期刊
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
卷 67, 期 -, 页码 426-434出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jtice.2016.07.027
关键词
Hydrogels; Nanocomposites; Kappa-carrageenan; Halloysite nanotube; In vitro drug release
资金
- Universiti Teknologi Malaysia from the Ministry of Education Malaysia [R.J130000.7809.4F546]
Novel kappa-carrageenan (Kc)/halloysite nanotube (HNT) nanocomposite hydrogels were synthesized via physical crosslinking for the gastro-intestinal tract (GIT) release. The influence of HNT nanoparticle content on Kc/HNT hydrogel properties such as thermal, swelling, drug loading and in vitro release was examined. Thermal results revealed that the incorporation of HNT nanoparticles enhanced the thermal stability of the nanocomposite hydrogels. Also, the nanocomposite hydrogels showed higher swelling, drug loading and release behavior compared to the pure Kc hydrogel. In vitro release from the Kc-HNT hydrogels exhibited that rhodamine B (RB), a cationic model drug, released higher than orange G (OG), an anionic model drug. RB in vitro release from the nanocomposite hydrogels reached to approximately 72%, while 54% of OG was released. Finally, in vitro cytotoxicity test revealed that both Kc and Kc-HNT hydro-gels are biocompatible. Taking together, it was shown that Kc-HNT hydrogels may have a great potential applications in oral drug delivery systems. (C) 2016 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据