☆ 4.7 Article

Illuminating the Chemical Space of Untargeted Proteins

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

InterPro in 2022

Typhaine Paysan-Lafosse et al.

Summary: The InterPro database has been updated with new data content and website features, providing a more user-friendly access to protein sequence classification and functional domain identification. It has also integrated features from the retiring Pfam website and developed a card game to engage the non-scientific community. Furthermore, the database explores the benefits and challenges of using artificial intelligence for protein structure prediction.

NUCLEIC ACIDS RESEARCH (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

RCSB Protein Data Bank: Celebrating 50 years of the PDB with new tools for understanding and visualizing biological macromolecules in 3D

Stephen K. Burley et al.

Summary: RCSB PDB, funded by several US government agencies, has been providing service to structural biologists and PDB data consumers worldwide since 1999. It is a founding member of the worldwide Protein Data Bank partnership, serving as the US data center for the global PDB archive. RCSB PDB also develops new tools and features for 3D structure analysis and visualization.

PROTEIN SCIENCE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

AlphaFold illuminates half of the dark human proteins

Jessica L. Binder et al.

Summary: This paper investigates the use of confidence scores to evaluate the accuracy of AlphaFold protein models for drug discovery. It proposes criteria for useful models and residues and presents findings on the effects of disorder and sequence divergence on accuracy.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2022)

添加到收藏夹

Article Cell Biology

Systematic illumination of druggable genes in cancer genomes

Junjie Jiang et al.

Summary: By integrating multiple druggable genome resources, researchers identified a group of potential druggable genes and analyzed their expression, genomic alterations, cancer dependencies, and therapeutic potentials. The study revealed a significant number of reliably expressed potential druggable genes in major adult cancers, including some understudied genes, providing new opportunities for cancer treatment.

CELL REPORTS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Computational Prediction of Compound-Protein Interactions for Orphan Targets Using CGBVS

Chisato Kanai et al.

Summary: This study explores the application of chemical genomics-based virtual screening (CGBVS) in predicting ligands for orphan targets, with results showing that protein descriptors using Multiple Sequence Alignment (MSA) performed well in overall prediction accuracy. It was also found that the accuracy of ligand prediction depends on the amount of ligand information related to GPCRs associated with the target.

MOLECULES (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

DrugCentral 2021 supports drug discovery and repositioning

Sorin Avram et al.

Summary: DrugCentral is a public resource that offers up-to-date drug information, including newly approved drug ingredients, molecular entities related to COVID19, pharmacokinetic properties of drugs, sex-based separation of side effects, drug repositioning prioritization scheme, and machine learning platform for estimating anti-SARS-CoV-2 activities. Additionally, it provides a feature called 'drugs in news' for listing the most interesting drugs at the present moment.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

TCRD and Pharos 2021: mining the human proteome for disease biology

Timothy K. Sheils et al.

Summary: The NIH's IDG program aims to study poorly characterized proteins that can be modulated using small molecules or biologics. The program has produced the Target Central Resource Database (TCRD) and Pharos, which aggregate data from multiple sources and rank targets based on data availability, in machine learning ready format. Integrated data include protein interactions, disease associations, and gene signatures, among others, enabling new visualizations and sections to empower users in exploring the druggable genome.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Exploring the dark genome: implications for precision medicine

Tudor I. Oprea

MAMMALIAN GENOME (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

ChEMBL: towards direct deposition of bioassay data

David Mendez et al.

NUCLEIC ACIDS RESEARCH (2019)

添加到收藏夹

Review Pharmacology & Pharmacy

The G protein-coupled receptors deorphanization landscape

Celine Laschet et al.

BIOCHEMICAL PHARMACOLOGY (2018)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Unexplored therapeutic opportunities in the human genome

Tudor I. Oprea et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Article Chemistry, Medicinal

ZINC 15-Ligand Discovery for Everyone

Teague Sterling et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)

添加到收藏夹

Review Pharmacology & Pharmacy

International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands

Anthony P. Davenport et al.

PHARMACOLOGICAL REVIEWS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

β-arrestin- but not G protein-mediated signaling by the decoy receptor CXCR7

Sudarshan Rajagopal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

添加到收藏夹

Review Pharmacology & Pharmacy

Alternative drug discovery approaches for orphan GPCRs

Angelique Levoye et al.

DRUG DISCOVERY TODAY (2008)

添加到收藏夹

Letter Biotechnology & Applied Microbiology

Data completeness -: the Achilles heel of drug-target networks

Jordi Mestres et al.

NATURE BIOTECHNOLOGY (2008)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Relating protein pharmacology by ligand chemistry

Michael J. Keiser et al.

NATURE BIOTECHNOLOGY (2007)

添加到收藏夹

Article Chemistry, Medicinal

Ligand-based approach to in silico pharmacology:: nuclear receptor profiling

Jordi Mestres et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Do orphan G-protein-coupled receptors have ligand-independent functions? New insights from receptor heterodimers

Angelique Levoye et al.

EMBO REPORTS (2006)

添加到收藏夹

Review Genetics & Heredity

Chemogenomics: An emerging strategy for rapid target and drug discovery

M Bredel et al.

NATURE REVIEWS GENETICS (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

C5L2, a nonsignaling C5A binding protein

S Okinaga et al.

BIOCHEMISTRY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.