4.7 Article

A two-step mitochondrial import pathway couples the disulfide relay with matrix complex I biogenesis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

The assembly, regulation and function of the mitochondrial respiratory chain

Irene Vercellino et al.

Summary: The mitochondrial oxidative phosphorylation system is essential for cellular metabolism, driving ATP production through the electron transport chain. Recent studies have provided insights into the organization, assembly, and mechanisms of the respiratory complexes, including the formation of larger assemblies such as respiratory supercomplexes, and their roles in physiology.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Review Biochemistry & Molecular Biology

Mitochondrial matrix proteases: quality control and beyond

Karolina Szczepanowska et al.

Summary: Mitochondria rely on chaperones and proteases for protein homeostasis, with proteases like LON and ClpXP modulating essential functions beyond quality control. Impaired mitochondrial protease function is linked to various pathological conditions, and recent research has identified them as potential targets for anticancer therapies.

FEBS JOURNAL (2022)

Article Multidisciplinary Sciences

Defining mitochondrial protein functions through deep multiomic profiling

Jarred W. Rensvold et al.

Summary: Mitochondria, as the epicentres of eukaryotic metabolism and bioenergetics, are linked to numerous diseases. However, the functions of many mitochondrial proteins are still unclear, and the genetic basis of many mitochondrial disorders remains unresolved. Through mass spectrometry-based multiomics analyses, we have established a comprehensive functional compendium of human mitochondrial proteins, providing a foundation for mechanistic investigations and genetic diagnosis of mitochondrial diseases. Our findings have identified specific proteins associated with mitochondrial function and disorders, and defined a rich cell signature of mitochondrial dysfunction.

NATURE (2022)

Article Biochemical Research Methods

Human mitochondrial protein complexes revealed by large-scale coevolution analysis and deep learning-based structure modeling

Jimin Pei et al.

Summary: Recent advances in deep-learning methods have significantly improved the accuracy of predicting 3D protein structures. This study applied two state-of-the-art deep-learning methods, RoseTTAFold and AlphaFold, to analyze the coevolution of human mitochondrial proteins. The results showed that these methods successfully predicted protein-protein interactions and complex structures, providing insights into the molecular functions of the proteins involved.

BIOINFORMATICS (2022)

Article Biochemistry & Molecular Biology

AIFM1 is a component of the mitochondrial disulfide relay that drives complex I assembly through efficient import of NDUFS5

Silja Lucia Salscheider et al.

Summary: The study shows that AIFM1 and MIA40/CHCHD4 cooperate beyond the import of MIA40/CHCHD4 and form a stable complex in vitro, in different cell lines, and in tissues. AIFM1 serves two overlapping functions, importing MIA40/CHCHD4 and constituting an integral part of the disulfide relay.

EMBO JOURNAL (2022)

Review Biochemistry & Molecular Biology

Apoptosis inducing factor and mitochondrial NADH dehydrogenases: redox-controlled gear boxes to switch between mitochondrial biogenesis and cell death

Johannes M. Herrmann et al.

Summary: Mitochondrial complex I serves as an entry point for NADH into the electron transport chain, while AIFM1 and Nde1 act as NADH dehydrogenases that can promote mitochondrial respiration and induce cell death.

BIOLOGICAL CHEMISTRY (2021)

Review Cell Biology

Quality control of the mitochondrial proteome

Jiyao Song et al.

Summary: Mitochondria contain a diverse array of proteins from two genomes and require synchronized gene expression for proper function. The mitochondrial proteome is highly adaptable and regulated by quality control systems to ensure cellular adaptation and functionality. Defects in mitochondrial protein quality control mechanisms can lead to proteotoxic insults and cell death, highlighting the critical importance of maintaining protein homeostasis in mitochondria.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Cell Biology

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

Marcel Morgenstern et al.

Summary: Researchers have classified and identified human mitochondrial proteins, establishing a high-confidence mitochondrial proteome containing over 1,100 proteins, which account for 7% of cellular proteins and are linked to various diseases.

CELL METABOLISM (2021)

Article Cell Biology

W196 and the β-Hairpin Motif Modulate the Redox Switch of Conformation and the Biomolecular Interaction Network of the Apoptosis-Inducing Factor

Silvia Romero-Tamayo et al.

Summary: The human apoptosis-inducing factor (hAIF) acts as a NAD(H/(+)) redox sensor, with its structural transition modulating its functions in mitochondrial respiratory complex assembly and programmed cell death. The interaction between W196 and the beta-hairpin motif plays a crucial role in stabilizing hAIF and configuring its active site for hydride transfer. Additionally, the beta-hairpin motif defines AIF's interaction surfaces with its physiological partners, enhancing our understanding of its cellular activities and associated pathological mechanisms.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Cell Biology

Mechanisms and regulation of protein synthesis in mitochondria

Eva Kummer et al.

