIVERY (2018)

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Article Polymer Science

Encapsulation and Ultrasound-Triggered Release of G-Quadruplex DNA in Multilayer Hydrogel Microcapsules

Aaron Alford et al.

POLYMERS (2018)

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Article Oncology

Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system

Yanjie Wang et al.

CHINESE JOURNAL OF CANCER RESEARCH (2018)

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Review Oncology

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside

Triantafyllos Stylianopoulos et al.

TRENDS IN CANCER (2018)

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Editorial Material Dentistry, Oral Surgery & Medicine

Ultrasound-mediated drug delivery

S. T. Sonis

ORAL DISEASES (2017)

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Review Nanoscience & Nanotechnology

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Jing Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Pharmacology & Pharmacy

Exosomes as novel bio-carriers for gene and drug delivery

Xin-Chi Jiang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Multidisciplinary

Ultrasound-induced mild hyperthermia improves the anticancer efficacy of both Taxol® and paclitaxel-loaded nanocapsules

Tanguy Boissenot et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Chemistry, Multidisciplinary

MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound

Kelsie F. Timbie et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Article Chemistry, Multidisciplinary

Polypyrrole-Coated Perfluorocarbon Nanoemulsions as a Sono-Photoacoustic Contrast Agent

David S. Li et al.

NANO LETTERS (2017)

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Article Multidisciplinary Sciences

Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model

Tao Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Thermal combination therapies for local drug delivery by magnetic resonance-guided high-intensity focused ultrasound

Nicole Hijnen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Medicine, Research & Experimental

Efficient Enhancement of Blood-Brain Barrier Permeability Using Acoustic Cluster Therapy (ACT)

Andreas K. O. Aslund et al.

THERANOSTICS (2017)

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Article Chemistry, Inorganic & Nuclear

Self-assembly of gold nanowire networks into gold foams: production, ultrastructure and applications

A. Jakhmola et al.

INORGANIC CHEMISTRY FRONTIERS (2017)

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Review Oncology

Transport of drugs from blood vessels to tumour tissue

Mark W. Dewhirst et al.

NATURE REVIEWS CANCER (2017)

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Review Medicine, Research & Experimental

A review on the efficacy and toxicity of different doxorubicin nanoparticles for targeted therapy in metastatic breast cancer

Ayman Shafei et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Review Radiology, Nuclear Medicine & Medical Imaging

Ultrasound-guided drug delivery in cancer

Sayan Mullick Chowdhury et al.

ULTRASONOGRAPHY (2017)

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Article Acoustics

Photoacoustic signal characterization of cancer treatment response: Correlation with changes in tumor oxygenation

Eno Hysi et al.

PHOTOACOUSTICS (2017)

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Review Chemistry, Multidisciplinary

Mechanical Force-Triggered Drug Delivery

Yuqi Zhang et al.

CHEMICAL REVIEWS (2016)

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Review Chemistry, Multidisciplinary

Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release

Nazila Kamaly et al.

CHEMICAL REVIEWS (2016)

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Review Chemistry, Multidisciplinary

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Mahdi Karimi et al.

CHEMICAL SOCIETY REVIEWS (2016)

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Article Biochemistry & Molecular Biology

Novel alginate-stabilized doxorubicin-loaded nanodroplets for ultrasounic theranosis of breast cancer

Fatemeh Baghbani et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

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Article Chemistry, Multidisciplinary

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

Georg Dimcevski et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

The release of Doxorubicin from liposomes monitored by MRI and triggered by a combination of US stimuli led to a complete tumor regression in a breast cancer mouse model

S. Rizzitelli et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Review Chemistry, Multidisciplinary

Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications

Tanguy Boissenot et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

Synthesis of Stable Multifunctional Perfluorocarbon Nanoemulsions for Cancer Therapy and Imaging

Donald A. Fernandes et al.

LANGMUIR (2016)

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Review Biochemistry & Molecular Biology

Recent Advances in Stimuli-Responsive Release Function Drug Delivery Systems for Tumor Treatment

Chendi Ding et al.

MOLECULES (2016)

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Article Chemistry, Multidisciplinary

Ultrasound-responsive ultrathin multiblock copolyamide vesicles

Lei Huang et al.

NANOSCALE (2016)

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Article Multidisciplinary Sciences

Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes

Jonathan P. May et al.

PLoS One (2016)

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Article Cell Biology

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Alexandre Carpentier et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Article Acoustics

Ultrasound responsive block copolymer micelle of poly(ethylene glycol)-poly(propylene glycol) obtained through click reaction

Fayong Li et al.

