4.7 Article

Magrolimab in Combination With Azacitidine in Patients With Higher-Risk Myelodysplastic Syndromes: Final Results of a Phase Ib Study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Oncology

BMT for Myelodysplastic Syndrome: When and Where and How

Akriti G. Jain et al.

Summary: Myelodysplastic syndromes (MDS) are a group of hematological malignancies characterized by bone marrow failure and the risk of leukemic transformation. Multiple prognostic models have been developed to predict survival and leukemic transformation. Allogeneic blood or marrow transplant (alloBMT) is the only curative treatment for MDS, but its historically high rates of toxicity and transplant-related mortality (TRM) limit its use. However, with modern techniques, alloBMT has become a suitable option even for older or comorbid patients. Therefore, early transplant evaluation and consideration of the potential benefits of transplant are crucial in MDS patients.

FRONTIERS IN ONCOLOGY (2022)

Article Hematology

A randomized phase 2 trial of azacitidine with or without durvalumab as first-line therapy for higher-risk myelodysplastic syndromes

Amer M. Zeidan et al.

Summary: This study conducted a randomized phase 2 trial comparing the efficacy of Azacitidine plus Durvalumab with Azacitidine monotherapy in the treatment of higher-risk myelodysplastic syndromes. The results showed that the combination therapy did not significantly improve clinical outcomes and was associated with more toxicities.

BLOOD ADVANCES (2022)

Review Oncology

SOHO State of the Art and Next Questions: Treatment of Higher-Risk Myelodysplastic Syndromes

Brandon J. Aubrey et al.

Summary: Higher-risk myelodysplastic syndromes (MDS) have a poor prognosis, with rapid disease progression, impact on quality of life, high risk of transformation to acute myeloid leukemia (AML), and low long-term survival rate. Allogeneic hematopoietic stem cell transplant (HCT) is the only curative therapy, while treatment with hypomethylating agent chemotherapy, azacitidine or decitabine, is the main palliative option. Novel targeted therapies are being developed in clinical trials and offer hope for new treatment options.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2022)

Article Hematology

Pevonedistat plus azacitidine vs azacitidine alone in higher-risk MDS/chronic myelomonocytic leukemia or low-blast-percentage AML

Lionel Ades et al.

Summary: The study compared the efficacy of pevonedistat+azacitidine to azacitidine monotherapy in patients with newly diagnosed higher-risk myelodysplastic syndromes and found that in certain patient populations, the new treatment may yield better clinical outcomes, while continued therapy could potentially improve survival.

BLOOD ADVANCES (2022)

Article Hematology

Baseline and serial molecular profiling predicts outcomes with hypomethylating agents in myelodysplastic syndromes

Anthony M. Hunter et al.

Summary: Baseline and sequential molecular profiling by NGS is valuable in identifying patients likely to benefit from HMAs in MDS treatment, particularly in cases with TP53 mutations. TET2 mutation and ASXL1 wild-type genotype are the strongest predictors of treatment response, while TP53 and EZH2 mutations are associated with inferior prognosis.

BLOOD ADVANCES (2021)

Review Oncology

A systematic review of higher-risk myelodysplastic syndromes clinical trials to determine the benchmark of azacitidine and explore alternative endpoints for overall survival

Jacqueline S. Garcia et al.

Summary: Azacitidine can prolong overall survival in high-risk MDS patients, but the contribution of novel therapies added to azacitidine remains unclear due to varying study outcomes. There is a discrepancy between response rates and overall survival improvement with azacitidine, making reliance on earlier endpoints challenging. More data and larger studies are needed to better understand the treatment outcomes and correlations between different parameters in HR-MDS patients treated with azacitidine.

LEUKEMIA RESEARCH (2021)

Article Hematology

Phase II study of azacitidine with pembrolizumab in patients with intermediate-1 or higher-risk myelodysplastic syndrome

Kelly S. Chien et al.

Summary: The study showed that PD-1 and PD-L1 expression is upregulated in CD34(+) bone marrow cells of MDS patients and combining azacitidine with pembrolizumab had a significant overall response rate of 76% in previously untreated patients. However, the combination therapy had a lower response rate in patients who had failed HMA treatment. Adverse events, such as pneumonia and arthralgias, were common, but manageable, with corticosteroids required in 43% of cases.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Oncology

Biologic Assignment Trial of Reduced-Intensity Hematopoietic Cell Transplantation Based on Donor Availability in Patients 50-75 Years of Age With Advanced Myelodysplastic Syndrome

Ryotaro Nakamura et al.

Summary: The study compared allogeneic hematopoietic cell transplantation (HCT) with other treatments for patients aged 50-75 with intermediate-2 or high-risk de novo MDS, and found that HCT with a matched donor significantly improved 3-year overall survival rate and leukemia-free survival rate.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Medicine, General & Internal

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma

Ranjana Advani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Hematology

Myelodysplastic syndromes: 2018 update on diagnosis, risk-stratification and management

Guillermo Montalban-Bravo et al.

AMERICAN JOURNAL OF HEMATOLOGY (2018)

Article Multidisciplinary Sciences

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

Diane Tseng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes

Wendy W. Pang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Immunology

The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications

Mark P. Chao et al.

CURRENT OPINION IN IMMUNOLOGY (2012)

Article Oncology

Characteristics of US Patients with Myelodysplastic Syndromes: Results of Six Cross-sectional Physician Surveys

Mikkael A. Sekeres et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2008)

Article Multidisciplinary Sciences

Role of CD47 as a marker of self on red blood cells

PA Oldenborg et al.

SCIENCE (2000)