Another Option for Aggression and Self-Injury, Alternative Benzodiazepines for Catatonia in Profound Autism

Letter Psychology, Developmental

Morbidity Due to Disparity in Pediatric Electroconvulsive Therapy

Michael Ong et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2023)

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Letter Pediatrics

Letter to the Editor: Aripiprazole-Induced Hypersexuality in an Autistic Child

Joshua R. Smith et al.

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY (2022)

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Article Pediatrics

Crossing State Lines: Ethical and Clinical Considerations in Treating a Child With Catatonia

Jeremy Miller et al.

JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY (2022)

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Review Medicine, General & Internal

The Lancet Commission on the future of care and clinical research in autism

Catherine Lord et al.

Summary: Autism is a globally important condition affecting individuals and families worldwide. Although awareness has increased significantly in the past 20 years, more work is needed to improve life outcomes for individuals with autism. This requires investments in practical clinical research and the establishment of social and service systems that recognize the potential for change and growth, and address the diverse and complex needs of individuals with autism and their families.

LANCET (2022)

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Review Medicine, General & Internal

Electroconvulsive Therapy

Randall T. Espinoza et al.

Summary: Update on Electroconvulsive Therapy (ECT): ECT is effective for several disorders, notably severe or treatment-resistant depression, showing rapid response. However, stigma hampers its usage. The mechanism remains unknown, but a seizure is necessary for efficacy. ECT prominently affects memory, albeit transiently.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Review Clinical Neurology

Biomarkers Obtained by Transcranial Magnetic Stimulation in Neurodevelopmental Disorders

Ali Jannati et al.

Summary: Transcranial magnetic stimulation (TMS) is a method for focal brain stimulation using electromagnetic induction in adults. It includes various protocols and neurophysiological measurements for analyzing neurodevelopmental disorders.

JOURNAL OF CLINICAL NEUROPHYSIOLOGY (2022)

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Article Genetics & Heredity

Globally elevated excitation-inhibition ratio in children with autism spectrum disorder and below-average intelligence

Viktoriya O. Manyukhina et al.

Summary: This study investigates the excitation-inhibition (E-I) balance in large neuronal populations in children with Autism Spectrum Disorder (ASD) and below-average IQ. The flattened spectral slope of aperiodic activity suggests a shift towards hyper-excitation in individuals with ASD and intellectual disability. These findings provide insight into the relationship between ASD and intellectual disability, and offer a potential biomarker for evaluating treatment effectiveness.

MOLECULAR AUTISM (2022)

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Article Psychology, Developmental

Use of ECT in Autism Spectrum Disorder and/or Intellectual Disability: A Single Site Retrospective Analysis

Joshua R. Smith et al.

Summary: Autism spectrum disorder (ASD) and intellectual disability (ID) are prevalent and heterogeneous conditions, often comorbid with psychiatric disorders. Research on electroconvulsive therapy (ECT) in these patients has shown positive results, indicating the need for further investigation in this population.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2022)

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Review Psychology, Clinical

Treatment Response of Transcranial Magnetic Stimulation in Intellectually Capable Youth and Young Adults with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Joshua R. Smith et al.

Summary: This study conducted a meta-analysis of clinical trials investigating the use of transcranial magnetic stimulation (TMS) in the treatment of intellectually capable persons with autism spectrum disorder (IC-ASD). The results showed that low frequency repetitive TMS to the dorsolateral prefrontal cortex was associated with improvement in cognitive outcomes and symptomology of IC-ASD. However, further research with neuronavigation software, theta burst protocols, targeting of various brain regions, and robust study design is needed.

NEUROPSYCHOLOGY REVIEW (2022)

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Editorial Material Psychology, Developmental

Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder

Erin Henneberry et al.

Summary: Drug treatment research in autism spectrum disorder (ASD) has made significant progress in recent decades, particularly in improving the ability to treat behavioral challenges. However, there are still unmet medical needs, such as the lack of approved drug therapies for the core symptoms of autism.

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS (2021)

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Review Psychiatry

Catatonia in autism spectrum disorders: A systematic review and meta-analysis

J. Vaquerizo-Serrano et al.

Summary: Catatonic features can appear in individuals with autism spectrum disorders (ASDs), affecting around 10.4% of ASD patients, commonly males. Treatment options include benzodiazepines, antipsychotics, and electroconvulsive therapy (ECT) with promising results in managing catatonic symptoms. Longitudinal studies are needed to further understand the relationship between catatonia and ASD.

EUROPEAN PSYCHIATRY (2021)

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Article Psychiatry

Case Report: A Case of Pediatric Catatonia: Role of the Lorazepam Challenge Test

Laura Ridgeway et al.

Summary: This case demonstrates that even with a negative lorazepam challenge test, subsequent benzodiazepine treatment may still be effective in managing catatonic symptoms.

FRONTIERS IN PSYCHIATRY (2021)

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Article Behavioral Sciences

Importance of Trauma-Informed Practice in Evaluation of Children Diagnosed with Autism Spectrum Disorder

Adam Langenfeld et al.

Summary: Erin went through the process of adoption, foster care and receiving different therapies during her early years, showing progress and improvement. However, her parents are skeptical of her initial diagnoses and seek a more accurate diagnostic plan.

JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS (2021)

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Article Psychiatry

Revisiting lorazepam challenge test: Clinical response with dose variations and utility for catatonia in a psychiatric emergency setting

Hari Hara Suchandra et al.

Summary: This study aimed to compare the response between two groups receiving different Lorazepam challenge test (LCT) doses in catatonia patients. Results suggest that 2 mg Lorazepam may be an optimal LCT dose, showing significant response to most catatonic signs. This offers direction for standardizing lorazepam dosing schedules for catatonia management and exploring neurobiological underpinnings for individual catatonic signs.

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2021)

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Article