ULTRASONICS SONOCHEMISTRY (2016)

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Article Acoustics

ULTRASOUND EFFECT ON CANCEROUS VERSUS NON-CANCEROUS CELLS

Aharon Azagury et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2016)

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Article Biotechnology & Applied Microbiology

Application of liposomes in medicine and drug delivery

Hadis Daraee et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2016)

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Article Chemistry, Multidisciplinary

Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers

Juan L. Paris et al.

ACS NANO (2015)

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Article Radiology, Nuclear Medicine & Medical Imaging

Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery

Yrr Morch et al.

CONTRAST MEDIA & MOLECULAR IMAGING (2015)

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Article Oncology

Towards a dosimetric framework for therapeutic ultrasound

Adam Shaw et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2015)

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Article Chemistry, Multidisciplinary

Polymeric micelles and nanoemulsions as drug carriers: Therapeutic efficacy, toxicity, and drug resistance

Roohi Gupta et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Multidisciplinary

Formulation and optimization of idarubicin thermosensitive liposomes provides ultrafast triggered release at mild hyperthermia and improves tumor response

Tao Lu et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Nanoscience & Nanotechnology

Design considerations for nanotherapeutics in oncology

Triantafyllos Stylianopoulos et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Article Biotechnology & Applied Microbiology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

Elvin Blanco et al.

NATURE BIOTECHNOLOGY (2015)

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Article Engineering, Mechanical

Influence of the pressure-dependent resonance frequency on the bifurcation structure and backscattered pressure of ultrasound contrast agents: a numerical investigation

Amin Jafari Sojahrood et al.

NONLINEAR DYNAMICS (2015)

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Article Chemistry, Multidisciplinary

Ultrasound-Propelled Nanocups for Drug Delivery

James J. Kwan et al.

SMALL (2015)

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Review Neurosciences

The Molecular Constituents of the Blood-Brain Barrier

Brian Wai Chow et al.

TRENDS IN NEUROSCIENCES (2015)

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Review Acoustics

MECHANICAL HIGH-INTENSITY FOCUSED ULTRASOUND DESTRUCTION OF SOFT TISSUE: WORKING MECHANISMS AND PHYSIOLOGIC EFFECTS

Martijn Hoogenboom et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2015)

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Article Engineering, Biomedical

Bioinspired Oil Core/Silica Shell Nanocarriers with Tunable and Multimodal Functionalities

Anshuman Jakhmola et al.

ADVANCED HEALTHCARE MATERIALS (2015)

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Review Pharmacology & Pharmacy

The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes

Salma E. Ahmed et al.

JOURNAL OF DRUG TARGETING (2015)

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Proceedings Paper Physics, Applied

MRI Compatible Ultrasound Transducers for Simultaneous Acquisition of Coregistered Ultrasound to MRI Data

Daniel Speicher et al.

Proceedings of the 2015 ICU International Congress on Ultrasonics (2015)

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Article Engineering, Biomedical

Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors

Triantafyllos Stylianopoulos et al.

ANNALS OF BIOMEDICAL ENGINEERING (2015)

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Review Radiology, Nuclear Medicine & Medical Imaging

Contrast-enhanced ultrasonography: advance and current status in abdominal imaging

Yong Eun Chung et al.

ULTRASONOGRAPHY (2015)

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Review Chemistry, Multidisciplinary

Construction of Homogenous/Heterogeneous Hollow Mesoporous Silica Nanostructures by Silica-Etching Chemistry: Principles, Synthesis, and Applications

Yu Chen et al.

ACCOUNTS OF CHEMICAL RESEARCH (2014)

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Review Pharmacology & Pharmacy

Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms

I. Lentacker et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

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Review Pharmacology & Pharmacy

State-of-the-art materials for ultrasound-triggered drug delivery

Shashank R. Sirsi et al.

ADVANCED DRUG DELIVERY REVIEWS (2014)

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Article Biochemistry & Molecular Biology

Influence of Reducing Agents on Biosafety and Biocompatibility of Gold Nanoparticles

Dong-Lin Xia et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2014)

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Review Biophysics

Ultrasonically triggered drug delivery: Breaking the barrier

Ghaleb A. Husseini et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2014)

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Article Oncology

Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer

Timothy M. Zagar et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2014)

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Article Chemistry, Multidisciplinary

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

Heleen Dewitte et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Chemistry, Multidisciplinary

Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes

Susan M. Graham et al.

