☆ 4.8 Article

Metal coordination micelles for anti-cancer treatment by gene-editing and phototherapy

JOURNAL OF CONTROLLED RELEASE (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Engineering, Biomedical

Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment

Zhijuan Yang et al.

Summary: This study developed bioluminescent bacteria as an internal light source to enhance photodynamic therapy (PDT). The bioluminescence-triggered PDT showed significant advantages over conventional PDT and could also induce potent antitumor immunity. This research provides a general and highly effective therapeutic approach for diverse cancers with varying light-absorbing capacities and tumor sizes.

BIOMATERIALS (2022)

添加到收藏夹

Article Biophysics

Tumor microenvironment based stimuli-responsive CRISPR/Cas delivery systems: A viable platform for interventional approaches

Nanyang Tang et al.

Summary: Intelligent delivery systems incorporating sensitive materials in response to endogenous stimuli of the tumor microenvironment have shown potential for tumor-specific genome editing and reduced side effects of CRISPR/Cas in cancer gene therapy.

COLLOIDS AND SURFACES B-BIOINTERFACES (2022)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chemodynamic Therapy via Fenton and Fenton-Like Nanomaterials: Strategies and Recent Advances

Chenyang Jia et al.

Summary: Chemodynamic therapy (CDT) is a novel cancer treatment strategy that generates hydroxyl radicals in the tumor region using Fenton or Fenton-like reactions. It has advantages such as low side effects, independence from external stimulation, modulation of the tumor microenvironment, and low treatment cost. CDT can also be combined with other therapies to enhance anticancer effects.

SMALL (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Surfactant-Stripped Semiconducting Polymer Micelles for Tumor Theranostics and Deep Tissue Imaging in the NIR-II Window

Yuanmeng Ding et al.

Summary: The study introduces a semiconducting polymer with strong absorption in the second near infrared (NIR-II) window, leading to the development of surfactant-stripped semiconductor polymeric micelles (SSS-micelles) with water solubility and high photothermal conversion efficiency for deep tissue imaging and tumor theranostics.

SMALL (2022)

添加到收藏夹

Article Engineering, Biomedical

Effective Genome Editing Using CRISPR-Cas9 Nanoflowers

Chen Zhang et al.

Summary: This study reports a new gene editing delivery nanoplatform, Cas9-NF, which enables efficient intracellular delivery and controlled release of Cas9 in tumor cells. The flower-like morphology of this nanoplatform can be flexibly tuned by protein concentration and crosslinker types, while protecting the stability of Cas9 protein under extreme pH conditions. The responsive cleavage of crosslinkers in tumor cells allows for efficient gene knockout and inhibition of tumor growth.

ADVANCED HEALTHCARE MATERIALS (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Multifunctional DNAzyme-Anchored Metal-Organic Framework for Efficient Suppression of Tumor Metastasis

Yun Zhao et al.

Summary: This study developed a versatile theranostic agent to combat metastatic tumors. By delivering a specific DNAzyme, it effectively inhibits the invasion of cancer cells through gene silencing. The combined gene/chemodynamic therapy is achieved by self-supplied DNAzyme cofactors and efficient glutathione depletion. Additionally, the photothermal stimuli further promote the therapeutic strategy and accelerate the release of DNAzyme, resulting in effective tumor elimination and metastasis blockage.

ACS NANO (2022)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Metal-based nano-vaccines for cancer immunotherapy

Jiexin Li et al.

Summary: Metalloimmunology has the potential to revitalize cancer vaccines by utilizing metal-based nanomaterials as adjuvants or delivery carriers to enhance immunity and improve the induction of antigen specific T cells for cancer immunotherapy.

COORDINATION CHEMISTRY REVIEWS (2022)

添加到收藏夹

Article Engineering, Biomedical

Anti‐PD‐L1 DNAzyme Loaded Photothermal Mn 2+ /Fe 3+ Hybrid Metal‐Phenolic Networks for Cyclically Amplified Tumor Ferroptosis‐Immunotherapy (Adv. Healthcare Mater. 8/2022)

Peng Liu et al.

