4.8 Article

Targeting lactate metabolism and immune interaction in breast tumor via protease-triggered delivery

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Targeting glycolysis for cancer therapy using drug delivery systems

Yongzhuo Huang

Summary: There is a close relationship between cancer metabolism and immunity. Targeting cancer metabolism shows promise as a therapeutic approach for cancer immunotherapy. The Warburg effect, characterized by abnormal glucose metabolism, can modify cancer cells and create a suppressive immune microenvironment.

JOURNAL OF CONTROLLED RELEASE (2023)

Article Oncology

Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Shogo Kumagai et al.

Summary: In highly glycolytic tumors, regulatory T (Treg) cells have higher PD-1 expression compared to effector T cells. Under low-glucose conditions, Treg cells actively absorb lactic acid through monocarboxylate transporter 1 (MCT1), promoting the expression of PD-1, while PD-1 expression by effector T cells is dampened. PD-1 blockade invigorates PD-1-expressing Treg cells, resulting in treatment failure.

CANCER CELL (2022)

Letter Oncology

HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk

Hengyu Li et al.

Summary: Tumor-associated macrophages (TAMs) promote the activation of hepatic leukemia factor (HLF) in triple-negative breast cancer (TNBC) cells through the secretion of transforming growth factor-beta1 (TGF-beta 1) and subsequently, HLF transactivates gamma-glutamyltransferase 1 (GGT1) to enhance ferroptosis resistance. This process drives TNBC cell proliferation, metastasis, and cisplatin resistance. Additionally, TNBC cells activate the JAK2/STAT3 axis to induce TGF-beta 1 secretion by TAMs, forming a feed-forward circuit. The combination of HLF and GGT1 values can improve the accuracy of TNBC patient prognosis.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Article Chemistry, Multidisciplinary

Anti-alcoholism drug disulfiram for targeting glioma energy metabolism using BBB-penetrating delivery of fixed-dose combination

Pengfei Zhao et al.

Summary: The interplay between tumor metabolism and the immune microenvironment plays a crucial role in glioma progression. In this study, the researchers discovered that the drugs disulfiram (DSF) and shikonin (SHK) can inhibit the ATP supply pathway and glycolysis in glioma cells, leading to a reduction in ATP generation. By developing a nanoparticle system, they were able to efficiently deliver a fixed-dose combination of DSF and SHK to the glioma cells, resulting in prolonged survival in glioma mice by modulating energy metabolism and the immune microenvironment.

NANO TODAY (2022)

Article Multidisciplinary Sciences

Triple-negative breast cancer influences a mixed M1/M2 macrophage phenotype associated with tumor aggressiveness

Kristine Cate S. Pe et al.

Summary: This study evaluated the interaction between breast cancer cells and macrophages in the context of triple-negative breast cancer (TNBC). The results showed that TNBC-induced tumor-associated macrophages expressed both M1 and M2-associated genes, and secreted multiple cytokines, further enhancing tumor cell growth and aggressiveness.

PLOS ONE (2022)

Article Oncology

Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis

Tian Zhao et al.

Summary: Legumain is a newly discovered lysosomal cysteine protease that plays crucial roles in regulating immunity and cancer metastasis. Esomeprazole and omeprazole have been identified as novel legumain inhibitors, showing potential in reducing cancer cell invasion and metastasis.

INVESTIGATIONAL NEW DRUGS (2021)

Review Biochemistry & Molecular Biology

The intrinsic immunogenic properties of cancer cell lines, immunogenic cell death, and how these influence host antitumor immune responses

Tania Love Aaes et al.

Summary: Modern cancer therapies often combine cytotoxic strategies with immune activation to stimulate an antitumor response. Studying the interaction between antitumor cytotoxic therapies, cancer cells, and the immune system requires appropriate experimental tumor models. In this review, the focus is on the immunostimulatory and immunosuppressive properties of cancer cell lines used in immunogenic cell death studies.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment

Conall Hayes et al.