JOURNAL OF CONTROLLED RELEASE (2014)

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Article Chemistry, Multidisciplinary

High Intensity Focused Ultrasound Responsive Metallo-supramolecular Block Copolymer Micelles

Bo Liang et al.

LANGMUIR (2014)

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Review Chemistry, Multidisciplinary

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

Sutapa Barua et al.

NANO TODAY (2014)

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Article Biotechnology & Applied Microbiology

Clinical development success rates for investigational drugs

Michael Hay et al.

NATURE BIOTECHNOLOGY (2014)

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Article Acoustics

HIGH-INTENSITY FOCUSED ULTRASOUND TREATMENT OF LATE-STAGE PANCREATIC BODY CARCINOMA: OPTIMAL TUMOR DEPTH FOR SAFE ABLATION

Hui-Yu Ge et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2014)

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Article Medicine, Research & Experimental

Ultrasound-Mediated Gene and Drug Delivery Using a Microbubble-Liposome Particle System

Young Il Yoon et al.

THERANOSTICS (2014)

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Review Biotechnology & Applied Microbiology

Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

Qiu-Lan Zhou et al.

BIOMED RESEARCH INTERNATIONAL (2014)

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Review Medicine, Research & Experimental

Barriers to drug delivery in solid tumors

Shravan Kumar Sriraman et al.

TISSUE BARRIERS (2014)

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Article Rheumatology

Nanoparticles and the Mononuclear Phagocyte System: Pharmacokinetics and Applications for Inflammatory Diseases

Gina Song et al.

CURRENT RHEUMATOLOGY REVIEWS (2014)

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Review Oncology

Thermal ablation of tumours: biological mechanisms and advances in therapy

Katrina F. Chu et al.

NATURE REVIEWS CANCER (2014)

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Review Chemistry, Multidisciplinary

Physicochemical Properties Determine Nanomaterial Cellular Uptake, Transport, and Fate

Motao Zhu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Article Urology & Nephrology

Perfluorocarbon Nanoparticles for Physiological and Molecular Imaging and Therapy

Junjie Chen et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2013)

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Article Engineering, Biomedical

The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes

Changhui Fu et al.

BIOMATERIALS (2013)

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Article Pharmacology & Pharmacy

In vivo monitoring of liposomal release in tumours following ultrasound stimulation

Tove J. Evjen et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2013)

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Review Pharmacology & Pharmacy

Hyperthermia-induced drug targeting

Jonathan P. May et al.

EXPERT OPINION ON DRUG DELIVERY (2013)

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Article Cell Biology

Stimulus-responsive nanopreparations for tumor targeting

Lin Zhu et al.

INTEGRATIVE BIOLOGY (2013)

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Review Pharmacology & Pharmacy

Polymeric micelles and alternative nanonized delivery vehicles for poorly soluble drugs

Ying Lu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2013)

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Article Chemistry, Multidisciplinary

Complete regression of local cancer using temperature-sensitive liposomes combined with ultrasound-mediated hyperthermia

Azadeh Kheirolomoom et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Chemistry, Multidisciplinary

Evidence for a new mechanism behind HIFU-triggered release from liposomes

Chris Oerlemans et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Chemistry, Multidisciplinary

Targeted drug delivery with focused ultrasound-induced blood-brain barrier opening using acoustically-activated nanodroplets

Cherry C. Chen et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Article Chemistry, Multidisciplinary

Improved intratumoral nanoparticle extravasation and penetration by mild hyperthermia

Li Li et al.

JOURNAL OF CONTROLLED RELEASE (2013)

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Review Biotechnology & Applied Microbiology

Therapeutic nanoparticles in clinics and under clinical evaluation

Catherine A. Schuetz et al.

NANOMEDICINE (2013)

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Article Radiology, Nuclear Medicine & Medical Imaging

Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: A clinical case study

Spiros Kotopoulis et al.

MEDICAL PHYSICS (2013)

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Article Acoustics

ACOUSTIC CHARACTERIZATION AND PHARMACOKINETIC ANALYSES OF NEW NANOBUBBLE ULTRASOUND CONTRAST AGENTS

Hanping Wu et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2013)

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Article Materials Science, Biomaterials

Fast release behavior of block copolymer micelles under high intensity focused ultrasound/redox combined stimulus

Rui Tong et al.

JOURNAL OF MATERIALS CHEMISTRY B (2013)

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Review Physiology

pH sensing and regulation in cancer

Mehdi Damaghi et al.