Advanced Healthcare Materials (2022)

添加到收藏夹

Article Chemistry, Multidisciplinary

Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade

Zhiren Wang et al.

Summary: Camptothesome is an innovative nanovesicle therapeutic that has shown promising results in the treatment of colorectal cancer. It is taken up by cancer cells through a specific pathway and induces immunogenic cancer cell death. The use of Camptothesome-treated tumor cells as a vaccine has proven effective in preventing tumor growth. Furthermore, Camptothesome demonstrates superior anti-cancer efficacy and immune response compared to other treatments. It also enhances the effectiveness of immune checkpoint inhibitors in shrinking late-stage CRC tumors and prolonging survival.

JOURNAL OF CONTROLLED RELEASE (2022)

添加到收藏夹

Article Chemistry, Analytical

Smart Catalyzed Hairpin Assembly-Induced DNAzyme Nanosystem for Intracellular UDG Imaging

Xiaolei Song et al.

Summary: A smart catalyzed hairpin assembly (CHA) DNAzyme nanosystem has been developed for intracellular UDG imaging, utilizing MnO2 nanosheets as nanocarriers to efficiently deliver DNA probes into cells and promote the fluorescence resonance energy transfer response. This approach offers enhanced sensitivity for early-stage cancer prediction and diagnosis.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

Ziling Zeng et al.

Summary: This study introduces an organic polymer nanoenzyme (SPNK) with near-infrared (NIR) photoactivatable immunotherapeutic effects for photodynamic immunometabolic therapy. By generating singlet oxygen (O-1(2)) upon NIR photoirradiation, SPNK induces immunogenic cell death of cancer and degrades immunosuppressive kynurenine (Kyn), ultimately promoting effector T cell proliferation and infiltration, enhancing systemic antitumor T cell immunity, and inhibiting both primary and distant tumors in living mice.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Light-Triggered Transformable Ferrous Ion Delivery System for Photothermal Primed Chemodynamic Therapy

Ting He et al.

Summary: This study introduces a near-infrared light-triggered Fe2+ delivery agent (LET6) that can catalyze H2O2 in the tumor microenvironment, achieving high therapeutic efficacy for cancer treatment. The use of LET6 provides a potential strategy for synergistic metal-ion-mediated cancer therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Article Chemistry, Physical

Magnetic Metal Micelles for Enhanced Delivery of Self-Immolating CD8+ T-Cell Epitopes for Cancer Immunotherapy

Jiexin Li et al.

Summary: A self-assembled magnetic micelle delivery system was developed for targeted delivery of CD8(+) T-cell epitopes, producing strong cellular immune responses. Metal ions enhanced vaccine immunogenicity, while a self-immolative linker allowed for rapid antigen release. The system eradicated tumors in a mouse model, demonstrating potential for developing a new generation of cancer vaccines with multiple functionalities.

CHEMISTRY OF MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Manganese-Dioxide-Coating-Instructed Plasmonic Modulation of Gold Nanorods for Activatable Duplex-Imaging-Guided NIR-II Photothermal-Chemodynamic Therapy

Ting He et al.

Summary: A plasmonic modulation strategy of gold nanorods through manganese dioxide coating has been developed for NIR-II photoacoustic/magnetic resonance imaging-guided photothermal chemodynamic therapy. The LSPR peak of gold nanorods can be tuned by adjusting the thickness of the MnO2 layer, and the MnO2 layer can degrade in the tumor microenvironment for MR imaging and chemodynamic therapy. This strategy can be applied to other metal nanomaterials for construction of a new class of NIR-II nanotheranostics.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Iron oxide nanoparticles augment the intercellular mitochondrial transfer-mediated therapy

Ting Huang et al.

Summary: Iron oxide nanoparticles (IONPs) can enhance the selective transfer of mitochondria from human mesenchymal stem cells (hMSCs) to diseased cells, promoting intercellular mitochondrial transfer and significantly mitigating fibrotic progression. The method shows potential for restoring mitochondrial bioenergetics in diseased cells.