Summary: Mitochondria are cellular organelles that generate chemical energy through oxidative phosphorylation. They have their own genetic information and unique translation machinery, but also heavily rely on nuclear-encoded proteins and engage in inter-compartmental crosstalk with the cell to regulate their proteome and respond to stress. Understanding the mechanisms and regulation of mitochondrial protein synthesis has increased our knowledge of mitochondrial function and its integration with overall cell physiology.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways

Ruairidh Edwards et al.

Summary: The mitochondrial intermembrane space (IMS) is a narrow sub-mitochondrial compartment with diverse protein import mechanisms. IMS proteins do not require energy to cross the outer mitochondrial membrane, unlike import into the matrix or inner membrane. Many IMS proteins are associated with human diseases, highlighting the importance of understanding their normal function and localization in the IMS.

OPEN BIOLOGY (2021)

Article Multidisciplinary Sciences

Mapping protein interactions in the active TOM-TIM23 supercomplex

Ridhima Gomkale et al.

Summary: The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. By using a stalled client protein, the authors purified the translocation supercomplex and gained insights into the TOM-TIM23 interface and the mechanism of protein handover from the TOM to the TIM23 complex.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

Article Multidisciplinary Sciences

Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery

Corvin Walter et al.

Summary: The study shows that DYRK1A phosphorylates TOM70 to promote import of precursor proteins into mitochondria. Inhibition of DYRK1A impairs mitochondrial structure and function, leading to a decrease in metabolite carrier import capacity.

NATURE COMMUNICATIONS (2021)

Article Biology

Protein Import Assay into Mitochondria Isolated from Human Cells

Lena M. Murschall et al.

Summary: Mitochondria are essential organelles containing approximately 1,500 proteins, with only around 1% synthesized inside mitochondria. Various tools and techniques have been developed to analyze the import process, with in vitro reconstituted import systems being important for detailed study. These experiments monitor the import reaction of mitochondria precursors, with the method now adapted to import proteins into crude mitochondria isolated from human tissue culture cells.

BIO-PROTOCOL (2021)

Review Cell Biology

Mitochondria as multifaceted regulators of cell death

Florian J. Bock et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Genetics & Heredity

Pathogenic Bi-allelic Mutations in NDUFAF8 Cause Leigh Syndrome with an Isolated Complex I Deficiency

Charlotte L. Alston et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2020)

Review Biochemistry & Molecular Biology

Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity

Soni Deshwal et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89 (2020)

Article Biochemistry & Molecular Biology

AIF meets the CHCHD4/Mia40-dependent mitochondrial import pathway

Camille Reinhardt et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2020)

Review Biochemistry & Molecular Biology

From TOM to the TIM23 complex - handing over of a precursor

Sylvie Callegari et al.

BIOLOGICAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Protein import by the mitochondrial disulfide relay in higher eukaryotes

Yannik Finger et al.

BIOLOGICAL CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

How to get to the other side of the mitochondrial inner membrane - the protein import motor

Dejana Mokranjac

BIOLOGICAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Chchd2 regulates mitochondrial morphology by modulating the levels of Opa1

Wei Liu et al.

CELL DEATH AND DIFFERENTIATION (2020)

Review Multidisciplinary Sciences

Mitochondrial TCA cycle metabolites control physiology and disease

Inmaculada Martinez-Reyes et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

A salvage pathway maintains highly functional respiratory complex I

Karolina Szczepanowsk et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Proteasomal degradation induced by DPP9-mediated processing competes with mitochondrial protein import

Yannik Finger et al.

EMBO JOURNAL (2020)

Review Pharmacology & Pharmacy

Cysteine residues in mitochondrial intermembrane space proteins: more than just import

Markus Habich et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Review Biochemistry & Molecular Biology

Transport of Proteins into Mitochondria

Katja G. Hansen et al.

PROTEIN JOURNAL (2019)

Article Multidisciplinary Sciences

Mitochondrial protein translocation-associated degradation

Christoph U. Martensson et al.

NATURE (2019)

Article Multidisciplinary Sciences

Role of the membrane potential in mitochondrial protein unfolding and import

Takehiro K. Sato et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

Thomas MacVicar et al.

NATURE (2019)

Review Cell Biology

Mitochondrial proteins: from biogenesis to functional networks

Nikolaus Pfanner et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions

S. R. Burstein et al.

HUMAN MOLECULAR GENETICS (2018)

Article Biochemistry & Molecular Biology

PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria

Shotaro Saita et al.

EMBO JOURNAL (2018)

Review Cell Biology

The multifaceted contributions of mitochondria to cellular metabolism

Jessica B. Spinelli et al.

NATURE CELL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

The mitochondrial oxidoreductase CHCHD4 is present in a semi-oxidized state in vivo

Alican J. Erdogan et al.

REDOX BIOLOGY (2018)

Review Cell Biology

Pathways to balance mitochondrial translation and protein import

Chantal Priesnitz et al.