FRONTIERS IN PHYSIOLOGY (2013)

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Article Oncology

Ultrasound Increases Nanoparticle Delivery by Reducing Intratumoral Pressure and Increasing Transport in Epithelial and Epithelial-Mesenchymal Transition Tumors

Katherine D. Watson et al.

CANCER RESEARCH (2012)

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Review Oncology

Clinical and future applications of high intensity focused ultrasound in cancer

Osama Al-Bataineh et al.

CANCER TREATMENT REVIEWS (2012)

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Article Acoustics

Intravascular Ultrasound Catheter to Enhance Microbubble-Based Drug Delivery via Acoustic Radiation Force

Joseph P. Kilroy et al.

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2012)

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Review Chemistry, Multidisciplinary

Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound

Holger Grull et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Chemistry, Multidisciplinary

Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model

Ashish Ranjan et al.

JOURNAL OF CONTROLLED RELEASE (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Phase I Study of Heat-Deployed Liposomal Doxorubicin during Radiofrequency Ablation for Hepatic Malignancies

Bradford J. Wood et al.

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY (2012)

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Article Chemistry, Multidisciplinary

Ultrasound-Responsive Block Copolymer Micelles Based on a New Amplification Mechanism

Juan Xuan et al.

LANGMUIR (2012)

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Article Radiology, Nuclear Medicine & Medical Imaging

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions-based Controller

Meaghan A. O'Reilly et al.

RADIOLOGY (2012)

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Article Cell Biology

Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus

Laura M. Ensign et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

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Review Nanoscience & Nanotechnology

Phase-shift, stimuli-responsive perfluorocarbon nanodroplets for drug delivery to cancer

Natalya Rapoport

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2012)

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Article Medicine, Research & Experimental

Theranostic Oxygen Delivery Using Ultrasound and Microbubbles

James J. Kwan et al.

THERANOSTICS (2012)

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Article Medicine, Research & Experimental

Vascular Normalization as a Therapeutic Strategy for Malignant and Nonmalignant Disease

Shom Goel et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

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Proceedings Paper Physics, Applied

Overcoming Biological Barriers with Ultrasound

Dhaval Thakkar et al.

11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (2012)

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Proceedings Paper Physics, Applied

The Utilization of the Bubble Pressure Dependent Harmonic Resonance Frequency for Enhanced Heating during High Intensity Focused Ultrasound Treatments

Amin Jafari Sojahrood et al.

11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (2012)

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Proceedings Paper Physics, Applied

Optimization of the Shear Stress Induced by Ultrasonically-Stimulated Oscillating MBs: A Theoretical Investigation

Amin Jafari Sojahrood et al.

11TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (2012)

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Article Chemistry, Multidisciplinary

Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model

Huan Meng et al.

ACS NANO (2011)

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Review Anesthesiology

Potential Adverse Ultrasound-related Biological Effects A Critical Review

Hariharan Shankar et al.

ANESTHESIOLOGY (2011)

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Article Chemistry, Multidisciplinary

Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study

Mariska de Smet et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Chemistry, Multidisciplinary

Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery

Bart Geers et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Review Chemistry, Multidisciplinary

Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles

Ryo Suzuki et al.

JOURNAL OF CONTROLLED RELEASE (2011)

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Article Pharmacology & Pharmacy

Ultrasound enhanced antitumor activity of liposomal doxorubicin in mice

Eirik Hagtvet et al.

JOURNAL OF DRUG TARGETING (2011)

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Article Chemistry, Multidisciplinary

Tailor-Made Dual pH-Sensitive Polymer-Doxorubicin Nanoparticles for Efficient Anticancer Drug Delivery

Jin-Zhi Du et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of the Temporal Window for Drug Delivery Following Ultrasound-Mediated Membrane Permeability Enhancement

Anna Yudina et al.

MOLECULAR IMAGING AND BIOLOGY (2011)

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Article Physics, Multidisciplinary

Blood Vessel Deformations on Microsecond Time Scales by Ultrasonic Cavitation

Hong Chen et al.

PHYSICAL REVIEW LETTERS (2011)

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Review Radiology, Nuclear Medicine & Medical Imaging

Focused Ultrasound Surgery in Oncology: Overview and Principles

Clare M. C. Tempany et al.

RADIOLOGY (2011)

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Article Acoustics

Effect of local dual frequency sonication on drug distribution from polymeric nanomicelles

Hadi Hasanzadeh et al.

