期刊
JOURNAL OF CHEMICAL EDUCATION
卷 100, 期 5, 页码 1973-1979出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jchemed.2c01111
关键词
Upper-Division Undergraduate; Analytical Chemistry; Lasers; Mass Spectrometry; Quantitative Analysis
A new experiment involving LA-ICP-MS was designed for chemistry undergraduate students, providing them with information on the amount and distribution of elements in a sample. Using a thin section of mouse tissue as a model sample, the students determined the distribution and quantity of essential elements Zn, Cu, and Pt.
A new experiment using laser ablation with inductively coupled plasma mass spectrometry (LA-ICP-MS) was designed for chemistry undergraduate students. While most analytical methods only provide information on the amount of the analyte, LA-ICP-MS allows extra information on the distribution of the element in the sample. Because it achieves excellent limits of detection (sub mu g center dot g-1) and high spatial resolution (micrometer scale), it is a powerful technique for imaging any sample. A thin section of mouse tissue was used as a model sample to demonstrate these abilities. The student's task was to determine the distribution of the essential elements Zn, Cu, and Pt (Pt introduced into the tumor tissue from the cytostatic drug (cis Pt)) and quantify their amount.
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