Nano-carrier for gene delivery and bioimaging based on pentaetheylenehexamine modified carbon dots

Article Chemistry, Physical

Structure-activity relationship of carbon nitride dots in inhibiting Tau aggregation

Yiqun Zhou et al.

Summary: Carbon nitride dots (CNDs) show structure-dependent inhibition of MAPT aggregation and hold great promise as a potential treatment for Alzheimer's disease. The polarity of CNDs is found to be related to their inhibition capacity.

CARBON (2022)

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Article Chemistry, Physical

Amine functionalized carbon quantum dots from paper precursors for selective binding and fluorescent labelling applications

Varsha Lisa John et al.

Summary: This study reports a novel synthesis route for preparing carbon quantum dots (CQDs) with customized surface functionality. By chemically modifying paper precursors and tethering amine groups on the paper substrates, CQDs with amine functional groups on the surface can be synthesized. The amine functionalization on the surface of CQDs enables their applications in DNA binding, suggesting their potential as efficient biological probes.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Physical

Drug delivery of memantine with carbon dots for Alzheimer's disease: blood-brain barrier penetration and inhibition of tau aggregation

Wei Zhang et al.

Summary: This study explored the efficacy of two types of carbon dots as nano-carriers for Alzheimer's disease therapy. The carbon dots successfully inhibited the aggregation of tau protein, demonstrating their potential for drug delivery in Alzheimer's treatment. These findings have significant implications for enhancing the delivery of drugs to target Alzheimer's pathology in the brain.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Multidisciplinary Sciences

Nanodelivery of nucleic acids

Barbara B. Mendes et al.

Summary: There is a growing need for a safe and effective method to deliver gene therapy materials, and nanomaterials offer an unprecedented opportunity to overcome these challenges. By utilizing their diverse physico-chemical properties, nanomaterials can be functionalized to selectively target specific biomolecules. The combination of gene therapies and nanoscale delivery systems has expanded the therapeutic and biomedical applications of nucleic acid therapeutics.

NATURE REVIEWS METHODS PRIMERS (2022)

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Review Chemistry, Multidisciplinary

BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment

Wenli Chen et al.

Summary: This review discusses various approaches to improve transportation of therapeutic agents to the CNS, focusing on the advantages of using BBB-crossing AAVs as gene delivery vectors and the different types of BBB-AAV vectors that have been developed for potential applications in CNS diseases.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Medicine, Research & Experimental

Non-Viral Vector-Mediated Gene Therapy for ALS: Challenges and Future Perspectives

Gayathri R. Ediriweera et al.

Summary: ALS is a devastating neurodegenerative disease with no effective treatment available. Recent advances in gene therapy offer hope for controlling the disease through non-viral vectors transferring genes into neurons for stable, long-term gene expression without immunological complications. Despite challenges, the future looks promising with emerging technologies and increased interest in non-viral vector-delivered gene therapy for ALS.

MOLECULAR PHARMACEUTICS (2021)

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Review Pharmacology & Pharmacy

Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects

Hui Zu et al.

Summary: Although non-viral vectors in gene therapy have low cytotoxicity and immunogenicity, they still face challenges in gene transfer efficiency, specificity, gene expression duration, and safety. Overcoming these obstacles is necessary to enhance the effectiveness of non-viral vectors in gene therapy.

AAPS JOURNAL (2021)

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Review Nanoscience & Nanotechnology

Carbon Dots: A Future Blood-Brain Barrier Penetrating Nanomedicine and Drug Nanocarrier

Wei Zhang et al.

Summary: Nanoparticles, especially carbon dots, show unprecedented potential for drug delivery across the blood-brain barrier, offering hope for treating central nervous system diseases. With abundant functional groups on their surface, they can conjugate with diverse drugs to form versatile drug nanocarriers.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Chemistry, Physical

Metformin derived carbon dots: Highly biocompatible fluorescent nanomaterials as mitochondrial targeting and blood-brain barrier penetrating biomarkers

Emel Kirbas Cilingir et al.

