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Article
Neurosciences
Helen J. Sable et al.
Summary: The study compared the effects of a high-fat, high-sucrose Western diet with a plant-based, low-fat Daniel Fast diet on rats' spatial working memory. The results showed that the rats on the Daniel Fast diet with exercise had the best performance, highlighting the benefits of plant-based diet and chronic aerobic exercise on memory and neuroprotection. The study also emphasized the importance of carefully designing exercise regimens when implementing dietary changes to avoid negative effects.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Orthopedics
Yannick Delpierre
Summary: This study aimed to evaluate the influence of fear-avoidance beliefs, anxiety, and depression on dynamic and motor control parameters before and after the Functional Restoration Program. The results showed that patients exhibited different patterns in preferred walking speed, capacity benefit, peaks of propulsion, and gait stability based on clinical scores. Fear-avoidance beliefs, anxiety, and depression influenced the biomechanics of overground walking, and different ways of adapting gait were observed based on biopsychosocial scores. The Functional Restoration Program had an impact on these patterns.
JOURNAL OF ORTHOPAEDICS
(2022)
Article
Oncology
Hui Li et al.
Summary: Relapse and drug resistance are major causes of mortality in small-cell lung cancer patients. Intratumoral heterogeneity (ITH) is a key biological mechanism that leads to relapse and drug resistance. This study found that phenotypic plasticity plays an important role in SCLC ITH, and CSF2 may regulate phenotypic plasticity through the phosphorylated STAT3/MYC pathway.
Review
Plant Sciences
Ping Yang et al.
Summary: Studies have shown that Aucubin can improve symptoms or prognosis in various neurological diseases such as Parkinson's disease, Alzheimer's disease, intracerebral haemorrhage, diabetic encephalopathy, epilepsy, anxiety and depression, and traumatic brain injury. The mechanisms involved include increasing GABA content, promoting neural precursor cells differentiation, providing antioxidant and anti-neuroinflammation activities, and enhancing autophagy and anti-apoptotic actions.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Psychology, Clinical
Marcel Wilhelm et al.
Summary: This study presents a treatment manual for depression utilizing expectation-focused psychotherapeutic interventions (EFPI). The manual comprises psychoeducation, behavioral experiments, and cognitive immunization strategies to improve the effectiveness of cognitive behavioral therapy (CBT). A pilot study with promising results has been conducted and a comprehensive evaluation is underway.
Review
Clinical Neurology
Amanda Larosa et al.
Summary: Understanding individual variability in the development of stress-related psychopathologies is crucial for studying their neurobiology. This article focuses on the hippocampus, which is highly influenced by chronic stress and is linked to disorders like depression and post-traumatic stress disorder. The article outlines animal models used to categorize animals into susceptible and resilient groups, and reviews molecular and functional markers in the hippocampus associated with susceptibility and resilience. The authors propose that the hippocampus plays a key role in how animals with different stress susceptibilities process and store stress-related information, and these markers can potentially be targeted for new treatments.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Jing Li et al.
Summary: The study suggests that activation of LXRs may reverse depressive-like behaviors and alleviate neuroinflammation and microglial abnormalities induced by CUS. These findings indicate that regulating the number, activated state, and morphology of microglia in hippocampal subregions might be an important basis for the antidepressant effects of LXRs.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Plant Sciences
Jia-lei Fu et al.
Summary: The study uncovered the role of HDGF in the interaction between TAMs and NSCLC cells, and evaluated the anti-tumor effects of MTE on the vicious crosstalk between TAMs and NSCLC by targeting HDGF.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Zhongmei He et al.
Summary: This study investigates the antidepressant effects of AFR using network pharmacology and verification experiments. The results show that AFR has potential as a candidate for developing drugs for depression treatment.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Impyo Lee et al.
Summary: In this study, we found that TNF receptor-associated factor 2 (TRAF2) regulates the protein stability of HIPK2 by promoting proteasomal degradation. TRAF2 can decrease the protein level of HIPK2 and shorten its half-life. Furthermore, TNFa treatment induces dissociation of TRAF2 from HIPK2, leading to the accumulation of HIPK2 protein.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Immunology
Maria Fernanda Serna-Rodriguez et al.