SCIENCE ADVANCES (2021)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Biocompatible Mesoporous Silica-Polydopamine Nanocomplexes as MR/Fluorescence Imaging Agent for Light-Activated Photothermal-Photodynamic Cancer Therapy In Vivo

Jiahui Lu et al.

Summary: This study successfully designed a novel multifunctional nanocomplex with superior properties in MR imaging, photothermal conversion, and generation of reactive oxygen species. The nanocomplexes exhibited strong inhibition to the growth of MDA-MB-231 tumor in vitro and in vivo under the guidance of MR and fluorescence imaging.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Sono-Controllable and ROS-Sensitive CRISPR-Cas9 Genome Editing for Augmented/Synergistic Ultrasound Tumor Nanotherapy

Yinying Pu et al.

Summary: A sono-controllable and ROS-sensitive nanomedicine, P/M@CasMTH1, has been developed for enhanced sonodynamic therapy by disrupting MTH1 gene in tumor cells, leading to cellular apoptosis and tumor suppression.

ADVANCED MATERIALS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Supramolecular Self-Assembled DNA Nanosystem for Synergistic Chemical and Gene Regulations on Cancer Cells

Feng Li et al.

Summary: This study reports a supramolecular self-assembled DNA nanosystem that reprogrammed the cellular antioxidant system through synergistic chemical and gene regulations, significantly promoting metabolic reprogramming of cancer cells, showing great potential in cancer therapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Photodynamic therapy for hypoxic tumors: Advances and perspectives

Li Huang et al.

Summary: Photodynamic therapy (PDT) is a preferred clinical technology for treating tumors, but the hypoxic tumor microenvironment weakens its efficiency. Strategies for improving PDT efficacy in hypoxic tumors include increasing oxygen concentration, disregarding hypoxia, and exploiting hypoxia. Combining PDT with other therapeutics can also enhance treatment outcomes.

COORDINATION CHEMISTRY REVIEWS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

DNA Repair Protein APE1 Degrades Dysfunctional Abasic mRNA in Mitochondria Affecting Oxidative Phosphorylation

Arianna Barchiesi et al.

Summary: APE1 is a versatile protein involved in DNA repair, gene expression regulation, and RNA metabolism in mitochondria. Loss of APE1 leads to accumulation of damaged mitochondrial mRNA, impairing protein translation and mitochondrial respiration efficiency. The data demonstrate that APE1 plays a crucial role in maintaining mitochondrial well-being.

JOURNAL OF MOLECULAR BIOLOGY (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

A Synergistic DNA-polydopamine-MnO2 Nanocomplex for Near-Infrared-Light-Powered DNAzyme-Mediated Gene Therapy

Huaixin Zhao et al.

Summary: A DNA-polydopamine-MnO2 nanocomplex was developed for near-infrared light-powered catalytic activity of DNAzyme in vivo. The complex can enhance Egr-1 mRNA cleavage activity of DNAzyme, leading to downregulation of Egr-1 protein in tumor cells and achieving a synergistic tumor ablation effect through heat stress induction.

NANO LETTERS (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

Cancer therapeutic strategies based on metal ions

Yang Liu et al.

Summary: Metal ions play a crucial role in various physiological processes and can be utilized to effectively inhibit cancer cell growth, serving as a promising therapeutic approach with low likelihood of drug resistance.

CHEMICAL SCIENCE (2021)

添加到收藏夹

Article Chemistry, Multidisciplinary

DNA cleavage and chemical transformation of nano-plastics mediated by surface ligand and size

Yingcan Zhao et al.

Summary: This study investigated the photochemistry of nano-plastic particles with different surface ligands and sizes under a solar simulator, providing new insights into DNA cleavage and chemical transformation mediated by these factors.

CHEMICAL COMMUNICATIONS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Self-assembled single-atom nanozyme for enhanced photodynamic therapy treatment of tumor

Dongdong Wang et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of CaCO3-Based Nanomedicine for Enhanced Sonodynamic Therapy via Amplification of Tumor Oxidative Stress

Ziliang Dong et al.