ULTRASONICS SONOCHEMISTRY (2011)

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Review Chemistry, Applied

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

Vikash P. Chauhan et al.

ANNUAL REVIEW OF CHEMICAL AND BIOMOLECULAR ENGINEERING, VOL 2 (2011)

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Article Engineering, Biomedical

Heat-sensitive microbubbles for intraoperative assessment of cancer ablation margins

Jiwei Huang et al.

BIOMATERIALS (2010)

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Article Chemistry, Multidisciplinary

Focused ultrasound and microbubbles for enhanced extravasation

M. R. Bohmer et al.

JOURNAL OF CONTROLLED RELEASE (2010)

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Article Chemistry, Multidisciplinary

Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: A tool for targeted drug delivery

Alexander L. Klibanov et al.

JOURNAL OF CONTROLLED RELEASE (2010)

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Article Biochemistry & Molecular Biology

Ultrasonically Induced Release from Nanosized Polymer Vesicles

Gautam D. Pangu et al.

MACROMOLECULAR BIOSCIENCE (2010)

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Review Oncology

Delivering nanomedicine to solid tumors

Rakesh K. Jain et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2010)

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Article Acoustics

An in vitro feasibility study of controlled drug release from encapsulated nanometer liposomes using high intensity focused ultrasound

Di Chen et al.

ULTRASONICS (2010)

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Review Biochemistry & Molecular Biology

Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes

Avi Schroeder et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2009)

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Article Pharmacology & Pharmacy

Ultrasound-mediated oxygen delivery from chitosan nanobubbles

Roberta Cavalli et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)

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Article Chemistry, Multidisciplinary

Ultrasound triggered release of cisplatin from liposomes in murine tumors

Avi Schroeder et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Article Chemistry, Multidisciplinary

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

Natalya Y. Rapoport et al.

JOURNAL OF CONTROLLED RELEASE (2009)

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Article Chemistry, Multidisciplinary

High-Frequency Ultrasound-Responsive Block Copolymer Micelle

Jie Wang et al.

LANGMUIR (2009)

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Article Nanoscience & Nanotechnology

Assessment of the In Vivo Toxicity of Gold Nanoparticles

Yu-Shiun Chen et al.

NANOSCALE RESEARCH LETTERS (2009)

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Article Acoustics

SONOPORATION BY ULTRASOUND-ACTIVATED MICROBUBBLE CONTRAST AGENTS: EFFECT OF ACOUSTIC EXPOSURE PARAMETERS ON CELL MEMBRANE PERMEABILITY AND CELL VIABILITY

Raffi Karshafian et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2009)

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Review Pharmacology & Pharmacy

Ultrasound mediated delivery of drugs and genes to solid tumors

Victor Frenkel

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Review Pharmacology & Pharmacy

Ultrasound for drug and gene delivery to the brain

Kullervo Hynynen

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Review Pharmacology & Pharmacy

Micelles and nanoparticles for ultrasonic drug and gene delivery

Ghaleb A. Husseini et al.

ADVANCED DRUG DELIVERY REVIEWS (2008)

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Review Pharmacology & Pharmacy

Ultrasound targeted microbubble destruction for drug and gene delivery

Christian R. Mayer et al.

EXPERT OPINION ON DRUG DELIVERY (2008)

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Review Nanoscience & Nanotechnology

Drug delivery and nanoparticles: Applications and hazards

Wim H. De Jong et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2008)

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Editorial Material Pharmacology & Pharmacy

Gregory Gregoriadis: Introducing liposomes to drug delivery

Yvonne Perrie

JOURNAL OF DRUG TARGETING (2008)

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Article Acoustics

Drug-loaded nano/microbubbles for combining ultrasonography and targeted chemotherapy

Zhonggao Gao et al.

ULTRASONICS (2008)

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Article Acoustics

OSTEOGENIC EFFECTS OF LOW-INTENSITY PULSED ULTRASOUND, EXTRACORPOREAL SHOCKWAVES AND THEIR COMBINATION - AN IN VITRO COMPARATIVE STUDY ON HUMAN PERIOSTEAL CELLS

Kam-Fai Tam et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2008)

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Review Nanoscience & Nanotechnology

Nanocarriers as an emerging platform for cancer therapy

Dan Peer et al.

NATURE NANOTECHNOLOGY (2007)

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Article Oncology

Tumor necrosis factor α mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response

Ann L. B. Seynhaeve et al.

