Irish funder guidance increased searching for, and uptake of, core outcome sets

Article Health Care Sciences & Services

In-depth qualitative interviews identified barriers and facilitators that influenced chief investigators' use of core outcome sets in randomised controlled trials

Karen L. Hughes et al.

Summary: This study aimed to investigate barriers and facilitators to the uptake of core outcome sets (COS) in randomized controlled trials. Based on qualitative interviews with UK chief investigators, facilitators to uptake include investigator behavior and the wider research system, while barriers to uptake include perceived characteristics of COS and issues in the COS development process. Recommendations to improve COS uptake include engagement with the research community, involving patients in COS development, and ensuring COS remain up to date.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2022)

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Article Medicine, Research & Experimental

Getting it wrong most of the time? Comparing trialists' choice of primary outcome with what patients and health professionals want

Shaun Treweek et al.

Summary: The primary outcome in a trial is considered the most important piece of data collected, as it is used to assess the effectiveness of interventions. In this study, patients and healthcare professionals agreed with the choice of primary outcome in late-stage trials for breast cancer management and nephrology 28% of the time.

TRIALS (2022)

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Review Health Care Sciences & Services

Review finds core outcome set uptake in new studies and systematic reviews needs improvement

Paula R. Williamson et al.

Summary: This article reviews the uptake of core outcome sets (COS) and finds that it is generally low in most research areas. Common facilitators include trialist awareness and understanding, while common barriers include not involving all relevant specialties in the development process and a lack of recommendations for outcome measurement. Increasingly, organizations are recommending the consideration of COS.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2022)

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Review Health Care Sciences & Services

A systematic review finds Core Outcome Set uptake varies widely across different areas of health

Karen L. Hughes et al.

Summary: This review aimed to assess the uptake of core outcome sets (COS) in randomized controlled trials (RCTs) and systematic reviews (SRs) across different areas of health. The results showed that there is a wide variation in the uptake of COS, with barriers including lack of validated measures and involvement of key stakeholders. Further studies are needed to explore the implementation of COS in a wider range of disease categories and to identify barriers and facilitators to uptake.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2021)

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Article Public, Environmental & Occupational Health