CHEM (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

Chinmoy Saha et al.

SCIENCE ADVANCES (2020)

添加到收藏夹

Review Chemistry, Multidisciplinary

Multivalent Chelators for InVivo Protein Labeling

Ralph Wieneke et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Persistent Regulation of Tumor Microenvironment via Circulating Catalysis of MnFe2O4@Metal-Organic Frameworks for Enhanced Photodynamic Therapy

Sheng-Yan Yin et al.

ADVANCED FUNCTIONAL MATERIALS (2019)

添加到收藏夹

Review Nanoscience & Nanotechnology

Engineered materials for in vivo delivery of genome-editing machinery

Sheng Tong et al.

NATURE REVIEWS MATERIALS (2019)

添加到收藏夹

Review Chemistry, Inorganic & Nuclear

Metalloporphyrin nanoparticles: Coordinating diverse theranostic functions

Shuai Shao et al.

COORDINATION CHEMISTRY REVIEWS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Self-Assembling Endogenous Biliverdin as a Versatile Near-Infrared Photothermal Nanoagent for Cancer Theranostics

Ruirui Xing et al.

ADVANCED MATERIALS (2019)

添加到收藏夹

Article Chemistry, Multidisciplinary

Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2-Based Nanoagent to Enhance Chemodynamic Therapy

Li-Sen Lin et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Toward Understanding Liposome-Based siRNA Delivery Vectors: Atomic-Scale Insight into siRNA–Lipid Interactions

Alexandra Yu. Antipina et al.

LANGMUIR (2018)

添加到收藏夹

Article Chemistry, Multidisciplinary

Versatile Catalytic Deoxyribozyme Vehicles for Multimodal Imaging-Guided Efficient Gene Regulation and Photothermal Therapy

Jie Feng et al.

ACS NANO (2018)

添加到收藏夹

Review Chemistry, Multidisciplinary

Chemophototherapy: An Emerging Treatment Option for Solid Tumors

Dandan Luo et al.

ADVANCED SCIENCE (2017)

添加到收藏夹

Article Cell Biology

RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a

Ramya Sundaresan et al.

CELL REPORTS (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Structure and Dynamics of Cas9 HNH Domain Catalytic State

Zhicheng Zuo et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Fabricating MnO2 Nanozymes as Intracellular Catalytic DNA Circuit Generators for Versatile Imaging of Base-Excision Repair in Living Cells

Feng Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

添加到收藏夹

Review Biochemical Research Methods

In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges

Rubul Mout et al.

BIOCONJUGATE CHEMISTRY (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

Surfactant-Stripped Frozen Pheophytin Micelles for Multimodal Gut Imaging

Yumiao Zhang et al.

ADVANCED MATERIALS (2016)

添加到收藏夹

Article Chemistry, Multidisciplinary

Manganese Extraction Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles

Luodan Yu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

添加到收藏夹

Article Engineering, Biomedical

pH-responsive metallo-supramolecular nanogel for synergistic chemo-photodynamic therapy

Xuemei Yao et al.

ACTA BIOMATERIALIA (2015)

添加到收藏夹

Article Chemistry, Multidisciplinary

Protein Delivery System Containing a Nickel-Immobilized Polymer for Multimerization of Affinity-Purified His-Tagged Proteins Enhances Cytosolic Transfer

Viktoriia Postupalenko et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

添加到收藏夹

Article Genetics & Heredity

mRNA and miRNA expression patterns associated to pathways linked to metal mixture health effects

M. Martinez-Pacheco et al.

GENE (2014)

添加到收藏夹

Article Chemistry, Multidisciplinary

Synthesis of a pH-Sensitive Nitrilotriacetic Linker to Peptide Transduction Domains To Enable Intracellular Delivery of Histidine Imidazole Ring-Containing Macromolecules

Ronald K. June et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Structural insights into mechanisms of the small RNA methyltransferase HEN1

Ying Huang et al.

NATURE (2009)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.