Summary: The tumor microenvironment plays a critical role in cancer development and progression, with lactate accumulation actively contributing to immune evasion. Measuring lactate levels in tumors has shown promise as a predictive and prognostic biomarker in various cancer types. Targeting lactate metabolism may be a priority in developing effective cancer therapies, although success in human trials has been limited so far due to the complexities of metabolic interactions.

CANCER LETTERS (2021)

Article Engineering, Biomedical

Poly(L-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

Zhongyu Jiang et al.

Summary: This study designed and prepared two kinds of PLG-CDDP nanoformulations with detachable PEG, utilizing pH(e) and MMP as trigger factors to prolong circulation time and enhance cell uptake. The smart nanoformulations showed higher antitumor efficacy in vivo, indicating promising prospects for future clinical applications.

BIOACTIVE MATERIALS (2021)

Article Biochemistry & Molecular Biology

C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system

Junxing Qu et al.

Summary: Candida tropicalis has been found to promote chemotherapy resistance in colon cancer by producing lactate and inhibiting the expression of MLH1, providing a new insight into improving the efficacy of colorectal cancer chemotherapy.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

Review Oncology

Emerging roles of aerobic glycolysis in breast cancer

Z. Wu et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2020)

Review Immunology

Antigen presentation by dendritic cells and their instruction of CD4+T helper cell responses

Kerry L. Hilligan et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Review Oncology

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Lorenzo Galluzzi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Multidisciplinary Sciences

Uncoupling DNA damage from chromatin damage to detoxify doxorubicin

Xiaohang Qiao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Oncology

Antigen processing and presentation in cancer immunotherapy

Maxwell Y. Lee et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Biochemistry & Molecular Biology

Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer

Sara El-Sahli et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Chemistry, Multidisciplinary

Nanoparticle-Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Immunology

Dendritic cells as gatekeepers of tolerance

Ari Waisman et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

Editorial Material Oncology

Lactic acid polarizes macrophages to a tumor-promoting state

Oscar R. Colegio

ONCOIMMUNOLOGY (2016)

Editorial Material Cell Biology

Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells

Kristen E. N. Scott et al.

Cell Metabolism (2016)

Article Oncology

New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin

Ana Filipa Brito et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2016)

Article Chemistry, Multidisciplinary

Pharmacokinetic strategies to improve drug penetration and entrapment within solid tumors

Ahmed M. Al-Abd et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Chemistry, Multidisciplinary

Quercetin sensitizes human glioblastoma cells to temozolomide in vitro via inhibition of Hsp27

Dong-ping Sang et al.

ACTA PHARMACOLOGICA SINICA (2014)

Article Chemistry, Multidisciplinary

Molecular-Dynamics-Simulation-Driven Design of a Protease-Responsive Probe for In-Vivo Tumor Imaging

Yifan Jiang et al.

ADVANCED MATERIALS (2014)

Article Multidisciplinary Sciences

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Oscar R. Colegio et al.

NATURE (2014)

Article Multidisciplinary Sciences

Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment

Ze Liu et al.

NATURE COMMUNICATIONS (2014)

Review Immunology

Immunogenic Cell Death in Cancer Therapy

Guido Kroemer et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 31 (2013)

Review Oncology

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?

Stephen Yiu Chuen Choi et al.

JOURNAL OF PATHOLOGY (2013)

Review Biochemistry & Molecular Biology

Tumor glycolysis as a target for cancer therapy: progress and prospects

Shanmugasundaram Ganapathy-Kanniappan et al.

MOLECULAR CANCER (2013)

Review Biochemistry & Molecular Biology

The monocarboxylate transporter familyuRole and regulation

Andrew P. Halestrap et al.

IUBMB LIFE (2012)

Review Oncology

Immunogenic cell death and DAMPs in cancer therapy

Dmitri V. Krysko et al.

NATURE REVIEWS CANCER (2012)

Article Multidisciplinary Sciences

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

Christian Stockmann et al.

NATURE (2008)