期刊
JOURNAL OF CONTROLLED RELEASE
卷 355, 期 -, 页码 730-744出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2023.02.002
关键词
Heparin; Lactoferrin; Brain cancer; Oral delivery; Angiogenesis
The conjugate of lactoferrin and heparin can attenuate angiogenic activity by binding to growth factors around the tumor tissue, and it can be orally absorbed and delivered to brain tumors through the blood-brain barrier. It inhibits angiogenesis in glioblastoma and shows potential as a new oral medication for treatment.
Glioblastoma multiforme (GBM) is a central nervous system disease with poor prognosis. Curative treatments for GBM involve chemotherapy, radiotherapy, and surgical pathways. Recently, antiangiogenic therapy through medications has been tried to slow tumor growth, but the drugs can induce side effects. To overcome these limitations, we developed a new orally absorbable form of heparin that can attenuate angiogenic activity by binding to growth factors around the tumor tissue. We conjugated lactoferrin (Lf) to heparin because Lf can be orally absorbed, and it interacts with the lactoferrin receptor (Lf-R) expressed on the intestine, blood-brain barrier (BBB), and glioma tumor masses. We successfully conjugated Lf and heparin by amide bond formation, as evidenced by advanced physicochemical properties such as pharmacokinetics and stability in acidic condition. This new material inhibited angiogenesis in vitro without toxicity. In addition, Lf-heparin administered orally to GBM orthotopic mice was absorbed in the small intestine and delivered specifically to the brain tumor by receptor transcytosis (Lf-R). Lf-heparin further attenuated angiogenesis progression in GBM orthotopic mice. Based on these results, Lf-heparin shows potential as a new oral medication for treatment of glioblastoma.
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