Summary: This study synthesized metformin derived carbon dots (Met-CDs) with low toxicity and excellent biocompatibility, making them ideal candidates for bioimaging studies. Furthermore, Met-CDs were shown to penetrate cell membranes and localize in the nucleus and mitochondria, with potential selective targeting of cancer cell mitochondria. Zebrafish study confirmed Met-CDs crossing the blood-brain barrier without additional ligands.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2021)

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Review Materials Science, Multidisciplinary

Research progress in the use of cationic carbon dots for the integration of cancer diagnosis with gene treatment

Lin-jun Yue et al.

Summary: Researchers have found that cationic carbon dots, obtained from carbon dots and amino-containing cationic compounds, exhibit potential advantages in targeted fluorescence imaging of cancers and gene therapy. Through specific preparation methods, these CCDs show good biocompatibility and fluorescence performance for use in cancer detection and treatment.

NEW CARBON MATERIALS (2021)

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Article Chemistry, Multidisciplinary

rAAV-Mediated Overexpression of SOX9 and TGF-β via Carbon Dot-Guided Vector Delivery Enhances the Biological Activities in Human Bone Marrow-Derived Mesenchymal Stromal Cells

Weikun Meng et al.

NANOMATERIALS (2020)

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Article Nanoscience & Nanotechnology

Carbon Dots Enable Efficient Delivery of Functional DNA in Plants

Bo Wang et al.

ACS APPLIED BIO MATERIALS (2020)

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Article Chemistry, Physical

Halloysite nanotubes-carbon dots hybrids multifunctional nanocarrier with positive cell target ability as a potential non-viral vector for oral gene therapy

Marina Massaro et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Chemistry, Physical

Carbon dot-DNA-protoporphyrin hybrid hydrogel for sustained photoinduced antimicrobial activity

Sonam Kumari et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Biochemical Research Methods

Carbon Nitride Dots: A Selective Bioimaging Nanomaterial

Piumi Y. Liyanage et al.

BIOCONJUGATE CHEMISTRY (2019)

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Article Chemistry, Physical

Effect of lipid chain length on nanostructured lipid carriers: Comprehensive structural evaluation by scattering techniques

Rohini Kanwar et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2019)

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Article Chemistry, Multidisciplinary

Praseodymium promotes B-Z transition in self-assembled DNA nanostructures

Madhabi M. Bhanjadeo et al.

RSC ADVANCES (2019)

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Article Chemistry, Multidisciplinary

Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood-brain barrier and inhibitors of β-amyloid

Yiqun Zhou et al.

NANOSCALE (2019)

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Review Engineering, Biomedical

Recent advances in the development of gene delivery systems

Y. K. Sung et al.

BIOMATERIALS RESEARCH (2019)

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Article Chemistry, Physical

Exploring the binding of carbon dots to calf thymus DNA: From green synthesis to fluorescent molecular probe

Chun-Yan Liang et al.

CARBON (2018)

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Review Pharmacology & Pharmacy

Carbon dots: emerging theranostic nanoarchitectures

Vijay Mishra et al.

DRUG DISCOVERY TODAY (2018)

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Article Engineering, Chemical

Citric Acid-Assisted Synthesis of Nanoparticle Copper Catalyst Supported on an Oxide System for the Reduction of Furfural to Furfuryl Alcohol in the Vapor Phase

N. J. Venkatesha et al.

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2018)

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Article Biochemistry & Molecular Biology

Binding Interactions of Zinc Cationic Porphyrin with Duplex DNA: From B-DNA to Z-DNA

Tingxiao Qin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Chemistry, Multidisciplinary

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

Martin P. Stewart et al.

CHEMICAL REVIEWS (2018)

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Article Chemistry, Physical

One-step synthesis of photoluminescent carbon dots with excitation independent emission for selective bioimaging and gene delivery

Xudong Yang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2017)

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Article Chemistry, Physical

Gel-like Carbon Dots: Characterization and their Potential Applications

Yiqun Zhou et al.

