4.5 Review

New insight of complement system in the process of vascular calcification

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Review Cardiac & Cardiovascular Systems

The multifaceted impact of complement on atherosclerosis

Mate G. Kiss et al.

Summary: The complement system plays an important role in the pathogenesis of atherosclerosis, with both protective and proatherogenic properties. The role of local complement activation in lesion formation remains unclear.

ATHEROSCLEROSIS (2022)

Article Biochemistry & Molecular Biology

Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury

Ragini Vittal et al.

Summary: This study suggests that overexpression of DAF in fibrosed lungs can restrain complement dysregulation and limit fibrotic injury. Results showed downregulation of DAF and increased ER stress in fibrosed lungs, along with DAF loss induced by exogenous complement. Induction of DAF can reduce fibrotic injury, apoptosis, and ER stress-related transcripts.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2022)

Review Biochemistry & Molecular Biology

The Complement System, Aging, and Aging-Related Diseases

Runzi Zheng et al.

Summary: The complement system is a part of the immune system and plays a role in defense against pathogens and immunomodulation. It is involved in aging, inflammatory processes, metabolism, apoptosis, and aging-related diseases.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Immunology

The Complement System in Metabolic-Associated Kidney Diseases

Ziyu Xu et al.

Summary: This article discusses the issues related to metabolic syndrome and its impact on the kidneys, emphasizing the crucial role of the complement system in metabolic kidney diseases.

FRONTIERS IN IMMUNOLOGY (2022)

Article Environmental Sciences

C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene-sensitization mice

Zhibing Liu et al.

Summary: The study aims to explore renal tubular ferroptosis induced by trichloroethylene sensitization and its mechanism. Through observation of the kidneys of trichloroethylene-sensitized mice and HK-2 cells, it was found that C5b-9 and cytosolic Ca2+ overload may play a key role in renal tubular ferroptosis.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2022)

Article Immunology

Effects of Complement Regulators and Chemokine Receptors in Type 2 Diabetes

B. Aydin Ozgur et al.

Summary: The study suggests that protein levels of CD55 and CD59, as well as polymorphisms in SDF-1 and CXCR-4, may play a predictive role in the progression, complications, and susceptibility of type 2 diabetes mellitus (T2DM). Variations in the expression of these genes and proteins were found to be associated with nephropathy, retinopathy, and cardiovascular diseases related to T2DM.

IMMUNOLOGICAL INVESTIGATIONS (2021)

Article Cell Biology

The HSP GRP94 interacts with macrophage intracellular complement C3 and impacts M2 profile during ER stress

Killian Chaumonnot et al.

Summary: GRP94, an ER stress protein with dual inflammatory functions, is co-secreted with C3 under ER stress conditions in macrophages, contributing to the pro-inflammatory profile observed in stressed cells.

CELL DEATH & DISEASE (2021)

Article Urology & Nephrology

Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis

Idris Boudhabhay et al.

Summary: The study revealed that both the lectin complement pathway and the alternative pathway are activated in rhabdomyolysis-induced acute kidney injury, leading to complement deposition and kidney injury. Experimental evidence showed the direct pathological role of complement in this process.

KIDNEY INTERNATIONAL (2021)

Article Medicine, General & Internal

Avacopan for the Treatment of ANCA-Associated Vasculitis

David R. W. Jayne et al.

Summary: In this study, the C5a receptor inhibitor avacopan was found to be noninferior to prednisone taper in achieving remission at week 26, but superior in achieving sustained remission at week 52 in patients with ANCA-associated vasculitis. All patients received cyclophosphamide or rituximab. The safety and clinical effects of avacopan beyond 52 weeks were not addressed in the trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Immunology

Deposition of the Membrane Attack Complex in Healthy and Diseased Human Kidneys

Jacob J. E. Koopman et al.

Summary: The membrane attack complex C5b-9, a key factor in the complement pathways, is implicated in various kidney diseases by causing cellular injury and inflammation. Understanding the deposition of C5b-9 in the kidney is crucial for predicting treatment outcomes and developing novel therapies targeting its formation.

FRONTIERS IN IMMUNOLOGY (2021)

Article Medicine, General & Internal

Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

Peter Hillmen et al.