GENES & DEVELOPMENT (2018)

Review Cell Biology

The TIM23 mitochondrial protein import complex: function and dysfunction

Keren Demishtein-Zohary et al.

CELL AND TISSUE RESEARCH (2017)

Article Biochemistry & Molecular Biology

Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44

Non Miyata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Biochemical Research Methods

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast

Sarah E. Calvo et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

Article Biochemistry & Molecular Biology

Control of mitochondrial biogenesis and function by the ubiquitin - proteasome system

Piotr Bragoszewski et al.

OPEN BIOLOGY (2017)

Article Cell Biology

The Assembly Pathway of Mitochondrial Respiratory Chain Complex I

Sergio Guerrero-Castillo et al.

CELL METABOLISM (2017)

Review Biochemistry & Molecular Biology

Organization and Regulation of Mitochondrial Protein Synthesis

Martin Ott et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Article Biochemistry & Molecular Biology

NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I

Virginie F. Rhein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function

Brendan J. Floyd et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Synchronized mitochondrial and cytosolic translation programs

Mary T. Couvillion et al.

NATURE (2016)

Article Biochemistry & Molecular Biology

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH: Ubiquinone Oxidoreductases (NDH-2)

Mahmoud M. Elguindy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biochemistry & Molecular Biology

Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis

Emilie Hangen et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Lidia Wrobel et al.

NATURE (2015)

Review Cell Biology

Integrating mitochondrial translation into the cellular context

Ricarda Richter-Dennerlein et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Biochemical Research Methods

N-terminome analysis of the human mitochondrial proteome

Alvaro Sebastian Vaca Jacome et al.

PROTEOMICS (2015)

Review Cell Biology

Unlocking the presequence import pathway

Christian Schulz et al.

TRENDS IN CELL BIOLOGY (2015)

Article Cell Biology

Loss of apoptosis-inducing factor critically affects MIA40 function

K. Meyer et al.

CELL DEATH & DISEASE (2015)

Article Biochemistry & Molecular Biology

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

Tessa G. Montague et al.

NUCLEIC ACIDS RESEARCH (2014)

Review Biochemistry & Molecular Biology

Control of protein synthesis in yeast mitochondria: The concept of translational activators

Johannes M. Herrmann et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Biochemical Research Methods

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran et al.

NATURE PROTOCOLS (2013)

Review Biochemistry & Molecular Biology

The N-End Rule Pathway

Takafumi Tasaki et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Article Biochemistry & Molecular Biology

Early complex I assembly defects result in rapid turnover of the ND1 subunit

Olga Zurita Rendon et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Multidisciplinary Sciences

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Amrita M. Nargund et al.

SCIENCE (2012)

Review Biochemistry & Molecular Biology

Structural insight into the mitochondrial protein import system

Toshiya Endo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2011)

Article Biochemistry & Molecular Biology

Regulation of Mitochondrial Protein Import by Cytosolic Kinases

Oliver Schmidt et al.

Article Multidisciplinary Sciences

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

Takuya Shiota et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Molecular recognition and substrate mimicry drive the electron-transfer process between MIA40 and ALR

Lucia Banci et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Assembly Factors of Human Mitochondrial Complex I and Their Defects in Disease

Matthew Mckenzie et al.

IUBMB LIFE (2010)

Article Genetics & Heredity

Defective complex I assembly due to C20orf7 mutations as a new cause of Leigh syndrome

M. Gerards et al.

JOURNAL OF MEDICAL GENETICS (2010)

Review Biochemistry & Molecular Biology

Importing Mitochondrial Proteins: Machineries and Mechanisms

Agnieszka Chacinska et al.

Article Biochemistry & Molecular Biology

Systematic Analysis of the Twin Cx9C Protein Family

Sebastian Longen et al.

JOURNAL OF MOLECULAR BIOLOGY (2009)

Article Cell Biology

Identification of the Signal Directing Tim9 and Tim10 into the Intermembrane Space of Mitochondria

Dusanka Milenkovic et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Biochemistry & Molecular Biology

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria

Lucia Banci et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Genetics & Heredity

Mutation of C20orf7 Disrupts Complex I Assembly and Causes Lethal Neonatal Mitochondrial Disease

Canny Sugiana et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2008)

Article Cell Biology

The disulfide relay system of mitochondria is connected to the respiratory chain

Karl Bihlmaier et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space

S Hofmann et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

The essential mitochondrial protein Erv1 cooperates with Mia40 in biogenesis of intermembrane space proteins

M Rissler et al.

JOURNAL OF MOLECULAR BIOLOGY (2005)

Article Biochemistry & Molecular Biology

Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins

A Chacinska et al.

EMBO JOURNAL (2004)

Review Biochemistry & Molecular Biology

Functions of outer membrane receptors in mitochondrial protein import

T Endo et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2002)

Article Biochemistry & Molecular Biology

Protein unfolding by the mitochondrial membrane potential

SH Huang et al.

NATURE STRUCTURAL BIOLOGY (2002)