Extracellular lncRNAs secreted and absorbed by cardiomyocytes

Exosomes are membrane-surrounded extracellular vesicles released by almost all cell types, which mediate intercellular communications by delivering bioactive molecules from secretory cells to recipient cells. Long noncoding RNAs (lncRNAs) are a large class of non-(protein)-coding RNAs with lengths exceeding 200 nucleotides that are very active in the development of cardiovascular diseases (CVDs). Increasing evidence suggests that exosomal lncRNAs also play important roles in the progress of CVDs. We focus on the current available studies regarding these extracellular lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, hopefully providing a basis for deeper understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.

Automated summary

Exosomes are membrane-surrounded extracellular vesicles that mediate intercellular communication by delivering bioactive molecules. Long noncoding RNAs (lncRNAs), a class of non-protein-coding RNAs, play important roles in the development of cardiovascular diseases (CVDs). In this article, we review the current studies on exosomal lncRNAs secreted and absorbed by cardiomyocytes and their functional roles in CVDs, aiming to deepen our understanding of the pathological mechanisms of CVDs and their potential for clinical diagnosis and therapy.