Summary: Depression is a mental disorder characterized by sadness and loss of interest. It is influenced by genetic background, early life abuse, life stressors, and inflammatory profiles. Inflammatory activation may trigger and maintain depression, with crosstalk between the peripheral immune system and the central nervous system playing a role.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Plant Sciences
Dan Xue et al.
Summary: This study aimed to evaluate the efficacy of Traditional Chinese Medicine (TCM) tonic prescriptions on depression and construct a core TCM tonic prescription, Jianpi Tongmai formula (JPTMF), through a progressive analysis. Network pharmacology and animal experiments verified the reliability of JPTMF. The proposal of JPTMF is of innovative significance and may provide far-reaching implications for improving depression by using nourishing herbs. The integrated methods applied in this study provide an innovative paradigm for the standardization and scientific basis of TCM research.
Article
Pharmacology & Pharmacy
Xiaoxue Li et al.
Summary: This study found that overexpression of SIRT6 can alleviate renal interstitial fibrosis and improve renal function in chronic kidney disease. Further experiments showed that SIRT6 plays a role in renal fibrogenesis by inhibiting the expression of HIPK2. Population studies also revealed that higher dietary intake of vitamin B3 is associated with a lower risk of renal function decline in older individuals.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Bin Li et al.
Summary: This study investigated the dynamic changes of monocytes, macrophages, and related cytokines in animal models of persistent infection of E. multilocularis. The results showed significant liver lesions in the later stages of infection, decreased proportion of Ly6C(hi) monocytes in the peripheral blood, and fluctuating levels of Ly6C(1o) monocytes. The expression of CX3CL1, CX3CR1, CD11b, CD163, and iNOS in the liver increased, along with increased levels of TNF-alpha and Argl mRNA. Furthermore, the levels of IFN-gamma, IL-17, IL-4, and IL-10 in peripheral blood increased with the duration of infection.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Clinical Neurology
Liu Ruilian et al.
Summary: The study investigated the protective effect and mechanism of H2S-mediated aerobic exercise on the antagonism of the hippocampus inflammatory response in CUMS-depressed mice. The results showed that aerobic exercise and H2S-enhanced mice improved depressive symptoms, decreased proinflammatory factors, and increased anti-inflammatory factors.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Behavioral Sciences
Parker Knight et al.
Summary: Female rats exhibit less anxiety-like behavior in the EPM and LOF tests, with sex differences present in almost all behavioral parameters. Additionally, there is a moderate positive correlation between parameters in the EPM and LOF tests.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Youyang Zhang et al.
Summary: The study demonstrated that HUC-MSCs have cardioprotective and potential anti-depressive effects induced by MI. These effects are related to the inflammation improved by regulating Jmjd3 and microglial polarization.
PSYCHOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiping Li et al.
Summary: This study demonstrates that Edaravone (EDA) can improve neurobehavioral functions and alleviate neuroinflammation in a rat model of Parkinson's disease by inhibiting NLRP3 inflammasome activation and regulating microglia M1/M2 polarization.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Chi-Lam Poon et al.
Summary: The study found that cerebrovascular disease and major depression can lead to detectable changes in gene expression in non-diseased tissues, possibly a result of the long-term effects of diseases, lifestyles, and environmental factors. Pathways associated with immunological events were enriched in tissues associated with CVD, while neurological and metabolic pathways were enriched in tissues associated with MD.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Honglin Qu et al.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Immunology
Yang Cai et al.
JOURNAL OF NEUROINFLAMMATION
(2016)
Review
Psychiatry
Melissa Furtado et al.
PSYCHIATRY RESEARCH
(2015)
Review
Physiology
Melinda M. Nugent et al.
FRONTIERS IN PHYSIOLOGY
(2015)
Editorial Material
Psychiatry
M. Elizabeth Sublette et al.
PSYCHOSOMATIC MEDICINE
(2012)
Article
Biochemistry & Molecular Biology
Hongzi Liang et al.
MOLECULAR AND CELLULAR BIOLOGY
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Psychology, Biological
RR Hampton et al.
LEARNING AND MOTIVATION
(2005)