CHEMPHYSCHEM (2017)

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Article Chemistry, Physical

Gene delivery using calcium phosphate nanoparticles: Optimization of the transfection process and the effects of citrate and poly(L-lysine) as additives

Mohammed A. Khan et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2016)

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Article Chemistry, Multidisciplinary

Non-viral gene therapy: Gains and challenges of non-invasive administration methods

Marianna Foldvari et al.

JOURNAL OF CONTROLLED RELEASE (2016)

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Article Chemistry, Multidisciplinary

Genetically engineered mesenchymal stem cell therapy using self-assembling supramolecular hydrogels

Byung Woo Hwang et al.

JOURNAL OF CONTROLLED RELEASE (2015)

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Article Chemistry, Physical

Multifunctional carbon dots with high quantum yield for imaging and gene delivery

Liming Hu et al.

CARBON (2014)

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Article Biochemistry & Molecular Biology

Lighting up left-handed Z-DNA: photoluminescent carbon dots induce DNA B to Z transition and perform DNA logic operations

Lingyan Feng et al.

NUCLEIC ACIDS RESEARCH (2013)

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Article Spectroscopy

Synthesis, characterization, biological screenings and interaction with calf thymus DNA of a novel azomethine 3-((3,5-dimethylphenylimino)methyl)benzene-1,2-diol

Muhammad Sirajuddin et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2012)

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Article Biotechnology & Applied Microbiology

Rational design of cationic lipids for siRNA delivery

Sean C. Semple et al.

NATURE BIOTECHNOLOGY (2010)

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Review Chemistry, Multidisciplinary

Nonviral Vectors for Gene Delivery

Meredith A. Mintzer et al.

CHEMICAL REVIEWS (2009)

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Article Chemistry, Analytical

Electrochemical studies and spectroscopic investigations on the interaction of an anticancer drug with DNA and their analytical applications

Shankara S. Kalanur et al.

JOURNAL OF ELECTROANALYTICAL CHEMISTRY (2009)

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Article Chemistry, Physical

One-step synthesis of fluorescent carbon nanoparticles by laser irradiation

Sheng-Liang Hu et al.

JOURNAL OF MATERIALS CHEMISTRY (2009)

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Article Biotechnology & Applied Microbiology

Artificial viruses: a nanotechnological approach to gene delivery

E Mastrobattista et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

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Review Chemistry, Physical

Polymers for gene delivery across length scales

David Putnam

NATURE MATERIALS (2006)

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Article Biotechnology & Applied Microbiology

Gene therapy for hepatocellular carcinoma using sonoporation enhanced by contrast agents

Y Sakakima et al.

CANCER GENE THERAPY (2005)

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Review Biotechnology & Applied Microbiology

Design and development of polymers for gene delivery

DW Pack et al.

NATURE REVIEWS DRUG DISCOVERY (2005)

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Article Optics

Photoporation and cell transfection using a violet diode laser

L Paterson et al.

OPTICS EXPRESS (2005)

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Review Chemistry, Multidisciplinary

Genetically engineered polymers: status and prospects for controlled release

M Haider et al.

JOURNAL OF CONTROLLED RELEASE (2004)

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Article Biochemistry & Molecular Biology

Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo

F Scherer et al.

GENE THERAPY (2002)

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Article Chemistry, Multidisciplinary

Thin films of hydroxy-TEMPO-substituted TTF and of its charge-transfer complex with TCNQ

H Casellas et al.

NEW JOURNAL OF CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

Development of formulations that enhance physical stability of viral vectors for gene therapy

MA Croyle et al.

GENE THERAPY (2001)

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Article Biochemistry & Molecular Biology

Particle-mediated gene transfer into murine livers using a newly developed gene gun

S Kuriyama et al.

GENE THERAPY (2000)

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Nano-carrier for gene delivery and bioimaging based on pentaetheylenehexamine modified carbon dots

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