Summary: The study demonstrated that Pegcetacoplan was superior to eculizumab in improving hemoglobin and clinical and hematologic outcomes in patients with PNH by providing broad hemolysis control, including control of intravascular and extravascular hemolysis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Cell Biology

FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress

Haeyeon Jang et al.

Summary: The study reveals that FCN3 acts as a tumor suppressor in LUAD by inducing ER stress, leading to apoptosis and cell cycle arrest, thus enhancing the survival of LUAD patients.

CELL DEATH & DISEASE (2021)

Article Biotechnology & Applied Microbiology

Antioxidant and C5a-blocking strategy for hepatic ischemia-reperfusion injury repair

Xiaobing Zhang et al.

Summary: The study developed a nanomaterial with high liver uptake rate to scavenge ROS and block C5a, effectively alleviating clinical symptoms of hepatic IRI, reducing the release of pro-inflammatory cytokines, and inhibiting inflammatory reactions. This synthesized Ceria@Apt has great potential for medical application in hepatic IRI repair and other ischemic-related diseases.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

Review Medical Laboratory Technology

Oxidative stress in vascular calcification

Chu-Ting Hu et al.

Summary: Oxidative stress plays a key role in the onset and progression of vascular calcification, with various factors influencing the production of reactive oxygen species. Excess ROS-induced oxidative stress is a critical mediator promoting vascular calcification, making antioxidants a potential novel treatment option.

CLINICA CHIMICA ACTA (2021)

Article Pharmacology & Pharmacy

Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

Wu Zeng et al.

Summary: With the increase in human lifespan, population aging has become a major global issue. Aging is an irreversible progressive process that affects humans through various factors. Traditional herbal plants have been widely used for anti-aging and modulation of aging-related symptoms due to their safety and polypharmacological potency.

PHARMACOLOGICAL RESEARCH (2021)

Article Oncology

Complement factor B regulates cellular senescence and is associated with poor prognosis in pancreatic cancer

Reiri Shimazaki et al.

Summary: The study identified complement factor B (CFB) as a key secreted protein involved in the progression of PDAC, promoting cellular proliferation and immunological tumor promotion. High stromal CFB expression was associated with unfavorable clinical outcomes in PDAC patients, indicating CFB may be a potential therapeutic target.

CELLULAR ONCOLOGY (2021)

Article Cardiac & Cardiovascular Systems

Complement C5 Protein as a Marker of Subclinical Atherosclerosis

Diego Martínez-López et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Cell Biology

Lipid mass spectrometry imaging and proteomic analysis of severe aortic stenosis

Jihyeon Lim et al.

JOURNAL OF MOLECULAR HISTOLOGY (2020)

Article Multidisciplinary Sciences

Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade

Ying Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, Research & Experimental

Complement C3 deficiency ameliorates aging related changes in the kidney

Xiaoting Wu et al.

LIFE SCIENCES (2020)

Article Biochemistry & Molecular Biology

ApoE attenuates unresolvable inflammation by complex formation with activated C1q

Changjun Yin et al.

NATURE MEDICINE (2019)

Article Cardiac & Cardiovascular Systems

Plasma Complement Protein C3a Level Was Associated with Abdominal Aortic Calcification in Patients on Hemodialysis

Yaqin Wang et al.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2019)

Article Geriatrics & Gerontology

Aging-induced elevation in circulating complement C1q level is associated with arterial stiffness

Natsuki Hasegawa et al.

EXPERIMENTAL GERONTOLOGY (2019)

Article Biochemistry & Molecular Biology

High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells

I-Jung Tsai et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Clinical Neurology

High complement levels in astrocyte-derived exosomes of Alzheimer disease

Edward J. Goetzl et al.

ANNALS OF NEUROLOGY (2018)

Review Cardiac & Cardiovascular Systems

Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness

Andrew L. Durham et al.