CANCER RESEARCH (2007)

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Review Pharmacology & Pharmacy

Endocytic mechanisms for targeted drug delivery

Lisa A. Bareford et al.

ADVANCED DRUG DELIVERY REVIEWS (2007)

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Review Polymer Science

Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery

Natalya Rapoport

PROGRESS IN POLYMER SCIENCE (2007)

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Article Medicine, Research & Experimental

Ethical issues in clinical trials involving nanomedicine

David B. Resnik et al.

CONTEMPORARY CLINICAL TRIALS (2007)

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Article Oncology

Pulsed-high intensity focused ultrasound and low temperature sensitive liposomes for enhanced targeted drug delivery and antitumor effect

Sergio Dromi et al.

CLINICAL CANCER RESEARCH (2007)

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Article Chemistry, Multidisciplinary

Controlling liposomal drug release with low frequency ultrasound: Mechanism and feasibility

Avi Schroeder et al.

LANGMUIR (2007)

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Article Chemistry, Multidisciplinary

Release of doxorubicin from unstabilized and stabilized micelles under the action of ultrasound

Ghaleb A. Husseini et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2007)

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Article Chemistry, Multidisciplinary

Gene delivery by combination of novel liposomal bubbles with perfluoropropane and ultrasound

Ryo Suzuki et al.

JOURNAL OF CONTROLLED RELEASE (2007)

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Article Oncology

Hyperthermia mediated liposomal drug delivery

Ana M. Ponce et al.

INTERNATIONAL JOURNAL OF HYPERTHERMIA (2006)

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Article Oncology

Synergistic and tumour selective effects of chemotherapy and ultrasound treatment

G Myhr et al.

CANCER LETTERS (2006)

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Article Oncology

The comet assay to determine the mode of cell death for the ultrasonic delivery of doxorubicin to human leukemia (HL-60 cells) from pluronic P105 micelles

GA Husseini et al.

TECHNOLOGY IN CANCER RESEARCH & TREATMENT (2005)

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Article Oncology

High-intensity focused ultrasound in the treatment of solid tumours

JE Kennedy

NATURE REVIEWS CANCER (2005)

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Article Biotechnology & Applied Microbiology

Innovation - Healing sound: the use of ultrasound in drug delivery and other therapeutic applications

S Mitragotri

NATURE REVIEWS DRUG DISCOVERY (2005)

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Article Biotechnology & Applied Microbiology

Understanding the fundamentals of perfluorocarbons and perfluorocarbon emulsions relevant to in vivo oxygen delivery

JG Riess

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY (2005)

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Article Chemistry, Multidisciplinary

Controlled and targeted tumor chemotherapy by micellar-encapsulated drug and ultrasound

ZG Gao et al.

JOURNAL OF CONTROLLED RELEASE (2005)

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Review Pharmacology & Pharmacy

Low-frequency sonophoresis - A review

S Mitragotri et al.

ADVANCED DRUG DELIVERY REVIEWS (2004)

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Review Oncology

High interstitial fluid pressure -: An obstacle in cancer therapy

CH Heldin et al.

NATURE REVIEWS CANCER (2004)

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Article Acoustics

Perspectives in clinical uses of high-intensity focused ultrasound

GT Clement

ULTRASONICS (2004)

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Article Pharmacology & Pharmacy

Combined cancer therapy by micellar-encapsulated drug and ultrasound

N Rapoport

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2004)

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Article Oncology

Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles

GA Husseini et al.

BMC CANCER (2002)

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Review Pharmacology & Pharmacy

Drug transport to the brain:: Key roles for the efflux pump P-glycoprotein in the blood-brain barrier

M Demeule et al.

VASCULAR PHARMACOLOGY (2002)

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Article Chemistry, Multidisciplinary

Acoustic activation of drug delivery from polymeric micelles: effect of pulsed ultrasound

A Marin et al.

JOURNAL OF CONTROLLED RELEASE (2001)

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Article Chemistry, Multidisciplinary

Factors affecting acoustically triggered release of drugs from polymeric micelles

GA Husseini et al.

JOURNAL OF CONTROLLED RELEASE (2000)

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Article Physics, Multidisciplinary

Effect of noble gases on sonoluminescence temperatures during multibubble cavitation

YT Didenko et al.

PHYSICAL REVIEW LETTERS (2000)

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Article Chemistry, Multidisciplinary

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

H Maeda et al.

JOURNAL OF CONTROLLED RELEASE (2000)

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