CARDIOVASCULAR RESEARCH (2018)

Review Cardiac & Cardiovascular Systems

Cell-Matrix Interactions and Matricrine Signaling in the Pathogenesis of Vascular Calcification

David Ngai et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

Article Endocrinology & Metabolism

Complement C3 Associates With Incidence of Diabetes, but No Evidence of a Causal Relationship

Yan Borne et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2017)

Article Endocrinology & Metabolism

Diabetes Is Associated with Increased Autoreactivity of Mannan-Binding Lectin

Esben Axelgaard et al.

JOURNAL OF DIABETES RESEARCH (2017)

Editorial Material Urology & Nephrology

Complement in Kidney Disease: Core Curriculum 2015

Joshua M. Thurman

AMERICAN JOURNAL OF KIDNEY DISEASES (2015)

Article Cardiac & Cardiovascular Systems

Vascular calcification: Mechanisms of vascular smooth muscle cell calcification

Jane A. Leopold

TRENDS IN CARDIOVASCULAR MEDICINE (2015)

Article Endocrinology & Metabolism

Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation

Kazuhiko Matsuoka et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Medicine, General & Internal

Excessive activation of the alternative complement pathway in autosomal dominant polycystic kidney disease

Z. Su et al.

JOURNAL OF INTERNAL MEDICINE (2014)

Review Cell Biology

N-glycomic biomarkers of biological aging and longevity: A link with inflammaging

Fabio Dall'Olio et al.

AGEING RESEARCH REVIEWS (2013)

Article Endocrinology & Metabolism

Increased Complement Activation in Human Type 1 Diabetes Pancreata

Patrick Rowe et al.

DIABETES CARE (2013)

Article Cell Biology

Activity of mannose-binding lectin in centenarians

Rossella Tomaiuolo et al.

AGING CELL (2012)

Review Medical Laboratory Technology

Complement C3 and cleavage products in cardiometabolic risk

Altan Onat et al.

CLINICA CHIMICA ACTA (2011)

Article Medicine, Research & Experimental

Complement Proteins C3 and C4 Bind to Collagen and Elastin in the Vascular Wall: A Potential Role in Vascular Stiffness and Atherosclerosis

Kelly J. Shields et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2011)

Article Biochemistry & Molecular Biology

Complement C3a and C5a Modulate Osteoclast Formation and Inflammatory Response of Osteoblasts in Synergism With IL-1β

Anita Ignatius et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma

Purushottam Jha et al.

MOLECULAR IMMUNOLOGY (2011)

Article Multidisciplinary Sciences

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

David Weismann et al.

NATURE (2011)

Review Biochemistry & Molecular Biology

Enzymatically Modified Low-Density Lipoprotein Is Recognized by C1q and Activates the Classical Complement Pathway

Gerard J. Arlaud et al.

JOURNAL OF LIPIDS (2011)

Article Biochemical Research Methods

Characterization of the renal cyst fluid proteome in autosomal dominant polycystic kidney disease (ADPKD) patients

Xianyin Lai et al.

PROTEOMICS CLINICAL APPLICATIONS (2008)

Article Physiology

Complement activation by tubular cells is mediated by properdin binding

Hilde Gaarkeuken et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2008)

Article Urology & Nephrology

Calcification of coronary intima and media: Immunohistochemistry, backscatter imaging, and X-ray analysis in renal and nonrenal patients

Marie-Luise Gross et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2007)

Article Cardiac & Cardiovascular Systems

Complement component C5a predicts future cardiovascular events in patients with advanced atherosclerosis

WS Speidl et al.

EUROPEAN HEART JOURNAL (2005)

Article Medicine, General & Internal

C5a delays apoptosis of human neutrophils via an extracellular signal-regulated kinase and Bad-mediated signalling pathway

MC Perianayagam et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2004)

Article Rheumatology

Factors associated with coronary artery calcification in young female patients with SLE

K Manger et al.

ANNALS OF THE RHEUMATIC DISEASES (2003)

Article Cardiac & Cardiovascular Systems

Influence of C3 deficiency on atherosclerosis

C Buono et al.

CIRCULATION (2002)

Article Biochemistry & Molecular Biology

Local synthesis of complement component C3 regulates acute renal transplant rejection

JR Pratt et al.

NATURE MEDICINE (2002)

Article Hematology

Complement components, but not complement inhibitors, are upregulated in atherosclerotic plaques

K Yasojima et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2001)